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18:03, Fri Jun 14

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Current Issue vol. 35, No. 7, 2024

 

The opioid crisis has led to a need for analytical methods to identify and quantify these drugs. Even with the global discussion, Brazil's data on fentanyl consumption is lacking. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for fentanyl and analogues was developed and validated. The method proved to be useful for routine analysis in forensic toxicology laboratories. Details are presented in the Article Development and Validation of a Method to Analyze Fentanyl and its Analogues in Postmortem Blood Samples by LC-MS/MS by Tas B. Rodrigues, Mrcio H. Matsubara, Elvis M. Aquino, Victor A. P. Gianvecchio, Damila R. Morais and Jose Luiz Costa on e-20240008.


Cover Article
J. Braz. Chem. Soc. 2024, 35(7), e-20240008, 1-8

Development and Validation of a Method to Analyze Fentanyl and Its Analogues in Postmortem Blood Samples by LC-MS/MS

Tas B. Rodrigues ; Mrcio H. Matsubara; Elvis M. Aquino; Victor A. P. Gianvecchio; Damila R. Morais; Jose Luiz Costa

How to cite this article

The opioid crisis has led to a need for analytical methods to identify and quantify these drugs. Even with the global discussion, Brazil's data on fentanyl consumption is lacking. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for fentanyl and analogues was developed and validated. The method proved to be useful for routine analysis in forensic toxicology laboratories. Details are presented in the Article Development and Validation of a Method to Analyze Fentanyl and its Analogues in Postmortem Blood Samples by LC-MS/MS by Tas B. Rodrigues, Mrcio H. Matsubara, Elvis M. Aquino, Victor A. P. Gianvecchio, Damila R. Morais and Jose Luiz Costa on e-20240008.

https://dx.doi.org/10.21577/0103-5053.20240008

Published online: January  19, 2024
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Review J. Braz. Chem. Soc. 2024, 35(7), e-20240021, 1-41

Prenylated and Geranylated Derivatives of Non-Oxidized Monomeric Acylphloroglucinols of Natural Origin: Occurrence, Biological Properties and Spectroscopic Data

Tain M. Arrospide; Lucas H. N. Sousa; Marcela C. N. Diniz; Fabrcio G. Menezes; Renata M. Arajo

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Spectroscopic, chemical and biological data published between 1965-2022 on acylphloroglucinol derivatives are compiled in this review.

https://dx.doi.org/10.21577/0103-5053.20240021

Published online: February 15, 2024

 

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Articles J. Braz. Chem. Soc. 2024, 35(7), e-20230170, 1-7

Real-Time Monitoring of Nitrogen Oxides Emission Factors Using Sensors in the Exhaust Pipes of Heavy Vehicles in the Metropolitan Region of Rio de Janeiro

Luis F. M. Silva ; Alex R. H. De La Cruz; Andr H. M. Nunes; Adriana Gioda

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NOx emission factors of heavy vehicles were measured through a sensor and compared to legislation.

https://dx.doi.org/10.21577/0103-5053.20230170

Published online: October 24, 2023

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240004, 1-13

Smart Films Produced by Electrospinning of Poly(butylene-adipate-co‑terephthalate)/poly-(ε-caprolactone) for Controlled Delivery of Ibuprofen

Janice C. Hardt; Gabriel N. Fraga; Alessandra R. Medeiros ; Ariane R. S. Rossin; Josiane Caetano; Matheus C. O. Leite;
Bruno V. L. da Fonseca; Bruno H. Vilsinski ; Douglas C. Dragunski

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Microfibers of poly(butylene-adipate-co-terephthalate) (PBAT) and poly-(ε-caprolactone) (PCL) containing ibuprofen were obtained by electrospinning technique. The material revealed potential for transdermal application.

https://dx.doi.org/10.21577/0103-5053.20240004

Published online: January 10, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240005, 1-9

A Scalable Total Synthesis of Deoxyrhapontigenin from Low-Cost α-Resorcylic Acid

Yuri F. Rego ; ngelo de Ftima

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A seven-step high yielding process from low cost α-resorcylic acid to obtain deoxyrhapontigenin is presented. Intermediaries for divergent strategies and structures are also obtained in high yields.

https://dx.doi.org/10.21577/0103-5053.20240005

Published online: January 12, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240006, 1-8

Determining Tolfenpyrad in Water Samples Using Liquid-Liquid Extraction with Low Temperature Purification (LLE-LTP)

Karine R. Tefilo; Lzaro C. Sicupira ; Flaviano O. Silvrio

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This study optimizes and validates liquid-liquid extraction with low temperature purification (LLE-LTP) for the first time to determine tolfenpyrad in water.

https://dx.doi.org/10.21577/0103-5053.20240006

Published online: January 15, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240007, 1-10

PdAg/CoFe2O4 Bimetallic Catalyst with High Selectivity for Glyceraldehyde in Glycerol Selective Oxidation Reaction

Milton S. Falco ; Edmilson M. de Moura ; Jean C. S. Costa ; Antonio F. A. A. Melo; Gilvan M. Paz; Ronaldo F. do Nascimento ; Hlio O. do Nascimento; Luciano A. Montoro

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Sequenced oxidation of glycerol forming glyceraldehyde, glyceric acid, tartronic acid and mesoxalic acid catalyzed by bimetallic silver and palladium nanoparticles anchored on the cobalt ferrite surface.

https://dx.doi.org/10.21577/0103-5053.20240007

Published online: January 16, 2024

 

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Total access: 331


J. Braz. Chem. Soc. 2024, 35(7), e-20240008, 1-8

Development and Validation of a Method to Analyze Fentanyl and Its Analogues in Postmortem Blood Samples by LC-MS/MS

Tas B. Rodrigues ; Mrcio H. Matsubara; Elvis M. Aquino; Victor A. P. Gianvecchio; Damila R. Morais; Jose Luiz Costa

How to cite this article

 

Quantitation method to analyze fentanyl and seven analogues in postmortem blood samples by protein precipitation and liquid chromatography-tandem mass spectrometry.

https://dx.doi.org/10.21577/0103-5053.20240008

Published online: January 19, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240009, 1-19

Exploring Energy-Efficient Techniques and Chemical Kinetics in Reactive Nitrogen Species Production with Ambient Air Plasma for Plasma-Activated Water

rica T. Berlatto; Pricles I. Khalaf

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The image presents a vortex-operated plasma reactor, UV-spectra and chemical kinetics data, culminating in the determinant step for HNO3(aq) production.

https://dx.doi.org/10.21577/0103-5053.20240009

Published online: January 24, 2024

 

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Total access: 267


J. Braz. Chem. Soc. 2024, 35(7), e-20240010, 1-10

1H NMR Chemical Profile and Antioxidant Activity of Eugenia punicifolia Extracts Over Seasons:
A Metabolomic Pilot Study

Kidney O. G. Neves; Maria F. C. Santos; Josiana M. Mar; Flvia L. D. Pontes; Claudio F. Tormena; Francisco C. M. Chaves;
Francinete R. Campos; Edgar Aparecido Sanches; Jaqueline A. Bezerra ; Marcos B. Machado ; Alan D. C. Santos

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Unlocking seasonal fluctuations in the chemical profile of Eugenia punicifolia through 1H nuclear magnetic resonance and multivariate analysis. Dimethyl sulfoxide (DMSO) leaf extracts revealed distinct chemical profiles and antioxidant activities across seasons, providing insights into the defense mechanisms of the plant.

https://dx.doi.org/10.21577/0103-5053.20240010

Published online: January 24, 2024

 

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Total access: 568


J. Braz. Chem. Soc. 2024, 35(7), e-20240011, 1-8

Evaluation of Intestinal Permeability of the Antifungal Compound PD76: Comparison of in silico Platforms and in vitro Assay in Caco-2 Cell Model

Isabella C. Pierotte; Iara R. Silva; Valtair S. dos Santos Jr.; Gabriel P. Almeida; Pedro Henrique G. dos Santos; Vincius G. Maltarollo; Renata B. de Oliveira; Jos Eduardo Gonalves ; Isabela Costa Csar

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2-Hydrazinyl-4-(4-methoxyphenyl)thiazole (PD76) intestinal permeability was assessed by means of the comparison of in vitro assay in Caco-2 cells and in silico platforms.

https://dx.doi.org/10.21577/0103-5053.20240011

Published online: January 25, 2024

 

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Total access: 354


J. Braz. Chem. Soc. 2024, 35(7), e-20240013, 1-9

Sodium Glyceroxide: An Efficient Homogeneous Alkaline Catalyst for Biodiesel Synthesis

Samuel J. Santos ; Joo V. Braun; Guilherme C. Espndola; Josu A. da Silva; Rodrigo E. Renner; Luiz A. M. Fontoura

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Sodium glyceroxide is a cheap, stable, and safe homogeneous alkaline catalyst for the alcoholysis of triglycerides.

https://dx.doi.org/10.21577/0103-5053.20240013

Published online: January 25, 2024

 

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Total access: 296


J. Braz. Chem. Soc. 2024, 35(7), e-20240014, 1-11

Investigating Solvent-Induced Changes in Structure and Nonlinear Optical Behavior of Thiazine Derivatives

Clodoaldo Valverde ; Andr D. da Silva; Krishna M. Potla; Heibbe C. B. de Oliveira; Francisco A. P. Osrio; Baslio Baseia

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This study investigates the impact of solvent media on the structural and optical behaviors of two isomers of thiazine derivatives. We analyze the effects of relocating the NO2 group within the isomers and its implications on molecular geometries, optical parameters, and gap energies across different solvent environments. Bond dissociation energy calculations and various analytical insights further contribute to our understanding of these derivatives.

https://dx.doi.org/10.21577/0103-5053.20240014

Published online: January 29, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240015, 1-11

Evaluation of the Amazon River Seasonal Influences on Glycerophospholipids in Wild Fish

Banny S. B. Correia ; Joo Guilherme M. Pontes; Raquel Susana Torrinhas; Adalberto Luis Val; Christopher Paul Thomas;
Ljubica Tasic

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Glycerophospholipid profiles of wild Amazonian fish observed through mass spectrometry by analyzing season (drought and flood) influences.

https://dx.doi.org/10.21577/0103-5053.20240015

Published online: January 30, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240016, 1-12

Annotation of Alkaloids of Fusaea longifolia and Evaluation of Anti-Plasmodium Activity in vitro and in silico

Asenate A. X. Adrio; Carlos V. A. da Silva ; Morgana S. Araujo; Weider H. P. Paz; Lvia S. de Medeiros; Felipe M. A. da Silva; Daniel P. Bezerra; Zeca M. Salimo; Wuelton M. Monteiro; Gisely C. de Melo; Emmanoel V. Costa; Josean F. Tavares ; Hector H. F. Koolen

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The alkaloid fractions of Fusaea longifolia showed high anti-Plasmodium activity and moderate cytotoxic activity. Through characterization via liquid chromatography coupled to mass spectrometry (LC-MS/MS) and using molecular networks, these fractions proved to be promising sources of isoquinoline alkaloids. Based on the molecular docking approach, these alkaloids demonstrated inhibition potential against target enzymes of the Plasmodium falciparum parasite.

https://dx.doi.org/10.21577/0103-5053.20240016

Published online: January 30, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240017, 1-11

Pharmacophore Modeling for Pleurotin Derivatives Targeting Human Thioredoxin Reductase

Daniel B. Quintanilha; Hlio F. Dos Santos

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Pleurotin (left) is a potent inhibitor of the thioredoxin reductase (TrxR) enzyme, a target for cancer chemotherapy. This work proposes a new derivative (right) that is ca. 40% more active against TrxR than pleurotin.

https://dx.doi.org/10.21577/0103-5053.20240017

Published online: January 31, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240019, 1-16

Stealth Behavior of Poly(ethyloxazoline)s-Modified Hydroxyethyl Starch-Based Nanocapsules

Lillian M. U. D. Fechine; Biao Kang; Susanne Schttler; Denise R. Moreira; Danilo C. Queiroz; Frederik R. Wurm; Katharina Landfester; Ngila M. P. S. Ricardo

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Poly(oxazoline)s coupled hydroxyethyl starch nanocapsules were developed by inverse miniemulsion via interfacial polyaddition in order to create a powerful protein suppressor vehicle.

https://dx.doi.org/10.21577/0103-5053.20240019

Published online: February 8, 2024

 

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J. Braz. Chem. Soc. 2024, 35(7), e-20240020, 1-14

Use of Biochemical Tests and Machine Learning in the Search for Potential Diagnostic Biomarkers of COVID-19, HIV/AIDS, and Pulmonary Tuberculosis

Alexandre F. Cobre; Amiel A. Morais; Fosfato Selege; Dile P. Stremel; Astrid Wiens; Luana M. Ferreira; Fernanda S. Tonin;
Roberto Pontarolo

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The machine learning model discriminant analysis by partial least squares (PLS-DA) was capable of predicting the diagnosis of coronavirus disease (COVID-19), human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), tuberculosis (TB), and HIV/TB co-infection patients with high accuracy and identifying potential biomarkers associated with the diagnosis.

https://dx.doi.org/10.21577/0103-5053.20240020

Published online: February 15, 2024

 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

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