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Current Issue vol. 36, No. 4, 2025

 

Development of fluorescent deoxyribonucleic acid (DNA) probes derived from lapachol, a naphthoquinone extracted from the yellow ipe tree. Novel fluorophore naphthoxazoles were synthesized, demonstrating the ability to interact with DNA via groove binding. Details are presented in the Article Naphthoxazoles Derived from Lapachol as Fluorescent DNA Probes: Synthesis and Binding Studies with Calf Thymus DNA by Délis G. Guimarães, Victória L. A. Santos, Sidney S. Simplicio, Arlan A. Gonsalves, João J. S. Gouveia, Fernanda B. Almeida, Luiza A. Gusmão, Antonio C. Tedesco, Fernando L. Primo, Larissa A. Rolim and Cleônia R. M. Araújo on e-20240188.


Cover Article
J. Braz. Chem. Soc. 2025, 36(4), e-20240188, 1-12

Naphthoxazoles Derived from Lapachol as Fluorescent DNA Probes: Synthesis and Binding Studies with Calf Thymus DNA

Délis G. Guimarães; Victória L. A. Santos; Sidney S. Simplicio; Arlan A. Gonsalves; João J. S. Gouveia; Fernanda B. Almeida;
Luiza A. Gusmão; Antonio C. Tedesco; Fernando L. Primo; Larissa A. Rolim; Cleônia R. M. Araújo

How to cite this article

Development of fluorescent deoxyribonucleic acid (DNA) probes derived from lapachol, a naphthoquinone extracted from the yellow ipe tree. Novel fluorophore naphthoxazoles were synthesized, demonstrating the ability to interact with DNA via groove binding. Details are presented in the Article Naphthoxazoles Derived from Lapachol as Fluorescent DNA Probes: Synthesis and Binding Studies with Calf Thymus DNA by Délis G. Guimarães, Victória L. A. Santos, Sidney S. Simplicio, Arlan A. Gonsalves, João J. S. Gouveia, Fernanda B. Almeida, Luiza A. Gusmão, Antonio C. Tedesco, Fernando L. Primo, Larissa A. Rolim and Cleônia R. M. Araújo on e-20240188.

https://dx.doi.org/10.21577/0103-5053.20240188

Published online: September  20, 2024
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Editorial J. Braz. Chem. Soc. 2025, 36(4), e-20250030, 1-5

The Northern Region of Brazil and the Journal of the Brazilian Chemical Society: Past, Present, and Future

Giovana A. Bataglion ; Hector H. F. Koolen

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https://dx.doi.org/10.21577/0103-5053.20250030

Total access: 405


Review J. Braz. Chem. Soc. 2025, 36(4), e-20240223, 1-19

Conventional and Biological Direct Glycerol Fuel Cells: Review on Main Experimental and Model-Based Achievements

Alessandra Pezzini ; Ruy de Sousa Júnior

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Application of glycerol as a fuel in conventional and biological (enzymatic and microbial) fuel cells, and their main products.

https://dx.doi.org/10.21577/0103-5053.20240223

Published online: December 12, 2024

 

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Articles J. Braz. Chem. Soc. 2025, 36(4), e-20240173, 1-8

Allelopathic Influence of Artemisia lancea Essential Oil on Selected Broad and Narrow Weeds

Zixiang Shan; Shixing Zhou; Yasir Arafat; Kai Shi; Hua Shao

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The chemical profile of Artemisia lancea essential oil detected by gas chromatography-mass spectrometry (GC-MS) and its allelopathic influence on seedling growth of Amaranthus retroflexus and Setaria viridis.

https://dx.doi.org/10.21577/0103-5053.20240173

Published online: August 26, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240174, 1-13

Development of New Thio-Functionalized Resins for the Study of Confinement of High Solubility Nanoparticles: An Alternative to Reduce the Future Ecological Impact

César Díaz-Cruz; Ignacio A. Rivero ; Karla A. Espinoza; Alberto Pérez-Zamora; Hector Daniel Ibarra-Prieto ;
Alejandra Garcia-Garcia

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New thio-functionalized resins have the capacity for the confinement of gold nanoparticles and the catalytic reduction of nitro aromatics.

https://dx.doi.org/10.21577/0103-5053.20240174

Published online: August 27, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240175, 1-9

Extraction Mechanism of Hesperidin from Citrus aurantium L. Using a Novel Deep Eutectic Solvent: Experimental and Theoretical Investigation

Jun Zhou ; Jinbao Tang

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A novel deep eutectic solvent has excellent extraction effect on hesperidin, due to its strong dissolving capacity, easy formation of
H-bonds and van der Waals forces with hesperidin.

https://dx.doi.org/10.21577/0103-5053.20240175

Published online: August 28, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240176, 1-12

Structural and Biochemical Characterization of Levan Produced by Gluconobacter cerinus UELBM11 Isolated from Brazilian Grapes

Natália N. Y. Hata ; Daniele Sartori; Matheus M. Ribeiro; Rodrigo V. Serrato; Adriana Aparecida B. Tomal;
Leonel Vinícius Constantino ; Mariana A. Q. Cancian; Francisco A. Marques ; Fernando T. Hata;
Fernanda Carla H. Bana; Fernando Macedo Jr.; Wilma Aparecida Spinosa

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Levan produced by Gluconobacter cerinus was structurally characterized and evaluated for its antioxidant activity.

https://dx.doi.org/10.21577/0103-5053.20240176

Published online: August 30, 2024

 

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Total access: 610


J. Braz. Chem. Soc. 2025, 36(4), e-20240177, 1-11

CO2 Adsorption on Nanocomposite Pollen-Derived Carbons: Synergic Effect of KOH Activation and MgO Incorporation

Francisco Granados-Correa ; Juan Bonifacio-Martínez ; Melania Jiménez-Reyes

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CO2 adsorption on nanocomposite pollen-derived carbons.

https://dx.doi.org/10.21577/0103-5053.20240177

Published online: August 30, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240178, 1-8

Determination of Lisdexamfetamine in Human Plasma by LC-MS/MS Method

Alex A. R. Silva ; Lilia L. D. Coelho; Karen Y. Sánchez-Luquez; Pedro H. D. Garcia ; Renata Boldin; Anne M. R. Silveira;
Marcia A. Antonio; Andreia M. Porcari ; Patrícia O. Carvalho

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Development and validation of lisdexamfetamine using liquid chromatography-tandem mass spectrometry (LC-MS/MS) system applied for pharmacokinetic studies.

https://dx.doi.org/10.21577/0103-5053.20240178

Published online: September 4, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240180, 1-16

Development of a Multianalyte Method for the Determination of Phenolic Compounds in Residues from Beverage Production Using a Cyclofructan-Based Column in HILIC-MS/MS

Mayara da Silva; Maressa D. Dolzan; Gustavo A. Micke; Luciano Vitali

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This study proposes a method for the simultaneous determination of 31 phenolic compounds by hydrophilic interaction chromatography coupled with triple quadrupole mass spectrometry (HILIC-MS/MS) and its application in residues from the beverage industry.

https://dx.doi.org/10.21577/0103-5053.20240180

Published online: September 9, 2024

 

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Total access: 584


J. Braz. Chem. Soc. 2025, 36(4), e-20240183, 1-17

Exploring the Corrosion Inhibition Potential of Plant Extracts from Parts of Hymenaea courbaril on
Carbon Steel in 0.5 mol L-1 H2SO4

Everton B. Policarpi ; Almir Spinelli

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Aqueous extracts of Hymenaea courbaril are effective corrosion inhibitors, especially the fractions from the leaves and fruit pulp due to their higher content of phenolics.

https://dx.doi.org/10.21577/0103-5053.20240183

Published online: September 13, 2024

 

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Total access: 516


J. Braz. Chem. Soc. 2025, 36(4), e-20240184, 1-15

Green and Effective: Chitosan Blends with Fish Collagen and Aloe vera Exudate

Pâmella R. L. C. Gonçalves; Rosiane S. Penha; Jaciene J. F. Cardoso; Amanda R. Guimarães; Cícero Wellington B. Bezerra

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This work consists of proposing simple and selective routes for chitosan-based blends with fish collagen and Aloe vera exudate.

https://dx.doi.org/10.21577/0103-5053.20240184

Published online: September 16, 2024

 

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Total access: 390


J. Braz. Chem. Soc. 2025, 36(4), e-20240185, 1-7

Research and Application of TLC Identification Method for Homoisoflavanones in Polygonatum odoratum (Mill.) Druce

Jialin Zang; Gang Li; Chaoyang Zhao; Zhen Lv

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We developed a rapid and efficient thin-layer chromatography method for detecting homoisoflavones in Polygonatum odoratum (Mill.) Druce, which exhibits extremely high sensitivity, specificity, and stability.

https://dx.doi.org/10.21577/0103-5053.20240185

Published online: September 17, 2024

 

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Total access: 388


J. Braz. Chem. Soc. 2025, 36(4), e-20240186, 1-13

Additively Manufactured Collector-Detector Device for Explosive Analysis Using Recycled PLA Filament Loaded with Carbon Black and Graphite

Maria M. C. Souza; Gilvana P. Siqueira; Raquel G. Rocha; Robert D. Crapnell; Mário H. P. Santana; Eduardo M. Richter;
Craig E. Banks; Rodrigo A. A. Muñoz

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We present a collector-detector device for the electrochemical analysis of explosives in post-explosion residues fabricated by a desktop 3D printer and a conductive filament made of recycled polylactic acid (PLA), carbon black and graphite.

https://dx.doi.org/10.21577/0103-5053.20240186

Published online: September 17, 2024

 

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Total access: 620


J. Braz. Chem. Soc. 2025, 36(4), e-20240187, 1-11

Nanoemulsion of Kefiran and Coriander (Coriandrum sativum L.) Essential Oil: Chemical and Technological Aspects

Gizele A. Cruz; Elano N. Ferreira; Fernando Eugenio T. Cunha; Celli R. Muniz; Hélio O. do Nascimento; Ronaldo F. do Nascimento ; Larissa M. R. da Silva; Nágila Maria P. S. Ricardo ; Juliane D. G. Carvalho

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Development of a nanoemulsion based on kefiran and coriander essential oil to stabilize the essential oil compounds and preserve their antimicrobial properties to increase the stability of ricotta cheese.

https://dx.doi.org/10.21577/0103-5053.20240187

Published online: September 19, 2024

 

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Total access: 561


J. Braz. Chem. Soc. 2025, 36(4), e-20240188, 1-12

Naphthoxazoles Derived from Lapachol as Fluorescent DNA Probes: Synthesis and Binding Studies with Calf Thymus DNA

Délis G. Guimarães; Victória L. A. Santos; Sidney S. Simplicio; Arlan A. Gonsalves; João J. S. Gouveia; Fernanda B. Almeida;
Luiza A. Gusmão; Antonio C. Tedesco; Fernando L. Primo; Larissa A. Rolim; Cleônia R. M. Araújo

How to cite this article

 

New fluorophore naphthoxazoles were synthesized from lapachol and investigated for their potential application as deoxyribonucleic acid (DNA) fluorescent probes.

https://dx.doi.org/10.21577/0103-5053.20240188

Published online: September 20, 2024

 

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Total access: 642


J. Braz. Chem. Soc. 2025, 36(4), e-20240189, 1-11

Investigating the Cytotoxic, Apoptotic, Treatment-Resistant, and Inflammatory Response Properties of a Gold(III) Complex Containing a Tetradentate Schiff Base Ligand

Xiaoling Zhang; Ke Wei; Mostafa Heidari Majd ; Somaye Shahraki ; Xiaojuan Zhao

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The gold(III) Schiff base complex reduces the expression of the AKT1 gene, leading to an increase in the expression of the apoptosis-promoting gene Bak1. In contrast, cisplatin increases the expression of the AKT1 gene, followed by an increase in the anti-apoptotic Bclx gene, resulting in treatment resistance.

https://dx.doi.org/10.21577/0103-5053.20240189

Published online: September 20, 2024

 

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Total access: 548


J. Braz. Chem. Soc. 2025, 36(4), e-20240190, 1-10

Chitosan Films with Morphology Modified by Cellulose Nanofibers Investigated by SERS Spectroscopy

Amanda C. Marques; Daphne F. C. Lanferini; Leonara Fayer ; Benjamin Fragneaud; Michele Munk ; Antonio Carlos Sant'Ana

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Chemical interactions of chitosan and cellulose-nanofiber/chitosan films with silver nanoparticles investigated through surface-enhanced Raman scattering (SERS) spectroscopy.

https://dx.doi.org/10.21577/0103-5053.20240190

Published online: September 26, 2024

 

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Total access: 547


J. Braz. Chem. Soc. 2025, 36(4), e-20240191, 1-10

Synthesis and Characterization of Double Calcium Iron Phosphate from Chicken Eggshell

Luiz Claudio S. Gomes; Rhayra Braga; Diego P. Aguiar; Leonardo R. Andrade; Amanda S. Cavalcanti; Marcos V. Colaço;
João Antonio M. Guimarães; Juliana F. Lima

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Double calcium iron phosphate [Ca9Fe(PO4)7] obtained from chicken eggshell.

https://dx.doi.org/10.21577/0103-5053.20240191

Published online: September 27, 2024

 

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Total access: 514


J. Braz. Chem. Soc. 2025, 36(4), e-20240192, 1-21

In silico Screening of Monamine Oxidase B Inhibitors for the Treatment of Central Nervous System Disorders

Anderson L. P. da Costa ; Henrique B. Lima; Ana C. J. Silva; Gabrieli S. Oliveira; Mariana P. Barcelos; Carlos H. T. P. da Silva;
Lorane I. S. Hage-Melim

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Four potential selective monoamine oxidase B (MAO-B) inhibitors were identified by screening compounds in the chemical space of molecular databases using in silico techniques.

https://dx.doi.org/10.21577/0103-5053.20240192

Published online: September 30, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240193, 1-9

Lipase-Catalyzed Synthesis of Citronellyl Esters by Different Acylating Agents: A Kinetic Comparison Study

Amanda Staudt ; Camila R. A. Malafaia; Ana D. N. P. Georgii ; Ivaldo Itabaiana Jr. ; Ivana C. R. Leal

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Efficient production of citronellyl esters through esterification and transesterification catalyzed by Novozym®435 via linear acylating agents (C3-C18) with kinetic modelling, product isolation and reuse of the biocatalyst.

https://dx.doi.org/10.21577/0103-5053.20240193

Published online: October 4, 2024

 

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Total access: 526


J. Braz. Chem. Soc. 2025, 36(4), e-20240212, 1-13

Rapid Synthesis of Novel Pyrazino-Pyrido-Pyrimidinones Derived from Fumiquinazoline Alkaloids

Marcelo F. Marchiori ; Ivone Carvalho

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2,5-Diketopiperazine-derived quinazolinones are key structures in fumiquinazoline alkaloids, known by their pyrazino[1,2-b]quinazoline-3,6-dione framework and notable biological activities. In this study, we synthesized 19 novel fumiquinazoline-like analogs, divided into three series (A, B, and C), with a modified pyrazino-pyrido-pyrimidinone core, offering potential for further biological research.

https://dx.doi.org/10.21577/0103-5053.20240212

Published online: November 13, 2024

 

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Total access: 447


J. Braz. Chem. Soc. 2025, 36(4), e-20240213, 1-15

Lipid Composition and Cytokines IL-10 and TGF-β1 Evaluation of Prebiotic Ice Cream Containing Human Milk

Matheus C. Castro; Eloize S. Alves; Bruno Henrique F. Saqueti; Cintia Stephany R. Ferreira; Joana Maira V. Zacarias; Jeane Eliete L. Visentainer; Grasiele S. Madrona; Oscar O. Santos ; Jesui V. Visentainer

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Study of the lipid quality and cytokines interleukin-10 (IL-10) and transforming growth factor-beta 1 (TGF-β1) of ice cream containing human milk.

https://dx.doi.org/10.21577/0103-5053.20240213

Published online: November 13, 2024

 

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Total access: 468


J. Braz. Chem. Soc. 2025, 36(4), e-20240214, 1-8

Simple and Low-Cost Method for Quantifying Total Phenolic Compounds in Extra Virgin Olive Oils Using Digital Images

Aline M. Vieira; Bruna R. S. Gomes; Kauanny Beatriz N. Braga; Jandyson M. Santos

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This study developed a simple, fast and low-cost method for the quantification of total phenolic content (TPC) in extra virgin olive oil samples (EVOOs), using an optimized colorimetric reaction with the Folin-Ciocalteu reagent and the acquisition of digital images with a smartphone.

https://dx.doi.org/10.21577/0103-5053.20240214

Published online: November 21, 2024

 

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Total access: 477


J. Braz. Chem. Soc. 2025, 36(4), e-20240215, 1-10

Antimicrobial and Antibiofilm Activities of the Essential Oil from the Inflorescence of Etlingera elatior (Zingiberaceae) and Its Main Constituents (Dodecanal and 1-Dodecanol)

Felipe S. Ferreira; Ana C. da Silva ; Júlio C. R. O. F. de Aguiar ; Maiara C. de Moura; Camila S. L. Pimentel ;
Luana C. B. B. Coelho ; Patricia M. G. Paiva ; Thiago H. Napoleão ; Daniela M. A. F. Navarro

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Antimicrobial and antibiofilm activities of the essential oil from the inflorescence of Etlingera elatior (Zingiberaceae) and its main constituents (dodecanal and 1-dodecanol).

https://dx.doi.org/10.21577/0103-5053.20240215

Published online: November 25, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240224, 1-12

Acridone Derivatives as Photosystem II Inhibitors: Synthesis, Herbicidal Activity, and Structure-Activity

Jessica Maria de Souza ; Paulo S. Medeiros ; Taciane S. Pitteri ; Mariana A. Silva ; Marcelo Augusto F. Basso;
Leonardo G. de Vasconcelos ; Evandro Luiz Dall'Óglio ; Olívia M. Sampaio ; Lucas C. C. Vieira

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This study presents the synthesis of acridone derivatives and their evaluation as photosystem II inhibitors and herbicides. Among the tested compounds, acridin-9(10H)-one demonstrated the best photosystem II (PSII) inhibition, while 2-chloroacridin-9(10H)-one and 9(10H)-acridone-4-carboxylic acid exhibited herbicidal activity against Amaranthus species. Molecular docking analysis indicated that carbonyl groups and aromatic substituents are essential for ligand interactions, providing insights for designing new bioactive scaffolds.

https://dx.doi.org/10.21577/0103-5053.20240224

Published online: December 16, 2024

 

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J. Braz. Chem. Soc. 2025, 36(4), e-20240225, 1-10

Synthesis of PLA-PEG Copolymers Containing Folic Acid and Fluorescein by Ugi Reaction

Joana S. von der Weid ; Taylor F. P. Gomes; Luis P. Icart; Marcos L. Dias

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The synthesis of two poly(lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) block copolymers using the Ugi multicomponent reaction is described. Folic acid and fluorescein frameworks were introduced as targeting and fluorescent marker aiming further application in the controlled release of drugs for cancer therapy.

https://dx.doi.org/10.21577/0103-5053.20240225

Published online: December 19, 2024

 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

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