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Articles J. Braz. Chem. Soc. 2018

Synthesis of New 1,2,3-Triazolo-naphthalimide/phthalimide Conjugates via 'Click' Reaction: DNA Intercalation and Cytotoxic Studies

Nagula Shankaraiah; Niggula P. Kumar; Ramya Tokala; Bulusu S. Gayatri; Venu Talla; Leonardo S. Santos

1,2,3-Triazolo-naphthalimide/phthalimide conjugates have been synthesized directly from alkyl/benzyl bromides, sodium azide and alkynes by 1,3-dipolar cycloaddition catalyzed by bis[(tetrabutylammonium)di-µ-iodo-diiododicuprate(I)]. The title compounds were evaluated for their in vitro cytotoxic potential and DNA interaction.

http://dx.doi.org/10.21577/0103-5053.20180111

Published online: June 11, 2018.

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
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