JBCS

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Current Issue vol. 36, No. 11, 2025

 

This robotic system combines open-source hardware and 3D printing to democratize automated liquid handling. It integrates colorimetric and electrochemical detection for multi-analyte quantification (e.g., glucose, nitrite, phosphate) with minimal user intervention, serving environmental, agricultural, and biological applications. Modular and cost-effective, it pioneers self-operating laboratories in resource-limited regions. Details are presented in the Full Paper 3D-Printed Liquid Handling Robot for the Development of Automated Analytical Methods by Aline D. Assunção, Diogo M. de Jesus, Teodoro R. Terra, Raquel G. Rocha, José A. M. G. Costa, Luiz A. J. da Silva, Guilherme L. Fernandes, Alessandro G. C. Dias, Rodrigo A. A. Muñoz, Sidnei G. Silva and Eduardo M. Richter on e-20250114.


Cover Article
J. Braz. Chem. Soc. 2025, 36(11), e-20250114, 1-11

3D-Printed Liquid Handling Robot for the Development of Automated Analytical Methods

Aline D. Assunção ; Diogo M. de Jesus ; Teodoro R. Terra; Raquel G. Rocha ; José A. M. G. Costa; Luiz A. J. da Silva;
Guilherme L. Fernandes; Alessandro G. C. Dias; Rodrigo A. A. Muñoz ; Sidnei G. Silva ; Eduardo M. Richter

How to cite this article

This robotic system combines open-source hardware and 3D printing to democratize automated liquid handling. It integrates colorimetric and electrochemical detection for multi-analyte quantification (e.g., glucose, nitrite, phosphate) with minimal user intervention, serving environmental, agricultural, and biological applications. Modular and cost-effective, it pioneers self-operating laboratories in resource-limited regions. Details are presented in the Full Paper 3D-Printed Liquid Handling Robot for the Development of Automated Analytical Methods by Aline D. Assunção, Diogo M. de Jesus, Teodoro R. Terra, Raquel G. Rocha, José A. M. G. Costa, Luiz A. J. da Silva, Guilherme L. Fernandes, Alessandro G. C. Dias, Rodrigo A. A. Muñoz, Sidnei G. Silva and Eduardo M. Richter on e-20250114.

https://dx.doi.org/10.21577/0103-5053.20250114

Published online: July  15, 2025
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Editorial J. Braz. Chem. Soc. 2025, 36(11), e-20250147, 1

The JBCS as Heritage of Brazilian Science. We Should All Take Care of It

Ronaldo A. Pilli

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https://dx.doi.org/10.21577/0103-5053.20250147

Total access: 311


Communication J. Braz. Chem. Soc. 2025, 36(11), e-20250117, 1-12

Green Tools Based on Graphitic-Like Carbon/TiO2/CaCO3 Biocomposites as a High-Performance Platform for CO2 Capture

Angélica G. Oliveira ; Glaucio José Gomes ; Lucas Spessato ; Paulo Rodrigo S. Bittencourt ; Janine C. Padilha ;
Caroline C. S. Gonçalves

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Cigarette filters were pyrolyzed to obtain bio-oil and biochar aiming at efficient CO2 adsorption.

https://dx.doi.org/10.21577/0103-5053.20250117

Published online: July 21, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250140, 1-7

Late-Stage Deoxygenative Olefination in the Synthesis of Stachene Diterpenoids

Lucas D. P. Gonçalves ; Deborah A. Simoni ; Emilio C. de Lucca Jr.

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Through a two-step deoxygenative olefination approach, we synthesized three stachene natural products from isosteviol, including the first reported synthesis of (+)-nidoanomalin.

https://dx.doi.org/10.21577/0103-5053.20250140

Published online: September 2, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250145, 1-8

Raman Spectroscopy as a Tool for the Characterization of Pyrrole and Indole Cyanation via Vilsmeier-Haack Reaction

Mariana T. C. Campos ; Vinícius R. D. Pereira ; Geovana F. Vargas; Maira G. R. Pitta ; Breno C. de Araujo ;
Luiz F. C. de Oliveira ; Giovanni W. Amarante

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The figure illustrates the in situ Raman spectroscopic monitoring of the Vilsmeier-Haack cyanation of pyrrole and indole. The visual flow represents the progression of the reaction through substrates, intermediates, and finally, the products, with Raman spectra evidencing the molecular transformations.

https://dx.doi.org/10.21577/0103-5053.20250145

Published online: September 12, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250149, 1-8

Fabrication of a Tailored "Plug and Play" 3D Printed MIP-Based Straw for Scopolamine Removal in Alcoholic Beverages

Lara Fábia M. Oliveira ; Weida R. Silva ; João Flávio da Silveira Petruci

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The synthesis of molecularly imprinted polymers (MIPs) for scopolamine via bulk polymerization, combined with a 3D-printed device, aims to remove the drug from contaminated drinks, thereby preventing unwanted ingestion and potential crimes facilitated by the drug.

https://dx.doi.org/10.21577/0103-5053.20250149

Published online: September 17, 2025

 

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Review J. Braz. Chem. Soc. 2025, 36(11), e-20250110, 1-24

Koninginins and Related Octaketides from Trichoderma and Other Fungi: Chemical Diversity and Biological Activities

José C. I. Silva ; Felipe M. A. Silva ; Gilvan F. Silva ; Hector H. F. Koolen

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A comprehensive review of the chemistry and biological activities of koningins and related fungal octaketides.

https://dx.doi.org/10.21577/0103-5053.20250110

Published online: July 8, 2025

 

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Full Paper J. Braz. Chem. Soc. 2025, 36(11), e-20250107, 1-11

Energy, Fatty Acid, and Cytokine (TNF-α and IL-10) Content in Mature Human Milk: Comparison between Foremilk, Middle Milk, and Hindmilk Breastfeeding Intervals

Matheus C. Castro; Eloize S. Alves; Bruno H. F. Saqueti; Cintia Stefhany R. Ferreira; Joana M. V. Zacarias; Jeane E. L. Visentainer; Francieli S. O. Trombelli; Sueli M. T. Ichisato; Oscar O. Santos ; Jesui V. Visentainer

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Study of the energy content, fatty acid composition and cytokines tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) content in mature human milk at different breastfeeding intervals (foremilk, middle milk, and hindmilk).

https://dx.doi.org/10.21577/0103-5053.20250107

Published online: June 26, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250108, 1-15

Leishmania chagasi Dihydrofolate Reductase-Thymidylate Synthase Potential Inhibitors Identified by Virtual Screening

Luíza M. de Macêdo; Quezia V. F. S. da Fonseca; Iris C. dos Santos; Quézia L. S. Sampaio; Janine F. S. Silva; Moyses F. de Araujo Neto; Aníbal F. Santos Júnior ; Erika M. O. Ribeiro; Franco H. A. Leite; Humberto F. de Freitas ; Samuel S. R. Pita ; André L. B. Teles

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Flowchart summarizing the steps used to conduct virtual screening and identify potential selective inhibitors of Leishmania chagasi dihydrofolate reductase-thymidylate synthase (LcDHFR-TS).

https://dx.doi.org/10.21577/0103-5053.20250108

Published online: July 3, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250109, 1-9

Evaluation of Two Methods for Dyeing Alpaca Fibers Using Synozol Red K3BS and Novacron Navy FN-BN

Stamber A. Ramírez-Revilla ; Oscar A. Serrano Ollancaya ; Gustavo E. F. Vilcapaza Condori ; Derly D. Ortiz-Romero

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Application of ultrasound and conventional methods to alpaca fibers, demonstrating the absorption of the dyes Synozol Red K3BS and Novacron Navy FN-BN.

https://dx.doi.org/10.21577/0103-5053.20250109

Published online: July 4, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250111, 1-14

Determination of 13 Azithromycin Impurities in Pharmaceutical Formulations by HPLC-UV

Wellerson Wagner B. Silva ; Luiz Fernando S. Novaes ; Luiz Henrique C. Adriano ; Naiara Norberto T. de Oliveira ;
Wilson R. Braz ; Paula R. Chellini ; Marcone Augusto L. de Oliveira

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A method was developed and validated, by the application of 32 factorial, for the monitoring of azithomycin (AZM) and its impurities.

https://dx.doi.org/10.21577/0103-5053.20250111

Published online: July 11, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250113, 1-12

Platinum and other Metals Doped-Manganese Tungstate as a Novel Catalytic Support for NaBH4 Hydrolysis and Hydrogen Evolution Under Mild Conditions

Jorge Luiz dos Santos; Iterlandes Machado Junior; Gabriel Henrique Sperandio; Gessica do C. Dias; Anderson Dias;
Geraldo M. de Lima; Renata P. L. Moreira

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The platinum nanoparticles (Pt NPs)/MnWO4 composite was synthesized and showed to be an efficient, reusable catalyst for H2 generation via NaBH4 hydrolysis.

https://dx.doi.org/10.21577/0103-5053.20250113

Published online: July 15, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250114, 1-11

3D-Printed Liquid Handling Robot for the Development of Automated Analytical Methods

Aline D. Assunção ; Diogo M. de Jesus ; Teodoro R. Terra; Raquel G. Rocha ; José A. M. G. Costa; Luiz A. J. da Silva;
Guilherme L. Fernandes; Alessandro G. C. Dias; Rodrigo A. A. Muñoz ; Sidnei G. Silva ; Eduardo M. Richter

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A low-cost, 3D-printed liquid handling robot enables autonomous calibration, precise analytical management, and advanced flow analysis, integrating electrochemical and colorimetric detection for unprecedented automation.

https://dx.doi.org/10.21577/0103-5053.20250114

Published online: July 15, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250115, 1-13

Depolymerization of Lignin Using Bimetallic Gold/Palladium Functionalized TiO2 Catalyst

Charles-Oneil L. Crites ; José Carlos Netto-Ferreira; Geniece L. Hallett-Tapley; Samuel Banville; Luc Tremblay

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Lignin depolymerization was done using an Au/Pd@TiO2 via three subsequent reactions (alcohol oxidation, photo-cleavage and hydrogenolysis) under light irradiation (UV or green light).

https://dx.doi.org/10.21577/0103-5053.20250115

Published online: July 17, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250116, 1-12

A Comprehensive Multi-Method Approach to Investigating Simvastatin Forced Degradation:
Integrating in silico Evaluation with HRMS, NMR, and UV-HPLC

Paulo Roberto dos Santos ; Manuela Merlin ; Fávero R. Paula ; Sidnei Moura

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This study highlights the importance of combining in silico analysis with experimental techniques, emphasizing the need for careful handling of simvastatin, particularly concerning the formation of hydrolysis products, oxidation, and light exposure.

https://dx.doi.org/10.21577/0103-5053.20250116

Published online: July 18, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250118, 1-6

Chemical Compounds from Ocotea neesiana (Miq.) Kosterm Demolition Wood and Their Effect on the Growth of Xanthomonas citri subsp. citri

Jennifer A. O. Lima; Helena G. Ramos; Junior A. Chaves; Claudete C. do Nascimento; Luiz Henrique K. Queiroz-Junior;
Danielle F. da Silva; Jéssica Cristina Amaral; Maria Fátima das Graças F. da Silva ; Maria da Paz Lima

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Phytochemical study of Ocotea neesiana demolition wood led to the purification of eight compounds. The sesquiterpene α-cadinol and the diterpene 16-methylesteritol A exhibited antibacterial potential against Xanthomonas citri subsp. citri.

https://dx.doi.org/10.21577/0103-5053.20250118

Published online: July 22, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250119, 1-13

Enhancing the Transgene Performance of Polyethyleneimine through Amino Acid Conjugation

Laís T. de Marco; Fernando A. de Oliveira; Karine Panico; Anabella P. Rosso; Michelle Nascimento-Sales; Mariana M. R. Andrade; Marcelo A. Christoffolete; Lidiane Meier; Ismael C. Bellettini ; Fernando C. Giacomelli

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Amino acid-modified branched polyethyleneimines enable safer and more efficient deoxyribonucleic acid (DNA) delivery via polyplex formation, offering novel possibilities, including ocular gene therapy.

https://dx.doi.org/10.21577/0103-5053.20250119

Published online: July 23, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250120, 1-12

Production and Characterization of Bacterial Cellulose by Komagataeibacter hansenii UCP1619 Using the Fruit of Cereus jamacaru DC as an Alternative Medium

Amanda C. O. D. Barros ; Ivo D. L. Silva; Adriano N. Simões; José F. Q. Pereira ; Andréa M. S. S. Brito ; Glória M. Vinhas

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Representation of the bacterial cellulose (BC) production process using pulp juice from Cereus jamacaru DC fruit fermented with Komagataeibacter hansenii. The steps include the raw fruit, preparation of the medium, and the wet and dry forms of BC.

https://dx.doi.org/10.21577/0103-5053.20250120

Published online: July 24, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250121, 1-11

The Control of the Adsorption of Doxorubicin on Gold Surfaces Tracked by Surface-Enhanced Raman Scattering Spectroscopy

Pedro Victor A. Pessanha ; Antonio Carlos Sant'Ana

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Probing tailored interactions between doxorubicin and surface modified gold nanoparticles by surface-enhanced Raman scattering (SERS) spectroscopy.

https://dx.doi.org/10.21577/0103-5053.20250121

Published online: July 28, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250122, 1-15

Analysis of Emission Files Generated by a Global Model for Air Quality Simulation in the State of Rio de Janeiro

Thiago F. da Costa ; Otavio M. Sobrinho ; Amanda Karine C. Ribeiro ; Angie Natali Z. Ovalle ; Rizzieri Pedruzzi ;
Taciana T. A. Albuquerque ; Eduardo M. Martins

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Analysis of input files from Atmospheric Global Emission Inventory in the State of Rio de Janeiro.

https://dx.doi.org/10.21577/0103-5053.20250122

Published online: July 29, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250139, 1-11

Optimization of Methylene Blue Adsorption Using Hydrothermal Carbonization Chamaerops humilis-Derived Activated Carbon: A Response Surface Methodology Approach

Nouhaila Gadda ; Khalid Bouiti ; Najoua Labjar ; Youssra El Hamdouni ; Najoua Souad Lagmiri ; Hamid Nasrellah ;
Ayoub Cherrat ; Ghita Amine Benabdallah; Houda Labjar; Souad El Hajjaji

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Chamaerops humilis fruit pulp was hydrothermally carbonized and subsequently activated by H3PO4 to perform Methylene Blue adsorption using hydrochar-activated carbon (CHHAC). Material characterization (scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR)), adsorption experiments, and response surface methodology (RSM) modeling were carried out to optimize conditions, determine performance, and evaluate reusability.

https://dx.doi.org/10.21577/0103-5053.20250139

Published online: September 2, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250141, 1-11

Microwave Assisted Synthesis of Poly(Trimethylene Ether Glycol) with Novel ATR-FTIR Reaction Monitoring

Vinicius Kuchenbecker ; Cleverson Rogério Princival ; Edson Katekawa ; Wagner V. Magalhães ; Aparecido Junior de Menezes

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A novel polytrimethylene ether glycol (PO3G) oligomer microwave assisted synthesis with attenuated total reflectance Fourier transformed infrared (ATR-FTIR) reaction monitoring, moving forward into the green chemistry.

https://dx.doi.org/10.21577/0103-5053.20250141

Published online: September 9, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250142, 1-9

Strategic Innovation for Drug Enforcement: Brazilian Development of Certified Reference Material for Amphetamine Hydrochloride

Marília S. Souza ; Rodrigo G. Agostinho ; Mariana dos S. Dupim ; Rodrigo O. M. A. de Souza ; Karen C. C. Machado ;
Wagner Wollinger ; Eliane C. P. do Rego ; Fernanda G. Finelli

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This study developed a Brazilian amphetamine hydrochloride certified reference material to support forensic analyses, in partnership with the University, Institute of Metrology, Quality and Technology (Inmetro), and the Federal Police.

https://dx.doi.org/10.21577/0103-5053.20250142

Published online: September 12, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250143, 1-13

In silico Analysis of Soy Isoflavones and Their Metabolites in Prostate Cancer

Ayşenur Gök

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In silico analysis suggests that soy isoflavonoids such as 8-hydroxydaidzein and dihydrogenistein may inhibit androgen receptor signaling in prostate cancer, requiring further research.

https://dx.doi.org/10.21577/0103-5053.20250143

Published online: September 4, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250144, 1-14

High Content of Ascorbic Acid Obtained with Nonconventional Extractions of Lyophilized Camu-Camu (Myrciaria dubia) Fruit

Evelyn D. Pereira ; Daniel V. Cardoso ; Márcia R. Fagundes-Klen ; Carina C. Triques ; Ricardo F. Zara ; Jaqueline Hoscheid ; Erica Camila Pavan ; Edson A. da Silva

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Nonconventional extraction techniques, ultrasound-assisted and pressurized liquid extractions were compared to dynamic maceration, using ethanol as the solvent, to extract antioxidant compounds, especially ascorbic acid, from camu-camu fruits.

https://dx.doi.org/10.21577/0103-5053.20250144

Published online: September 8, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250146, 1-13

Production of Oosporein and Related Bibenzoquinone Analogues in Arcopilus amazonicus Revealed by Genome Mining and Mass Spectrometry Analysis

Moysés B. de Araújo Júnior ; Aline O. Santos ; Aline M. Rodrigues ; Thiago F. Sousa ; Felipe M. A. da Silva ;
Célio F. F. Angolini ; Renan S. Galaverna ; Lívia S. de Medeiros ; Fabiana E. Casarin ; Michel E. B. Yamagishi ;
Gilvan F. Silva ; Hector H. F. Koolen

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The integrated approach of genome mining with mass spectrometry sheds light on the biosynthesis pathway of oosporein (OOS) and analogous compounds in the culture of Arcopilus amazonicus.

https://dx.doi.org/10.21577/0103-5053.20250146

Published online: September 17, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250148, 1-19

In silico Identification of Lanostane Triterpenes as GluN1-GluN2B NMDA Receptor Inhibitors

Jonatas M. Negreiro ; José A. C. Oliveira ; Fátima M. Nunes ; Francisco G. Barbosa ; Jair Mafezoli ; Marcos C. Mattos ; Danielle S. Macedo ; Geancarlo Zanatta ; Maria C. F. Oliveira

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A multi-step in silico pipeline was used to screen 821 lanostane triterpenes against the N-methyl-D-aspartate (NMDA) receptor, identifying three lead candidates with high affinity and potential as fast-acting antidepressants.

https://dx.doi.org/10.21577/0103-5053.20250148

Published online: September 17, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250150, 1-17

Biomonitoring of Parabens in South Brazilian Urine Samples: A Validated SPE-LC-MS/MS Method

Cloé D. Loredo ; Giovana P. Peteffi; Camila F. de Souza; Roberta Z. Hahn; Ana Paula Grando; Giovanna S. Grassi; Marina V. Antunes; Rafael Linden

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A new method for determination of parabens in urine samples using solid phase extraction followed by liquid chromatography-tandem mass spectrometry (LC/MS-MS) analysis.

https://dx.doi.org/10.21577/0103-5053.20250150

Published online: September 19, 2025

 

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J. Braz. Chem. Soc. 2025, 36(11), e-20250151, 1-11

Luminescent Hybrids Based on Lanthanide Complexes Applied in Information Cryptography

Andreza A. de Souza ; Leonis L. da Luz ; Dayane K. D. N. Santos ; Dominique C. A. Dias ; Rodrigo J. de Oliveira ;
Severino Alves Júnior

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Eu3+-based hybrid responsive to chemical and physical stimuli under UV light as an alternative in the security area.

https://dx.doi.org/10.21577/0103-5053.20250151

Published online: September 22, 2025

 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

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