JBCS

19:27, Tue Dec 18

Open Access/APCs

The JBCS Office will be closed from Dec 22 to Jan 2

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(to be processed in the return on Jan 3, 2019)

Current Issue vol. 30, No. 1, 2019, p. 1-209

 

Several studies have reported the anticarcinogenic activity of conjugated linoleic acid (CLA) naturally found in the meat of ruminants (cattle, goats, and sheep) and in dairy products. The anticarcinogenic effect of the cis-9, trans-11 isomer of CLA was studied using two breast cancer (BC) cell lines, one positive (MCF-7) and the other negative (MDA-MB-231) for estrogen receptors. The nuclear magnetic resonance (NMR) metabolomics studies of intact BC cells demonstrate that CLA reduces the level of phosphocholine, a BC malignancy biomarker, in both cell lines. CLA also strongly interferes in acetone metabolism, mainly in the MCF-7 cell line, indicating an effect on fatty acid metabolism. Details are presented in the Communication Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy by Roberta M. Maria, Wanessa F. Altei, Napoleão F. Valadares, Richard C. Garratt, Adriano D. Andricopulo, Tiago Venâncio and Luiz A. Colnago on page 3.


Cover Article
J. Braz. Chem. Soc. 2019, 30(1), 3-7

Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy

Roberta M. Maria ; Wanessa F. Altei; Napoleão F. Valadares; Richard C. Garratt; Adriano D. Andricopulo; Tiago Venâncio; Luiz A. Colnago

How to cite this article

Several studies have reported the anticarcinogenic activity of conjugated linoleic acid (CLA) naturally found in the meat of ruminants (cattle, goats, and sheep) and in dairy products. The anticarcinogenic effect of the cis-9, trans-11 isomer of CLA was studied using two breast cancer (BC) cell lines, one positive (MCF-7) and the other negative (MDA-MB-231) for estrogen receptors. The nuclear magnetic resonance (NMR) metabolomics studies of intact BC cells demonstrate that CLA reduces the level of phosphocholine, a BC malignancy biomarker, in both cell lines. CLA also strongly interferes in acetone metabolism, mainly in the MCF-7 cell line, indicating an effect on fatty acid metabolism. Details are presented in the Communication Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy by Roberta M. Maria, Wanessa F. Altei, Napoleão F. Valadares, Richard C. Garratt, Adriano D. Andricopulo, Tiago Venâncio and Luiz A. Colnago on page 3.

http://dx.doi.org/10.21577/0103-5053.20180200

Published online: October 8, 2018

Editorial J. Braz. Chem. Soc. 2019, 30(1), 1-2

JBCS 30th Anniversary

Paulo Cezar Vieira

How to cite this article

 

http://dx.doi.org/10.21577/0103-5053.20180230


Communication J. Braz. Chem. Soc. 2019, 30(1), 3-7

Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy

Roberta M. Maria ; Wanessa F. Altei; Napoleão F. Valadares; Richard C. Garratt; Adriano D. Andricopulo; Tiago Venâncio; Luiz A. Colnago

How to cite this article

 

The effects of cis-9, trans-11 conjugated linoleic acid (CLA) on the metabolic profile of MCF-7 and MDA-MB-231 breast cancer cells were evaluated using high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy.

http://dx.doi.org/10.21577/0103-5053.20180200

Published online: October 8, 2018

Articles J. Braz. Chem. Soc. 2019, 30(1), 8-18

Synthesis and Cytotoxicity Evaluation of a Series of 3-Alkenyl-2-Hydroxy-1,4‑Naphthoquinones Obtained by an Efficient Knoevenagel Condensation

Cibelle C. David; Antonio C. S. Lins; Tania M. S. Silva; Júlia F. Campos; Teresinha G. Silva; Gardenia C. G. Militão; Celso A. Camara

How to cite this article

 

An efficient Knoevenagel condensation between aldehydes and lawsone was performed under new conditions showing good isolated yields in a short reaction time and simple conditions.

http://dx.doi.org/10.21577/0103-5053.20180146

Published online: July 31, 2018


J. Braz. Chem. Soc. 2019, 30(1), 19-32

Synthesis of Spiro-Pyrrolidinyloxindoles by Oxidative Rearrangement of N-Acyltetrahydro-β-carbolines Using an Oxone/Aqueous Acetone Mixture

Luisa L. Marçal; Simon J. Garden

How to cite this article

 

Substrate face controlled concerted oxidative rearrangement of N-acyltetrahydro-β-carbolines stereoselectively gives spiropyrrolidinyloxindoles.

http://dx.doi.org/10.21577/0103-5053.20180149

Published online: August 9, 2018


J. Braz. Chem. Soc. 2019, 30(1), 33-47

Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening

André L. P. G. Lourenço; Percilene F. Vegi; Jéssica V. Faria; Gustavo S. P. Pinto; Maurício S. dos Santos ; Plínio C. Sathler; Max S. Saito; Marcos Santana; Tatiana P. P. Dutra; Carlos R. Rodrigues; Robson Q. Monteiro; Alice M. R. Bernardino; Helena C. Castro

How to cite this article

 

Fourteen pyrazole compounds were synthesized and evaluated with regard to anticoagulant and antithrombotic activities. These derivatives were investigated through an integrated multiplex analysis virtual screening (IMA-VS) pipeline.

http://dx.doi.org/10.21577/0103-5053.20180150

Published online: August 9, 2018


J. Braz. Chem. Soc. 2019, 30(1), 48-59

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Caroline F. Grecco; Israel D. Souza; Vinicius R. Acquaro Junior; Maria E. C. Queiroz

How to cite this article

 

Determination of parabens in breast milk samples by dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS).

http://dx.doi.org/10.21577/0103-5053.20180151

Published online: August 10, 2018

J. Braz. Chem. Soc. 2019, 30(1), 60-70

Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC-ESI-TWIM-MS: a Comparison with GC-MS and GC × GC-QMS

Nayara A. dos Santos; Lilian V. Tose; Samantha R. C. da Silva; Michael Murgu; Ricardo M. Kuster; Rafael S. Ortiz; Flavio A. O. Camargo; Boniek G. Vaz; Valdemar Lacerda Jr. ; Wanderson Romão

How to cite this article

 

Analysis of cannabinoid standards by ultra performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UPLC-ESI-QTOF-MS) and UPLC-ESI-travelling wave ion mobility (TWIM)-MS.

http://dx.doi.org/10.21577/0103-5053.20180152

Published online: August 14, 2018


J. Braz. Chem. Soc. 2019, 30(1), 71-80

Occurrence of Pesticides and PPCPs in Surface and Drinking Water in Southern Brazil: Data on 4-Year Monitoring

Sergiane S. Caldas; Jean Lucas O. Arias ; Caroline Rombaldi; Lucas L. Mello; Maristela B. R. Cerqueira; Ayrton F. Martins; Ednei G. Primel

How to cite this article

 

Fifty-one compounds including PPCPs and pesticides were monitored from 2011 to 2014 in drinking and surface waters in Rio Grande do Sul State.

http://dx.doi.org/10.21577/0103-5053.20180154

Published online: August 15, 2018


J. Braz. Chem. Soc. 2019, 30(1), 81-89

Synthesis, Photophysical and Electrochemical Properties of Novel D-π-D and D-π-A Triphenylamino-Chalcones and β-Arylchalcones

Rafaela G. M. da Costa; Francisco R. L. Farias; Luis Maqueira; Carlos Castanho Neto; Leonardo S. A. Carneiro; Joseany M. S. Almeida; Camilla D. Buarque; Ricardo Q. Aucélio; Jones Limberger

How to cite this article

 

A series of triphenylamino (TPA)-chalcones and β-arylchalcones, displaying either D-π-D or D-π-A architecture, were synthesized and characterized. Photophysical and electrochemical properties of these compounds were evaluated.

http://dx.doi.org/10.21577/0103-5053.20180156

Published online: August 17, 2018


J. Braz. Chem. Soc. 2019, 30(1), 90-96

Influence of Copper and Metallic Alloys on the Oxidation Reaction of Commercial Biodiesel in Mixture with Natural Antioxidant

Letícia T. Chendynski; Érica S. Romagnoli; Ana Carolina G. Mantovani; Marissa Kimura; Leonardo C. Marques; Dionisio Borsato

How to cite this article

 

Influence of copper and metallic alloys on the biodiesel oxidation reaction.

http://dx.doi.org/10.21577/0103-5053.20180157

Published online: August 17, 2018

J. Braz. Chem. Soc. 2019, 30(1), 97-107

Synthesis of 1,2,3-Triazole Derivatives of 4,4'-Dihydroxybenzophenone and Evaluation of Their Elastase Inhibitory Activity

Maria C. F. Dias; Thiago Q. Gularte; Róbson R. Teixeira ; Jorge A. N. Santos; Eduardo J. Pilau ; Tiago A. O. Mendes; Antônio J. Demuner; Marcelo H. dos Santos

How to cite this article

 

The conversion of 4,4'-dihydroxybenzophenone into a series of 1,2,3-triazolic derivatives resulted in the identification of bis(4-(1-(4-iodobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)benzophenone with significant elastase inhibitory activity (IC50 = 16.6 ± 1.9 µM, inhibition constant (Ki) of 11.12 µM).

http://dx.doi.org/10.21577/0103-5053.20180158

Published online: August 20, 2018


J. Braz. Chem. Soc. 2019, 30(1), 108-115

In vitro Evaluation of Ca, Cu, and Mg Bioaccessibility in Fresh and Dried Fruits

Thais T. Mingroni; Juliana Hamada; Alexsandra D. S. Xavier; Cleusa Cavalcante; Angerson N. do Nascimento

How to cite this article

 

An in vitro evaluation of Ca, Cu, and Mg bioaccessibility in fresh and dried fruits was carried out, with results demonstrating that the dehydration process negatively affects bioaccessibility of Ca and Mg in dried fruits.

http://dx.doi.org/10.21577/0103-5053.20180159

Published online: August 20, 2018

J. Braz. Chem. Soc. 2019, 30(1), 116-123

Anti-Parasite Activity of Novel 3,5-Diiodophenethyl-benzamides

Manuel Pastrana Restrepo ; Verónica Surmay Surmay; Elkin Galeano Jaramillo; Sara Robledo Restrepo

How to cite this article

 

Novel 3,5-diiodophenethyl-benzamides as new lead compounds for the development of new anti-parasites treatment.

http://dx.doi.org/10.21577/0103-5053.20180160

Published online: August 20, 2018


J. Braz. Chem. Soc. 2019, 30(1), 124-131

Eco-Friendly Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by FeCl3/Al2O3 and Analysis of Large 1H NMR Diastereotopic Effect

Isabel Monreal; Mariano Sánchez-Castellanos; Karla Ramírez‑Gualito; Gabriel Cuevas; Karla A. Espinoza; Ignacio A. Rivero

How to cite this article

 

The quinazolinones showed a large range diastereotopic effect that was studied through nuclear magnetic resonance (NMR) and computational calculations.

http://dx.doi.org/10.21577/0103-5053.20180161

Published online: August 21, 2018


J. Braz. Chem. Soc. 2019, 30(1), 132-139

Ultrasonic Extracts of Morinda citrifolia L.: Characterization of Volatile Compounds by Gas Chromatography-Mass Spectrometry

Daiane B. M. Lima; Anaí L. dos Santos; Ariel O. Celestino; Nayna Sampaio; Jéssica Baldez; Maria I. S. Melecchi; Thiago R. Bjerk; Laíza C. Krause; Elina B. Caramão

How to cite this article

 

Sonication extraction from leaves and fruits using response surface methodology and analysis of the extracts by gas chromatography-mass spectrometry (GC-MS) showing as major compounds: octanoic acid, vitamin E, phytol and hydroxymethylfurfural.

http://dx.doi.org/10.21577/0103-5053.20180162

Published online: August 22, 2018


J. Braz. Chem. Soc. 2019, 30(1), 140-148

Sample Preparation Applied to Analysis of Proteins in Cowpea Seeds (Vigna unguiculata (L.) Walp.)

Thábata L. A. B. Nascimento; Tiago L. S. Coelho; Cícero A. Lopes Júnior; Samuel A. A. Sousa; Herbert S. Barbosa

How to cite this article

 

Optimization of sample preparation procedure in the extraction of cowpea proteins using the high-performance liquid chromatography (HPLC) technique as a comparative tool.

http://dx.doi.org/10.21577/0103-5053.20180163

Published online: August 22, 2018

J. Braz. Chem. Soc. 2019, 30(1), 149-157

Biotechnological Properties of Sponges from Northeast Brazil: Cliona varians as a Biocatalyst for Enantioselective Reduction of Carbonyl Compounds

Valéria B. Riatto ; Mauricio M. Victor; Jaqueline F. Sousa; Carla Menegola

How to cite this article

 

This work describes the first use of marine sponge Cliona varians as biocatalytic agents in the stereoselective reduction of α-keto esters and isatin.

http://dx.doi.org/10.21577/0103-5053.20180165

Published online: August 27, 2018


J. Braz. Chem. Soc. 2019, 30(1), 158-163

Male-Specific Volatiles Released by the Big Avocado Seed Weevil Heilipus lauri Boheman (Coleoptera: Curculionidae)

Alicia A. Romero-Frías ; Diana C. Sinuco; José Maurício S. Bento

How to cite this article

 

Volatile organic compounds released by Heilipus lauri (Coleoptera: Curculionidae).

http://dx.doi.org/10.21577/0103-5053.20180166

Published online: August 28, 2018

J. Braz. Chem. Soc. 2019, 30(1), 164-172

Synthesis, Antimicrobial Activity and Structure-Activity Relationship of Some 5-Arylidene-thiazolidine-2,4-dione Derivatives

Raíssa K. C. de Paiva; Jamerson F. da Silva; Hudieyllen A. Moreira; Osvaldo G. Pinto; Lilian T. F. M. Camargo; Plínio L. F. Naves; Ademir J. Camargo; Luciano Ribeiro; Luciana M. Ramos

How to cite this article

 

The synthesis and antimicrobial activity of thiazolidine-2,4-dione derivatives are described. The structures of the synthesized compounds were confirmed by infrared and nuclear magnetic resonance. All compounds were evaluated for their in vitro antibacterial activity. Density functional theory and principal component analysis were used to discriminate the compounds.

http://dx.doi.org/10.21577/0103-5053.20180167

Published online: August 28, 2018


J. Braz. Chem. Soc. 2019, 30(1), 173-179

On the Use of an Interpolation Approach for the Choice of Gaussian Polarization Functions

Fernando Ratuchne; Ana C. Mora; Ricardo Celeste; Albérico B. F. da Silva

How to cite this article

 

The polarization exponents (αw) vary with the atomic number (Z) for a sequence of atoms in a row with the same valence structure. Thus, αw can be obtained by interpolation.

http://dx.doi.org/10.21577/0103-5053.20180168

Published online: August 30, 2018

J. Braz. Chem. Soc. 2019, 30(1), 180-187

Use of Coconut Charcoal and Menthone-Thiosemicarbazone Polymer as Solid Phase Materials for the Determination of N,N-Dimethyltryptamine, Harmine, Harmaline, Harmalol, and Tetrahydroharmine in Ayahuasca Beverage by Liquid Chromatography-Tandem Mass Spectrometry

Sandro Navickiene ; Luis F. S. Santos; Mônica C. Santos; Alain Gaujac

How to cite this article

 

Evaluation of efficiency of coconut charcoal and menthone-thiosemicarbazone as alternative solid phase extraction adsorbent for the determination of alkaloids in ayahuasca beverage.

http://dx.doi.org/10.21577/0103-5053.20180169

Published online: August 30, 2018


Short Report J. Braz. Chem. Soc. 2019, 30(1), 188-197

Synthesis, in silico Study and Antimicrobial Evaluation of New Selenoglycolicamides

Helivaldo D. S. Souza; Roxana P. F. de Sousa; Bruno F. Lira; Raquel F. Vilela; Nathalie H. P. B. Borges; José P. de Siqueira‑Junior; Edeltrudes O. Lima; Jeane U. G. Jardim; Gracielle A. T. da Silva; José M. Barbosa‑Filho; Petrônio F. de Athayde‑Filho

How to cite this article

 

The organoselenium compounds presented are prominent in medicinal chemistry; due to the increase of resistant fungi and bacteria, novel organoselenium compounds have been investigated as potent antimicrobials.

http://dx.doi.org/10.21577/0103-5053.20180148

Published online: August 6, 2018


J. Braz. Chem. Soc. 2019, 30(1), 198-209

A Facile Synthesis of Novel Isatinspirooxazine Derivatives and Potential in vitro Anti-Proliferative Activity

Iara S. Santos; Fabiana S. Guerra; Lucas F. Bernardino; Patrícia D. Fernandes; Lidilhone Hamerski; Bárbara V. Silva

How to cite this article

 

It was synthesized a new isatinspirooxazine derivative with an half maximal inhibitory concentration (IC50) = 0.34 µM, more potent than the reference drug, doxorubicin (IC50 = 1.88 µM), in breast cancer line MDA-MB231.

http://dx.doi.org/10.21577/0103-5053.20180153

Published online: August 15, 2018

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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