JBCS

6:14, Fri Oct 31

ADVERTISEMENTS Info

Banner Goes Vidro

Current Issue vol. 25, No. 10, 2014, p. 1755-1926

 

The beginning: global responsibility in healthcare - with a focus on tropical disease

What are "Neglected and Rare Diseases"? And why should one care about them, if they are "rare," or insufficiently problematic to warrant only "neglect" by the medical community?
There are two separate meanings for the phrase "rare and neglected." One refers to diseases that occur infrequently in all populations globally; a second to diseases that occur infrequently in Europe, the United States and other countries with highly developed systems of healthcare.
The former may cause great distress to small numbers of patients, but that small number is seen by health-care systems as simply being too limited in harm done to justify the cost of developing effective drugs, vaccines, or other countermeasures. One may dislike the reasoning, but one can understand the economic argument.

(Read more at Editorial)

Special Issue Neglected and Rare Diseases



Editorial J. Braz. Chem. Soc. 2014, 25(10), 1755

The beginning: global responsibility in healthcare - with a focus on tropical disease

George M. Whitesides

How to cite this article

 

http://dx.doi.org/10.5935/0103-5053.20140236

Reviews J. Braz. Chem. Soc. 2014, 25(10), 1759-1769

NS3 and NS5 Proteins: Important Targets for Anti-Dengue Drug Design

André S. de Oliveira; Milene L. da Silva; Ana Flávia C. S. Oliveira; Cynthia C. da Silva; Róbson R. Teixeira; Sérgio O. De Paula

How to cite this article

 

Dengue virus enzymes are important targets for antiviral drug design.

http://dx.doi.org/10.5935/0103-5053.20140057

Published online: March 21, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1770-1779

Clinical Applications and Methemoglobinemia Induced by Dapsone

Fábio R. Oliveira; Mariely C. Pessoa; Rosyana F. V. Albuquerque; Taysa R. Schalcher; Marta C. Monteiro

How to cite this article

 

This review summarizes the chemical structure of dapsone, a drug used mainly in the treatment of leprosy and dermatitis, and its metabolism leads to the formation of toxic metabolites that cause adverse reactions, such as methemoglobinemia, which occurs because of the inability of methemoglobin to bind oxygen, causing a state of functional anemia.

http://dx.doi.org/10.5935/0103-5053.20140168

Published online: July 22, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1780-1798

Anti-Trypanosoma cruzi Compounds: Our Contribution for the Evaluation and Insights on the Mode of Action of Naphthoquinones and Derivatives

Eufrânio N. da Silva Júnior; Guilherme A. M. Jardim; Rubem F. S. Menna-Barreto; Solange L. de Castro

How to cite this article

 

The present review describes the synthesis of naphthoquinoidal compounds and their derivatives, their activities and mechanisms of action against Trypanosoma cruzi, the causative agent of Chagas disease.

http://dx.doi.org/10.5935/0103-5053.20140180

Published online: August 1, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1799-1809

Control of Neglected Disease Insect Vectors: Future Prospects for the Use of Tools Based on Behavior Manipulation-Interference

Marcelo G. Lorenzo; Diogo M. Vidal; Paulo H. G. Zarbin

How to cite this article

 

The present review describes avenues recently explored for the search of behavior modifying compounds by means of high throughput methodologies. Specifically, examples of how such methodologies mediate the search for new repellents and attractants are described.

http://dx.doi.org/10.5935/0103-5053.20140202

Published online: August 29, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1810-1823

Leishmaniasis and Chagas Disease Chemotherapy: a Critical Review

Izaltina Silva-Jardim; Otavio H. Thiemann; Fernanda F. Anibal

How to cite this article

 

The main form of treatment for leishmaniasis and Chagas disease is still chemotherapy. There is no effective vaccine available and the search for new drugs is a priority. This review outlines the current understanding of different drugs against leishmaniasis and Chagas disease and the search for new drugs.

http://dx.doi.org/10.5935/0103-5053.20140229

Published online: September 30, 2014
Articles J. Braz. Chem. Soc. 2014, 25(10), 1824-1831

Development and Validation of a Method for Simultaneous Determination of Bioactive Compounds of Tanacetum parthenium (L.) Schultz-Bip

Mirela F. Rabito; Mariana B. Almeida; Amanda L. Moreira; Amadeu H. Iglesias; Fernando de Paula; Bruna P. da Silva; Diógenes A. Cortez; Suzana L. Nixdorf; Izabel C. P. Ferreira

How to cite this article

 

This study aimed to develop and validate a liquid cromatographic method for simultaneous determination of two sesquiterpene lactones from Tanacetum parthenium. A potencial tool for quality control of this medicinal plant with in vitro and in vivo antileishmaniasis activities.

http://dx.doi.org/10.5935/0103-5053.20140089

Published online: April 25, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1832-1838

Leishmanicidal Galloylquinic Acids are Noncompetitive Inhibitors of Arginase

Lorena R. F. de Sousa; Suelem D. Ramalho; João B. Fernandes; Maria Fátima das G. F. da Silva; Mônica R. da C. Iemma; Caroindes J. Corrêa; Dulce H. F. de Souza; Maria I. S. Lima; Paulo C. Vieira

How to cite this article

 

Leishmanicidal galloylquinic acids from B. coccolobifolia showed as novel noncompetitive and mixed inhibitors of arginase from L. amazonensis.

http://dx.doi.org/10.5935/0103-5053.20140115

Published online: May 23, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1839-1847

Leishmanicidal Activity of Brosimum glaziovii (Moraceae) and Chemical Composition of the Bioactive Fractions by Using High-Resolution Gas Chromatography and GC-MS

Aline Coqueiro; Luis O. Regasini; Gabriel M. Leme; Luciana Polese; Camila T. Nogueira; Mayara L. Del Cistia; Marcia A. S. Graminha; Vanderlan da S. Bolzani

How to cite this article

 

Chemical composition of the hexane fractions from the leaves and branches of B. glaziovii that exhibited activity in the leishmanicidal tests as evaluated by high-resolution gas chromatography (HRGC) and GC- MS.

http://dx.doi.org/10.5935/0103-5053.20140138

Published online: June 10, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1848-1856

Cobalt(III) Complexes with Thiosemicarbazones as Potential anti-Mycobacterium tuberculosis Agents

Carolina G. Oliveira; Pedro Ivo da S. Maia; Marcelo Miyata; Fernando R. Pavan; Clarice Q. F. Leite; Eduardo Tonon de Almeida; Victor M. Deflon

How to cite this article

 

CoIII complexes with a family of thiosemicarbazones were evaluated for their anti-Mycobacterium tuberculosis effect. Complex 5 exhibited good activity with high selectivity index.

http://dx.doi.org/10.5935/0103-5053.20140149

Published online: June 25, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1857-1863

Potential Diagnostic of Branched-Chain Ketoaciduria by HPLC-DAD

Maíra Magalhães Trintinalia; Atecla Nunciata Lopes Alves; Liliam Fernandes; Etelvino Jose Henriques Bechara; Nilson Antonio Assunção

How to cite this article

 

HPLC profile of three amino acids representative of the biochemical alterations found in maple syrup rinue disease, a metabolic disorder.

http://dx.doi.org/10.5935/0103-5053.20140156

Published online: July 1, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1864-1871

ThermoFMN - A Thermofluor Assay Developed for Ligand-Screening as an Alternative Strategy for Drug Discovery

Ricardo A. P. Pádua; Giovani P. Tomaleri; Renata A. G. Reis; Juliana S. David; Valeria C. Silva; Matheus P. Pinheiro; Maria Cristina Nonato

How to cite this article

 

Monitoring of flavin mononucleotide fluorescence when exposed to solvent upon protein unfolding was used to determine flavoprotein melting temperature (Tm). Interaction of ligands to flavoproteins induces a shift in Tm and this phenomenon can be used on the screening of compounds as a tool for hit identification during the process of drug development.

http://dx.doi.org/10.5935/0103-5053.20140157

Published online: July 1, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1872-1884

Synthesis and in vitro Evaluation of Novel Galactosyl-triazolo-benzenesulfonamides Against Trypanosoma cruzi

Getúlio G. Junqueira; Marcelo R. Carvalho; Peterson de Andrade; Carla D. Lopes; Zumira A. Carneiro; Renata Sesti-Costa; João S. Silva; Ivone Carvalho

How to cite this article

 

Synthesis of galactose-containing triazol-arylsulfonamides and evaluation of Trypanosoma cruzi trans-sialidase inhibition, antitrypanosomal and cytotoxicity activities.

http://dx.doi.org/10.5935/0103-5053.20140158

Published online: July 1, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1885-1899

The Semisynthetic Landscape of Aphidicolin: Inspiration Towards Leishmanicidal Compounds

Gabriela B. Santos; Marília O. Almeida; Iara A. Cardoso; Viviane Manfrim; Fernanda O. Chagas; Juliano S. Toledo; Camila C. Pinzan; Alexandre Suman de Araujo; Angela K. Cruz; Monica T. Pupo; Flavio S. Emery

How to cite this article

 

Preliminary evaluation demonstrated high leishmanicidal activity for aphidicolin and a new oxime derivative with selectivity for the L. braziliensis species.

http://dx.doi.org/10.5935/0103-5053.20140162

Published online: July 11, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1900-1906

Antimalarial Activity of Piperidine Alkaloids from Senna spectabilis and Semisynthetic Derivatives

Marcos Pivatto; Luciene R. Baccini; Abhinay Sharma; Myna Nakabashi; Amanda Danuello; Claudio Viegas Júnior; Celia R. S. Garcia; Vanderlan S. Bolzani

How to cite this article

 

Piperidine alkaloids (-)-cassine and (-)-spectaline isolated from the flowers of Senna spectabilids and semisynthetic derivatives (-)-3-O-acetylcassine and (-)-3-O-acetylspectaline were assessed for their antimalarial inhibitory activity by means of flow cytometry screening assay.

http://dx.doi.org/10.5935/0103-5053.20140195

Published online: August 19, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1907-1913

Application of the Negishi Reaction in the Synthesis of Thiophene-Based Lignans Analogues with Leishmanicidal Effects

Mônica F. Z. J. Amaral; Daniel R. Callejon; Thalita B. Riul; Marcelo D. Baruffi; Fabiano T. Toledo; Norberto P. Lopes; Giuliano C. Clososki

How to cite this article

 

Thiophene derivatives obtained by Negishi reaction induced cell death on Leishmania braziliensis without inducing toxicity on macrophage.

http://dx.doi.org/10.5935/0103-5053.20140196

Published online: August 22, 2014

J. Braz. Chem. Soc. 2014, 25(10), 1914-1917

Inborn Errors of Metabolism, an Important Group of Orphan Neglected Diseases: Investigation of 8,000 Patients in Rio de Janeiro, Brazil

Fernanda B. Scalco; Maria Lúcia C. Oliveira; Ruth E. Simoni; Francisco R. Aquino Neto

How to cite this article

 

The survey presents the results obtained after diagnostic investigation of inborn errors of metabolism (IEM) in 8,000 patients from the state of Rio de Janeiro by qualitative and quantitative methods and the distribution of the diagnosed cases.

http://dx.doi.org/10.5935/0103-5053.20140203

Published online: August 29, 2014
J. Braz. Chem. Soc. 2014, 25(10), 1918-1926

Bioanalytical Studies of Porphyric Disorders Using HPLC with Fluorescence Detection

Michele G. S. C. Cypriani; Atecla N. L. Alves; Etelvino J. H. Bechara; Nilson A. Assunção

How to cite this article

 

High-performance liquid chromatography (HPLC)/fluorescence detection of porphyrins in a standard mixture of six porphyrinogens (black trace) and in the urine of a symptomatic carrier of acute intermittent porphyria (or porphyria cutanea tarda) (red trace). The excitation and emission wavelengths used were 400 and 620 nm, respectively.

http://dx.doi.org/10.5935/0103-5053.20140230

Published online: September 30, 2014

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

Tel/Fax: +55.19.3521.3151
Free access

GN1