A survey of JBCS statistics for last year shows
that most of our progress indicators remained stable:
the number of submitted manuscript (774), the
number of published papers (300), the percentage of submissions
coming from foreign authors (60% of the total) - even though the number of published
papers followed an opposite tendency (70% from Brazilian authors) - and
citation indexes such as the ISI impact factor (above 1.3), among others. The
time between submission and online publication, onde the other hand ...
Molecular
Docking and Molecular Dynamic Studies of Semi-Synthetic Piperidine Alkaloids
as Acetylcholinesterase Inhibitors
Amanda
Danuello, Nelilma C. Romeiro, Guilherme M. Giesel, Marcos Pivatto, Claudio
Viegas Jr., Hugo Verli, Eliezer J. Barreiro, Carlos A. M. Fraga, Newton
G. Castro and Vanderlan S. Bolzani
This cover figure was inspired
in the rare alkaloids (-)-spectaline and (-)-cassine accumulated in
the beautiful yellow flowers of Senna spectabilis. This creative art
simulates the best docking pose obtained for (-)-O-acetyl-cassine in
active site of acetylcholinesterase. Details are discussed in the Article
Molecular Docking and Molecular Dynamic Studies of Semi-Synthetic Piperidine
Alkaloids as Acetylcholinesterase Inhibitors by Danuello et al.
on page 163.
>>
Editorial(220
KB) New year,
new challenges!
Jaísa Fernandes Soares and Watson Loh
J.
Braz. Chem. Soc.2012, 23, 1.
COMMUNICATIONS
Asymmetric
Organocatalytic Synthesis of β-Hydroxyynones
with a Quaternary Carbon Center under Aqueous Conditions
Guowei Kang, Jun Jiang, Hongxin Liu and Huayue Wu
J.
Braz. Chem. Soc.2012, 23, 5.
The
chiral thiourea catalyzed direct aldol reaction of unmodified methyl
ynones under aqueous conditions is described. This procedure afforded
β-hydroxyynones bearing a quaternary carbon center with moderate
to good yields and enantioselectivities
Biomedical
Applications of Nanobiosensors: the State-of-the-Art
Mahendra Rai, Aniket Gade, Swapnil Gaikwad, Priscyla D. Marcato and
Nelson Durán
J.
Braz. Chem. Soc.2012, 23, 14.
Optical
nanobiosensors with nanometric-sized dimensions opened new researches
for intra-cellular monitoring leading to develop sensitive robust and
reproducible nanobiosensors. The sensors are equipped with immobilized
bio-receptor probes, e.g. antibodies, enzyme substrate etc and
these probes will revolutionize the future of disease diagnosis
Synthesis,
Characterization and Photophysical Properties of ESIPT Reactive Triazine
Derivatives
Marcelo D. Kuplich, Fábio S. Grasel, Leandra F. Campo, Fabiano
S. Rodembusch and Valter Stefani
J.
Braz. Chem. Soc.2012, 23, 25.
We
present four reactive ESIPT fluorescent 1,3,5-triazine derivatives from
nucleophilic aromatic substitution of cyanuric chloride. The dyes are
fluorescent by an intramolecular proton transfer mechanism in the blue-orange
region with a large Stokes shift. The incorporation of the dyes into
cellulose fibers could be done successfully
Pt
L2,3 - Edge X-ray Absorption Spectroscopy
Investigation of Zerovalent [Pt(PPh3)2(η2.L)]
{L = C2H4,
C60 and C2(CN)4}
Compounds
Gilson H. M. Dias, Nazareth F. da Fonseca and Marcelo H. Herbst
J.
Braz. Chem. Soc.2012, 23, 32.
The
dπ-orbital energy of three [Pt(PPh3)2(η2.L)]
compounds {L = C2H4,
C60 and C2(CN)4},
quantitatively determined by Pt L2,3
X-ray absorption spectroscopy (XAS), follows the order [Pt(PPh3)2((η2.C2H4)]
< [Pt(PPh3)2((η2.C60)])
< [Pt(PPh3)2{(η2.C2(CN)4}],
in line with the π-acidity of the olefin ligands
Tributyltin
in Crustacean Tissues: Analytical Performance and Validation of Method
Joyce Cristale, Dayana M. dos Santos, Bruno S. Sant’Anna, Daniela C.
Sandron, Sara Cardoso, Alexander Turra and Mary Rosa R. de Marchi
J.
Braz. Chem. Soc.2012, 23, 39.
Gas
chromatography with pulsed flame photometric detector (GCPFPD) has proved
to be an advantageous technique for tributyltin (TBT) quantification
in crustacean tissues when performed after extraction with an apolar
solvent (toluene) followed by Grignard derivatization
Layered
Metal Laurates as Active Catalysts in the Methyl/Ethyl Esterification
Reactions of Lauric Acid
Fábio da Silva Lisboa, José Eduardo F. da Costa Gardolinski,Claudiney
S. Cordeiro and Fernando Wypych
J.
Braz. Chem. Soc.2012, 23, 46.
The
work describes the catalytic activity of layered laurates in the methyl
(ethyl) esterification reactions of lauric acid, for which conversions
between 75 and 90% were observed. The catalysts were reused in three
consecutive reaction cycles and some of them preserved the structure
and retained the catalytic activity close to those observed in the first
cycle
Evaluation
of Solid-Phase Microextraction using a Polythiophene Film and Liquid
Chromatography with Spectrophotometric Detection for the Determination
of
Antidepressants in Plasma Samples
Juciene A. Caris, Andréa R. Chaves and Maria Eugênia C.
Queiroz
J.
Braz. Chem. Soc.2012, 23, 57.
Polythiophene
films were electropolymerized on the surface of metal (stainless steel)
wires for the development of solid-phase microextraction (SPME). These
polymeric films were evaluated as SPME phases for the liquid chromatography
(LC) analysis of antidepressants in plasma samples for toxicological
analysis purpose
Electrospray
Ionization Tandem Mass Spectrometry of the Two Main Antimalarial Drugs:
Artemether and Lumefantrine
Vanessa G. dos Santos, Ricardo J. Alves, Marcos N. Eberlin, Gerson A.
Pianetti and Isabela C. César
J.
Braz. Chem. Soc.2012, 23, 65.
ESI(+)-MS/MS
spectra of protonated lumefantrine (m/z 528), showing rich dissociation
chemistry. Water loss is the most favored initial dissociation forming
the major fragment ion of m/z 510. This elimination is likely
favored due to the formation of a highly stable, fully delocalized,
resonance stabilized benzyl-like cation, which may rearranges to a tropylium-like
ion
In
Situ Solvent Formation Microextraction based on Ionic Liquids
and 1-(2-Hydroxynaphtalene-1-yl)ethane Oxime for Determination of
Zinc
Mehdi Hosseini, Nasser Dalali, Saeid Mohammad Nejad and Rostam Jamali
J.
Braz. Chem. Soc.2012, 23, 78.
Schematic
diagram for preconcentration and determination of zinc by in situ
solvent formation microextraction based on use of ionic liquid (IL)
) as an extractant solvent, sodium hexafluoro-phosphate (NaPF6)
as an ion-pairing agent, 1-(2-hydroxynaphtalene-1-yl) ethane oxime as
complexing agent and detection by flame atomic absorption spectrometry
HPLC
Determination of Histamine, Tyramine and Amino Acids in Shrimp By-Products
Carolina
Bueno-Solano, Jaime López-Cervantes, Dalia I. Sánchez-Machado
and Olga N. Campas-Baypoli
J.
Braz. Chem. Soc.2012, 23, 96.
In
seafood products is possible the conversion of free amino acid to biogenic
amines by microbial decarboxylation, therefore, the proposed HPLC method
here may be useful for evaluation of the sanitary quality of various
shrimp by-products
Direct
Electrochemical Analysis of Dexamethasone Endocrine Disruptor in Raw
Natural Waters
Thiago M. B. F. Oliveira, Francisco W. P. Ribeiro, Jefferson M. do Nascimento,
Janete E. S. Soares, Valder N. Freire, Helena Becker, Pedro de Lima-Neto
and Adriana N. Correia
J.
Braz. Chem. Soc.2012, 23, 110.
Square-wave
voltammograms and the corresponding analytical curve for various concentrations
of DMZ in raw natural waters on the HMDE under optimum conditions
Morphology,
Microstructure and Electrocatalytic Properties of Activated Copper
Surfaces
Juan C. M. Gamboa, Denise F. S. Petri, Tânia M. Benedetti, Vinicius
R. Gonçales and Mauro Bertotti
J.
Braz. Chem. Soc.2012, 23, 120.
The
electrochemical reduction of nitrate and nitrite is facilitated at copper
cathodes after activation of the surface in acidic medium. To understand
in more details the morphologic change of the surface during the activation
process and its correlation with electrochemical properties, images
of the copper surface were obtained by scanning electron microscopy
(SEM) and atomic force microscopy (AFM)
Total
Synthesis and Allelopathic Activity of Cytosporones A-C
Charles E. M. Zamberlam, Alisson Meza, Carla Braga Leite, Maria Rita
Marques, Dênis P. de Lima and Adilson Beatriz
J.
Braz. Chem. Soc.2012, 23, 124.
The
preparation of cytosporones A-C from the same starting material through
a short synthetic route, with good yields, is reported. All compounds
were tested for allelopathic activity on lettuce seeds. Cytosporone
A and its methylated precursor showed remarkable allelopathic activity,
inhibiting seed germination and seedling growth
Determination
of Polychlorinated Biphenyls in Seawater using Headspace Solid- Phase
Microextraction Coupled with Gas Chromatography-Mass Spectrometry
with the Aid of Experimental Design
Polychlorinated
biphenyls were highly sensitively determined in seawater containing
large amounts of humic substances by combining KMnO4
treatment and headspace solid-phase microextraction coupled with gas
chromatography-mass spectrometry with the aid of experimental design
A
Method for Determination of Ammonia in Air using Oxalic Acid-Impregnated
Cellulose Filters and Fluorimetric Detection
Erika P. Felix and Arnaldo A. Cardoso
J.
Braz. Chem. Soc.2012, 23, 142.
An easy method of application was developed
for the determination of ammonia in ambient air. The samples are collected
using cellulose filters impregnated with oxalic acid, followed of
fluorimetric detection. The method is reliable for measuring low concentrations
of ammonia and where there are rapid fluctuations in their concentrations
Ultra-Performance
Liquid Chromatographic Method for Measurement of Voriconazole in Human
Plasma and Oral Fluid
Paula Boeira, Marina V. Antunes, Huander F. Andreolla, Alessandro C.
Pasqualotto and Rafael Linden
J.
Braz. Chem. Soc.2012, 23, 148.
A
new and extensively validated ultra-performance liquid chromatographic
method for voriconazole measurement in plasma and oral fluid is presented.
Run time was 4 min, with mobile phase comsuption of 2.2 mL per
analysis. Panel A shows a chromatogram of a plasma sample and panel
B shows the chromatogram of an oral fluid sample, both from the same
patient
Molecular
Docking and Molecular Dynamic Studies of Semi-Synthetic Piperidine
Alkaloids as Acetylcholinesterase Inhibitors
Amanda Danuello, Nelilma C. Romeiro, Guilherme M. Giesel, Marcos Pivatto,
Claudio Viegas Jr., Hugo Verli, Eliezer J. Barreiro, Carlos A. M. Fraga,
Newton G. Castro and Vanderlan S. Bolzani
J.
Braz. Chem. Soc.2012, 23, 163. cover
article
Molecular
modeling studies were carried out aiming to elucidate the molecular
basis of the differential acetylcholinesterase inhibition profiles of
the semi-synthetic derivatives (–)-3-O-acetyl-cassine hydrochloride
(9) and (–)-3-O-acetyl-spectaline hydrochloride (10)
Metal
Chloride Hydrates as Lewis Acid Catalysts in Multicomponent Synthesis
of 2,4,5-Triarylimidazoles or 2,4,5-Triaryloxazoles
Marcelo V. Marques, Marcelo M. Ruthner, Luiz A. M. Fontoura and Dennis
Russowsky
J.
Braz. Chem. Soc.2012, 23, 171.
A
series of metal halide hydrates was proved to be efficient Lewis acid
catalysts promoting the multicomponent Radziszewski reaction for the
triarylimidazole synthesis in alcoholic media. In absence of aldehyde,
triaryloxazoles were obtained in good yields
Effects
of the Essential Oil from Fruits of Schinus terebinthifolius
Raddi (Anacardiaceae) on Reproductive Functions in Male Rats
Cristiano R. G. Affonso, Rozeverter M. Fernandes, Jamylla M. G. de Oliveira,
Maria do Carmo de Carvalho e Martins, Sidney G. de Lima, Gustavo R.
de Sousa Júnior, Maria Zenaide de Lima C. Moreno Fernandes and
Surama F. Zanini
J.
Braz. Chem. Soc.2012, 23, 180.
Essential
oils extracted from fruits of Schinus terebinthifolius Raddi
were analyzed by GC and GC-MS, and evaluated for their reproductive
toxicity on male rats. The results showed there are no toxic effects
on male reproduction after treatment with essential oil at the tested
doses
