JBCS

17:11, Fri Dec 9

Open Access/APCs

Current Issue vol. 28, No. 2, 2017, p. 203-390

 

Basic biology research shows that the haemostatic components and the cancer biology are interlinked in multiple ways. Nonetheless, it is noteworthy that while a group of cancer cells is capable of activating the clotting system, haemostatic factors play a role in tumor progression. In this research a novel 4-S lactam derivative was obtained through microwave assisted methodology as a promising leader for the development of new antitumor drugs. Moreover this original compound was selectively toxic to the HCT-116 cell line with low inhibitory Factor Xa (FXa) effect. Details are presented in the Communication Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity by Nicolás E. Núñez-Navarro, Gerardine F. Segovia, Renato A. Burgos, Carlos F. Lagos, Nataly Fuentes-Ibacache, Mario A. Faúndez and Flavia C. Zacconi on page 203.


Cover Article
J. Braz. Chem. Soc. 2017, 28(2), 203-207

Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity

Nicolás E. Núñez-Navarro; Gerardine F. Segovia; Renato A. Burgos; Carlos F. Lagos; Nataly Fuentes-Ibacache; Mario A. Faúndez; Flavia C. Zacconi

How to cite this article

Basic biology research shows that the haemostatic components and the cancer biology are interlinked in multiple ways. Nonetheless, it is noteworthy that while a group of cancer cells is capable of activating the clotting system, haemostatic factors play a role in tumor progression. In this research a novel 4-S lactam derivative was obtained through microwave assisted methodology as a promising leader for the development of new antitumor drugs. Moreover this original compound was selectively toxic to the HCT-116 cell line with low inhibitory Factor Xa (FXa) effect. Details are presented in the Communication Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity by Nicolás E. Núñez-Navarro, Gerardine F. Segovia, Renato A. Burgos, Carlos F. Lagos, Nataly Fuentes-Ibacache, Mario A. Faúndez and Flavia C. Zacconi on page 203.

http://dx.doi.org/10.21577/0103-5053.20160292

Published online: November 4, 2016

Communication J. Braz. Chem. Soc. 2017, 28(2), 203-207

Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity

Nicolás E. Núñez-Navarro; Gerardine F. Segovia; Renato A. Burgos; Carlos F. Lagos; Nataly Fuentes-Ibacache; Mario A. Faúndez; Flavia C. Zacconi

How to cite this article

 

Novel six-membered lactam derivatives were synthesized using microwave methodology. Cytotoxicity of products on cell lines and FXa activity assays are also reported.

http://dx.doi.org/10.21577/0103-5053.20160292

Published online: November 4, 2016


Articles J. Braz. Chem. Soc. 2017, 28(2), 208-216

Smectite Clay Modified with Quaternary Ammonium as Oil Remover

Carlos A. Lira Junior; Domingos S. A. Silva; Arão P. da Costa Filho; Elizabete F. Lucas; Sirlane A. A. Santana

How to cite this article

 

Smectite clay modified with cetyltrimethylammonium bromide surfactant and its ability to remove oil from aqueous effluents.

http://dx.doi.org/10.5935/0103-5053.20160165

Published online: May 31, 2016

J. Braz. Chem. Soc. 2017, 28(2), 217-224

Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines

Eric F. S. dos Santos; Nathália M. Cury; Tainara A. do Nascimento; Cristiano Raminelli; Gleison A. Casagrande; Claudio M. P. Pereira; Euclésio Simionatto; José A. Yunes; Lucas Pizzuti

How to cite this article

 

3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently synthesized through a cyclocondensation reaction between aminoguanidine hydrochloride and thiophenylchalcones under ultrasonic conditions employing KOH and ethanol in short reaction times and good yields. All compounds produced were evaluated against three leukemia cell lines.

http://dx.doi.org/10.5935/0103-5053.20160166

Published online: May 31, 2016


J. Braz. Chem. Soc. 2017, 28(2), 225-235

Ion Exchange Chromatography and Mass Bias Correction for Accurate and Precise Zn Isotope Ratio Measurements in Environmental Reference Materials by MC-ICP-MS

Daniel F. Araújo; Geraldo R. Boaventura; Jerôme Viers; Daniel S. Mulholland; Dominik Weiss; Débora Araújo; Bárbara Lima; Izabel Ruiz; Wilson Machado; Marly Babinski; Elton Dantas

How to cite this article

 

Zinc isotope ratios were determined in soil, plant, rock and sediment reference materials by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). The procedure encompassed an improved ion exchange chromatography protocol for fast and simple Zn separation, investigations into the instrumental mass bias processes and its correction using different approaches.

http://dx.doi.org/10.5935/0103-5053.20160167

Published online: May 31, 2016

J. Braz. Chem. Soc. 2017, 28(2), 236-241

Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations

Osmar P. Almeida; Sara P. S. Marcial;Florena P. P. Gouveia; Guilherme Carneiro

How to cite this article

 

A new chromatographic method was developed and validated for the determination of benznidazole incorporated within nanoemulsions or nanostructured lipid carriers.

http://dx.doi.org/10.5935/0103-5053.20160168

Published online: May 31, 2016

J. Braz. Chem. Soc. 2017, 28(2), 242-249

Structural Analysis of High-Spin States of S0-S4 at OEC Complex: A Theoretical Approach of Small Models

Eduardo W. Castilho-Almeida; Diego Paschoal; Hélio F. dos Santos; Patrick J. O'Malley; Wagner B. de Almeida

How to cite this article

 

Small model of oxygen evolving complex (OEC) cluster.

http://dx.doi.org/10.5935/0103-5053.20160169

Published online: June 1, 2016


J. Braz. Chem. Soc. 2017, 28(2), 250-256

Determination of Moxidectin in Serum by Liquid Chromatography-Tandem Mass Spectrometry and Its Application in Pharmacokinetic Study in Lambs

Rafaela C. Baptista; Maria A. M. Fernandes; Susana Gilaverte; Sonia C. N. Queiroz; Marcia R. Assalin; Vera L. Ferracini; Alda L. G. Monteiro; Felix G. R. Reyes

How to cite this article

 

Determination of moxidectin in serum by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study in lambs.

http://dx.doi.org/10.5935/0103-5053.20160171

Published online: June 2, 2016

J. Braz. Chem. Soc. 2017, 28(2), 257-265

Development of Molecularly Imprinted Polymers for Solid Phase Extraction of Parabens in Plasma Samples and Analysis by UHPLC-MS/MS

Mariane V. Roldão; Lidervan P. Melo; Luis Felippe C. Miranda; Marcos G. Resende; Maria Eugênia C. Queiroz

How to cite this article

 

Development of molecularly imprinted polymers for solid phase extraction of parabens in plasma samples and analysis by UHPLC-MS/MS.

http://dx.doi.org/10.5935/0103-5053.20160172

Published online: June 3, 2016

J. Braz. Chem. Soc. 2017, 28(2), 266-276

Speciation of Chromium in Water Samples after Dispersive Liquid-Liquid Microextraction, and Detection by Means of High-Resolution Continuum Source Atomic Absorption Spectrometry

Daniele S. Porto; Naomi Akiba; Marcone Augusto L. de Oliveira; Ivanise Gaubeur

How to cite this article

 

Speciation and determination of Cr after liquid-liquid microextraction combined with high-resolution continuum source atomic absorption spectrometry. Different pH value allowed speciation of CrIII and CrVI.

http://dx.doi.org/10.5935/0103-5053.20160173

Published online: June 7, 2016


J. Braz. Chem. Soc. 2017, 28(2), 277-284

Electrochemiluminescence Sensor for the Detection of Tiapride Hydrochloride with Chitosan-Ru(bpy)32+-SiO2NPs/MCNT/Nafion Modified Electrode

Xuemei Fan; Shumin Wang; Zhejian Li; Ping Liu; Yan Yu; Liangliang Chang; Kaibin Li; Xingwang Zheng

How to cite this article

 

The principle diagram of electrochemical luminescence sensor of chitosan-Ru(bpy)32+-SiO2 NPs/MCNT/Nafion for tiapride hydrochloride.

http://dx.doi.org/10.5935/0103-5053.20160174

Published online: June 8, 2016

J. Braz. Chem. Soc. 2017, 28(2), 285-298

New Multicomponent Reaction for the Direct Synthesis of β-Aryl-γ-nitroesters Promoted by Hydrotalcite-Derived Mixed Oxides as Heterogeneous Catalyst

Caroline R. M. D'Oca; Fabricio F. Naciuk; Jéssica C. Silva; Esthéfani P. Guedes; Celso C. Moro; Marcelo G. M. D'Oca; Leonardo S. Santos; Fabiane M. Natchigall; Dennis Russowsky

How to cite this article

 

Multicomponent synthesis of β-aryl-γ-nitroesters promoted by hydrotalcite-derived mixed oxides.

http://dx.doi.org/10.5935/0103-5053.20160175

Published online: June 9, 2016


J. Braz. Chem. Soc. 2017, 28(2), 299-307

Graphene Oxide/Zinc Oxide (GO/ZnO) Nanocomposite as a Superior Photocatalyst for Degradation of Methylene Blue (MB)-Process Modeling by Response Surface Methodology (RSM)

Seyed A. Hosseini; Shabnam Babaei

How to cite this article

 

The scanning electron microscopy (SEM) results revealed the nanostructure of the particles. Under optimum conditions the photocatalytic removal of methylene blue (MB) was 99% by experimental testing.

http://dx.doi.org/10.5935/0103-5053.20160176

Published online: June 9, 2016

J. Braz. Chem. Soc. 2017, 28(2), 308-318

Proximate Composition, Mineral Contents and Fatty Acid Composition of the Different Parts and Dried Peels of Tropical Fruits Cultivated in Brazil

Damila R. Morais; Eliza M. Rotta; Sheisa C. Sargi; Elton G. Bonafe; Rúbia M. Suzuki; Nilson E. Souza; Makoto Matsushita; Jesuí V. Visentainer

How to cite this article

 

Data food composition knowledge is very important. Avocado, pineapple, banana, papaya, passion fruit, watermelon and melon different parts (pulp, peel and seed) cultivated in Brazil have nutrients.

http://dx.doi.org/10.5935/0103-5053.20160178

Published online: June 10, 2016

J. Braz. Chem. Soc. 2017, 28(2), 319-327

Strontium and Nickel Heterogeneous Catalysts for Biodiesel Production from Macaw Oil

Wiury C. de Abreu; Carla V. R. de Moura; Jean C. S. Costa; Edmilson M. de Moura

How to cite this article

 

Strontium and nickel oxides have shown effectiveness for production of biodiesel of macaw oil. The catalyst can be used in many reaction cycles.

http://dx.doi.org/10.5935/0103-5053.20160181

Published online: June 13, 2016

J. Braz. Chem. Soc. 2017, 28(2), 328-335

PhotoMetrix: An Application for Univariate Calibration and Principal Components Analysis Using Colorimetry on Mobile Devices

Gilson A. Helfer; Vinícius S. Magnus; Fernanda C. Böck; Aline Teichmann; Marco F. Ferrão; Adilson B. da Costa

How to cite this article

 

Schematic representation of PhotoMetrix, which employs techniques for univariate analysis and multivariate exploratory analysis.

http://dx.doi.org/10.5935/0103-5053.20160182

Published online: June 13, 2016

J. Braz. Chem. Soc. 2017, 28(2), 336-347

Acidity and Characterization of 12-Tungstophosphoric Acid Supported on Silica-Alumina

Flávia C. G. de Mattos; Eduardo N. C. B. de Carvalho; Elon F. de Freitas; Mateus F. Paiva; Grace F. Ghesti; Julio L. de Macedo; Sílvia C. L. Dias; José A. Dias

How to cite this article

 

12-Tungstophosphoric acid supported on silica-alumina is a stable catalyst with interaction occurring on isolated and aluminic pseudo-bridging silanols. The most active catalyst for acetic acid and ethanol esterification was 30 wt.% H3PW/SiO2-Al2O3, which showed 79 ± 3% yield and 100% selectivity for ethyl acetate after 2 h reaction time.

http://dx.doi.org/10.5935/0103-5053.20160183

Published online: June 14, 2016


J. Braz. Chem. Soc. 2017, 28(2), 348-359

Physicochemical Properties and Field Evaluation of Monolithic Wax Formulations for the Controlled Release of a Forest Pest Pheromone

Mariel P. Slodowicz; Esteban Ceriani-Nakamurakare; Cecilia Carmarán; Paola A. González-Audino

How to cite this article

 

Development of monolithic dispensers for the controlled release of the pheromone components of a forest pest and study of its physicochemical properties.

http://dx.doi.org/10.5935/0103-5053.20160184

Published online: June 14, 2016


J. Braz. Chem. Soc. 2017, 28(2), 360-366

Analysis of Xanthine Oxidase Inhibitors from Puerariae flos Using Centrifugal Ultrafiltration Coupled with HPLC-MS

Liangliang Liu; Aiping Xiao; Lei Ma; Defang Li

How to cite this article

 

Four compounds were successfully screened and identified as xanthine oxidase inhibitors from Puerariae flos extract with centrifugal ultrafiltration coupled with high performance liquid chromatography-mass spectrometry (CU-LC-MS).

http://dx.doi.org/10.5935/0103-5053.20160185

Published online: June 21, 2016

J. Braz. Chem. Soc. 2017, 28(2), 367-375

A New Furanoheliangolide Sesquiterpene Lactone from Calea pinnatifida (R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal Activities

Tamires Cardoso Lima; Rafaela de Jesus Souza; Milene Hoehr de Moraes; Mário Steindel; Maique Weber Biavatti

How to cite this article

 

Isolation and characterization of a new sesquiterpene lactone of the furanoheliangolide type named 11,13-dihydroxy-calaxin, in addition to seven known compounds from Calea pinnatifida leaves.

http://dx.doi.org/10.5935/0103-5053.20160186

Published online: June 21, 2016


J. Braz. Chem. Soc. 2017, 28(2), 376-384

Multielement Determination of Macro and Micro Contents in Medicinal Plants and Phytomedicines from Brazil by ICP OES

Aníbal de F. Santos Júnior; Rafael A. Matos; Eberson M. J. Andrade; Walter N. L. dos Santos; Hemerson I. F. Magalhães; Fernanda do N. Costa; Maria das Graças A. Korn

How to cite this article

 

The metal content of nine medicinal plants and phytomedicines from Brazil was evaluated by inductively coupled plasma optical emission spectrometry (ICP OES).

http://dx.doi.org/10.5935/0103-5053.20160187

Published online: June 21, 2016

J. Braz. Chem. Soc. 2017, 28(2), 385-390

Non-Invasive Detection of Adulterated Olive Oil in Full Bottles Using Time-Domain NMR Relaxometry

Poliana M. Santos; Flávio Vinicius C. Kock; Maiara S. Santos; Carlos Manuel S. Lobo; André S. Carvalho; Luiz Alberto Colnago

How to cite this article

 

A new procedure to detect the authenticity of commercial olive oils, commonly adulterated with polyunsaturated oils, employing low-field nuclear magnetic resonance (LF-NMR) directly in the sealed bottles is proposed.

http://dx.doi.org/10.5935/0103-5053.20160188

Published online: June 21, 2016

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

Tel/Fax: +55.19.3521.3151
Free access

GN1