JBCS

OncoTherad (MRB-CFI-1), a novel nanoimmunotherapy developed in Brazil, activates innate immune system toll like receptors pathways to enhance antitumor immunity. This cost-effective innovation exemplifies scalable immunotherapy from the Global South.

Mass spectrometry-based metabolomics for the development of bioinputs: a review on plant growth-promoting yeasts.

This graphical abstract depicts the environmental and anthropogenic factors contributing to the degradation of face masks into microplastics and nanoplastics, highlighting their potential pathways across urban and natural ecosystems.

The figure presents the methodological flow of the study of the volatile chemical constituents of Myrciaria tenella. The botanical identification of the species was performed, followed by the extraction of volatile compounds by hydrodistillation. The samples were analyzed by gas chromatography coupled with mass spectrometry to identify (E)-caryophyllene, δ-cadinene, α-calacorene, caryophyllene oxide, and 1-epi-cubenol. Finally, the data obtained were subjected to multivariate statistical analyses.

Simulated UV-Vis absorption spectrum of probe and sulfite adduct based on PBE0/def2TZVPD method.

Binding mode of compound 16d (potential inhibitor) in the active site of the dissimilatory adenosine 5'-phosphosulfate reductase (APSrAB).

Melaleuca alternifolia essential oil nanoemulsion was developed for pharma cosmetic applications, with a detailed analysis of its components, thermal stability evaluation, and droplet size characterization.

Malt bagasse residue is converted by sustainable method into P-doped hydrochar and applied as support of Co-Ni nanocatalysts for H₂ evolution.

In general, in the upper Doce River, the concentration of As, Cr, Cu, Fe, Mn, Ni, and Pb exceeds the maximum limits of the Brazilian Resolution in the rainy season.

The polydimethylsiloxane/polyvinylidene fluoride (PDMS/PVDF) membrane had the best hydrophobicity (145.2°), and the separation efficiency could still reach 95.0% after 20 cycles.

Laser-induced breakdown spectroscopy (LIBS) and hyperspectral imaging enable real-time monitoring and control of metal leaching from e-waste, supporting efficient and sustainable resource recovery.

Binding of ligands to the Chromobox 4 (CBX4) protein to prevent potential oxidative stress and noise-induced deafness.

The physical and chemical stability of emulsions containing a piceatannol-rich extract from passion fruit seeds, a spilanthol-rich extract from paracress, and UV filters was assessed by UV-Vis, analytical centrifugation, thermal analyses, and exposure to temperature cycles.

Natural organic residues enriched with Ca and Mg for application in lettuce grown in water depths demonstrated positive results in crop growth and development.

Secondary metabolites from species of the Spondias genus were evaluated as potential inhibitors of monoamine oxidase A (MAO-A) through molecular docking studies and in vitro assays. The results revealed high binding affinity and enzyme inhibition, suggesting promising candidates for the treatment of depression.

A new recycling route for polyethylene terephthalate (PET) waste was developed through its partial depolymerization with glycerol, yielding a material with potential adsorbent properties.

This study reports the synthesis and biological evaluation of a series of 2-(quinolin-4-yloxy) acetamides as antitubercular agents. The work highlights the structure-activity relationships, cytotoxicity, and aqueous solubility of the most active derivatives, identifying compound 6o as a valuable scaffold for future medicinal chemistry efforts.

Sewage sludge and wheat straw were synergistically converted via hydrothermal carbonization. The optimal condition (200 °C, 2:1 ratio) yielded hydrochar with superior combustion performance.

We propose an optimized version of the Magre-II tool for predicting aggregation regions in proteins using machine learning.

The impedance modulus of the samples at 0.01 Hz exceeds 10⁶ Ω after adding magnesium phosphate, which is one order of magnitude higher than that without adding magnesium phosphate and two orders of magnitude higher than that of bare 2024 aluminum alloy.

This work demonstrates the effects of the ursolic acid/polycyclodextrin complex, which reduced nitric oxide production in vitro and attenuated the clinical severity of experimental autoimmune encephalomyelitis, showing an anti-inflammatory profile similar to isolated ursolic acid.

A low-cost Arduino automated electrochemical reactor was developed for graphene oxide (GO) synthesis via electrochemical exfoliation of graphite.

Encapsulation of [Pd(dipic)₂]^2- (dipic: dipicolinic acid) within folic acid-modified magnetic halloysite nanotubes (MHNTs-FA) triggers both intrinsic and extrinsic apoptosis pathways, significantly downregulating AKT1, a key protein in cell survival and drug resistance. In contrast, free [Pd(dipic)₂]^2- fails to overcome resistance.

The graphical abstract illustrates the workflow of a virtual screening study targeting Leishmania triosephosphate isomerase (TIM), highlighting protein selection, compound docking, molecular dynamics and in vitro validation.

Environmental chamber used to sample primary pollutants and convert them into secondary pollutants using UV lamps to simulate sunlight.

The composition of fatty acids and antioxidants in dry extruded food for dogs and cats using gas chromatography flame ionization detector (GC-FID) and high-performance liquid chromatography with a diode-array detector (HPLC-DAD) techniques.

When 4-mercaptobenzoic acid (4-MBA) concentration decreases, the molecules reorient, leading to interaction of the carboxylate group with the gold nanoparticles (AuNP) surface, besides the thiolate interaction, as probed by surface-enhanced Raman scattering (SERS).

This study employs quantitative structure-activity relationship (QSAR)-based machine learning models, validated with bioactivity data (half-maximal inhibitory concentration (IC₅₀)) for dopaminergic and serotonergic receptors, to screen US Food and Drug Administration (FDA)-approved compounds as candidates for multitarget drug repurposing in the treatment of neuropsychiatric disorders.