JBCS

Keywords map of the most frequently encountered terms in articles regarding the use of silver nanoparticles as antimicrobial agents between 2014 and 2023.

Localized protein frustration is higher around druggable hotspots, partially explaining their origin and suggesting innovative hit-to-lead strategies.

How much PROTACs (protheolysis targeting chimeras) can change the drug discovery? Since its discovery in 2001, a huge evolution has been done in terms of mechanisms, proof of concepts and design. A new PROTAC drug can be one step from the market, with ARV-471 that just entered in phase III clinical trials.

Relationship between drug repositioning, artificial intelligence with essential participation of human beings, generating molecules which could turn into medicines.

Cannabidiol (CBD) and its synthetic derivatives and analogues have been investigated for decades due to their medicinal uses as neuroprotective, anti-convulsive, antinociceptive, and anti-inflammatory, aimed at clarifying the mechanisms of action underlying their pharmacology and contribute to the development of innovative drugs.

Ionic silsesquioxanes, silica based hybrid polymers with amazing properties, which play important roles in the architecture of multifunctional nanostructured materials to be applied in priority areas such as health, food, and sustainable energy.

Chromatographic techniques and alternative strategies for qualitative and quantitative analysis of cannabinoids in medicinal cannabis products and cannabis extracts.

Evolution of molecular simulations applications in drug-discovery in the past 30 years.

This review presents the main developments in inhibitors of cruzipain/cruzain, a crucial enzyme in the life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease, from the 1990s to the present.

Workflow diagram of a structure-based virtual screening (SBVS) process showing the two approaches discussed in this work.

This work reviews protein kinase inhibitors of the last 30 years and highlights contributions from Brazilian researchers.

The advancements in both chemistry and the biological behavior, with a focus on boron neutron capture therapy involving specific polyhedral boron clusters, are examined.

Metallocenes, "half sandwich" M-arenes and metal carbonyls are potential drugs against malaria and neglected diseases caused by trypanosomatid parasites and parasitic helminths.

The image shows the evolution in the usage of Computer-Assisted Drug Design (CADD) methods during the last 30 years.

A bibliographical review of molecular dynamics enhanced sampling techniques for analysis of Plasmodium falciparum proteins and their implications for antibody binding.

This article reviews the synthesis and biological activities of the amino-quinazoline privileged structure over the last 30 years, focusing on the last decade.

Enhancing the equilibrium between promiscuous and privileged structures in Medicinal Chemistry.

Lead-free halide double perovskites have gained importance due to their promising optoelectronic properties and the possibility of forming multiple combinations, which increases their range of applications.

Piperine is a natural amide with an interesting chemical structure and promising activities against several parasitic diseases. It is a renewable natural product easily extracted from black pepper, one of the most important spices used worldwide.

Synthesis of pure, doped and core@shell oxide nanoparticles through a metalorganic layer-by-layer deposition method applied to porous host matrices, where the fine size control allows property tuning.

The ubiquitous non-zero electric potentials in our world profoundly impact their properties, producing unexpected chemical reactions and other surprising phenomena. So, when and where does the electroneutrality principle which "expresses the fact that all pure substances carry a net charge of zero" actually apply?

A bibliometric analysis was performed to map the research performed in Brazil on multicomponent reactions over a period of 30 years through a literature search.

Nitroaromatic as drug: Food and Drug Administration (FDA) approval, mechanisms of bioactivation, metabolism and toxicity, and synthesis of nitroaromatic fragment by nitration and amine oxidation.

The image depicts the possible applications of the nanofibers that could involve energy storage and conversion, environmental remediation, and catalysis.

This account describes the LASSBio Chemical Library diversity and a virtual screening against feline McDonough sarcoma-like tyrosine kinase 3 (FLT3).

In this short review, we present how carbamates can be seen as "good guys" by their use in medicine (hope), or "bad guys", due to their misuse in pesticides and as chemical weapons (death).

Modified flavonoids were synthesized and showed potent antiproliferative and antiparasitic activity in vitro and in vivo, and antiviral activity in vitro.

Mini review highlighting amidine derivatives: principal synthesis methods and anti-Leishmania activity results.

This critical review encompasses the analysis of studies from 2016 to 2023 that employ the Community Multiscale Air Quality Model (CMAQ) model for ozone simulation.

Mangroves are highly productive ecosystems distributed in tropical and subtropical regions in the world. Many different species of fungi can be isolated from this ecosystem. These fungi can be a rich source of useful antimicrobial compounds.

Spectroscopic, chemical and biological data published between 1965-2022 on acylphloroglucinol derivatives are compiled in this review.

The occurrence of antibiotics in the Brazilian aqueous matrix was carefully revised. The publication of 24 articles on this occurrence revealed the detection of 23 antibiotics in 5 aquatic matrices, ranging from 0.13 to 37300 ng L⁻¹.

The cave ecosystem hosts a high diversity of microorganisms with complex strategies to survive in limited environmental conditions. Here, we highlight the biology and chemistry of cave microbiomes with multi-omics perspectives.

We discuss the use of biochars and hydrochars in electrodes applied in the electrochemical sensing and degradation of target compounds.

This review presents the principal aspects of the drug discovery process targeting breast cancer and highlights the most promising derivatives of caged xanthones and thiosemicarbazones explored in conventional therapy. Also, it presents details of photodynamic therapy and the action of photosensitizers as an alternative therapy for breast cancer.

Scientific writing from first words to publication, as well as its challenges, including ethical aspects, are presented and discussed in this opinion manuscript.

Two-dimensional liquid chromatography (2D-LC) for multiple applications.

Medicine has been improving the assessment of health-related biomarkers towards precise diagnosis. In this context, we discuss how capillary electromigration techniques stand out as an alternative for the development of new high-efficient cost-effective diagnostic assays.

A general overview on synthetic developments on stereoselective methodologies for Strecker, Mannich, Passerini and Ugi reactions are hereby presented.

Biogenic silver nanoparticles are synthesized through silver(I) reduction promoted by biomolecules. The one-pot biosynthetic process leads to stable silver nanoparticle (AgNP) colloids with surfaces capped by some of the biomolecules that also took part in their synthesis.

Computational chemistry is a valuable tool for understanding reaction mechanisms and supporting experiments in several areas, such as organic synthesis, natural products (and biochemical transformations), and systems of environmental interest.

Graphically representation of quantum dots (QDs) coated molecular imprinted polymer sensor for the determination of emerging and classical pollutants. Nanoscale QD materials are suitable for fluorescence analysis. The modification with quantum dots provides many advantages such as rapid detection, highly selective and easily operational.

The review highlights the different studies on marine natural products with antiviral and larvicidal activity against Dengue, Zika and Chikungunya and their main vector Aedes aegypti.

Workflow of gas chromatography coupled to mass spectrometry-based metabolomics analysis of damage skin.

The production, chemical composition and potential applications of fusel oil were demonstrated.

The circular economy and circular chemistry play an important role in the challenges and issues related to sustainability.

Biosurfactants are molecules of animal, vegetable and microbial origin with various industrial applications. Animal and plant biosurfactants are obtained by extractive methods. Microbial biosurfactants are extracelular metabolites and can be obtained by fermentation processes in the biorefineries contexts.

Green is the color of the future.

Internet of things (IoT) can play key role to attend the sustainable development goals. The association of IoT with analytical chemistry enables the real-time analytes monitoring, that assess impacts of human activities on environmental and human health.

This review provides basic theory of time domain nuclear magnetic resonance (TD-NMR) relaxometry of paramagnetic cations in solution and important applications in electrochemistry, analytical and inorganic chemistry.

This review intends to show how the challenges for the production of some low molecular weight drugs produced by synthetic routes that involve at least one biotechnological step using microorganisms or enzymes were faced.

In this review, we present an overview of the uses of hydrogen and its importance to a sustainable society.

The solvents derived from renewable raw materials can be used as an alternative green media for palladium-catalyzed carbonylation reactions, offering a promising and alternative way to construct a wide array of organic molecules carrying a carbon-oxygen double bond.

In this review contribution we discuss the use of sulfonic acid-functionalized task-specific ionic liquids as sustainable and reusable catalysts for multicomponent reactions applied to the synthesis of heterocycles and related compounds.

A systematic review analyzing 196 studies from 16 territorials in Latin America with information about the current state of knowledge regarding the abundance, distribution, and associated impact of microplastics in different matrices was performed.

Amino acid-based deep eutectic solvents (DES) as a greener methodology for biomass fractionation and sugars chemical conversion to high value-added compounds.

In this review, the methods for the production of selenium-quinones and tellurium-quinones and their biological applications until 2021 are highlighted.

Iron ore tailings (IOT) are mainly composed of iron oxides, silica, and other minerals such as kaolinite. The IOT can be used for different applications related to the civil construction and a variety of technological applications.

The interfacial electron transfer reactions that take place in dye-sensitized TiO₂ molecular devices for solar energy conversion govern their efficiency. This review visits general aspects of these reactions.

This review provides an overview and update regarding the use of some nanomaterials as biosensors, which have shown attractive results over the last few years.

This review highlights the increase in the number of absolute configuration reassignments of natural products over the last decade and describes the main approaches used both in the original incorrect assignments and stereochemical corrections. It also provides the readers with critical information for the choice of appropriate methods for unambiguous stereochemical determination.

Worldwide use and advances in biodiesel research over the past 15 years are reported in this review.

A C-H activation process represents one of the most advanced tool in the field of organic synthesis nowadays, and it requires knowledge that should be studied and learned. Therefore, carrying out a C-H activation reaction in the right direction, following the right steps, can improve its performance and guarantee plausible results.

Several calibration strategies have been reported in the literature over the last few years to improve quantitative analysis using laser-induced breakdown spectroscopy (LIBS).

This review manly focusses on development of energy conversion devices, such as dye-sensitized solar cells, solar fuels, photosensors and light-emitting devices by outlining investigations carried out at the Laboratory of Photochemistry and Energy Conversion (LFCE) in the University of São Paulo, including researches that led to technological innovation.

This review discusses colloidal aspects of crude oil asphaltenes and their impact on oil production issues.

We review semiconductor photocatalysts for the H₂ evolution reaction that have displayed the best reported activities and quantum efficiencies.

The serpentine is a versatile mineral family rich in Mg silicate with several polymorphic phases with unique physicochemical properties and potential applications.

In this review we present the state of the art of (bio)conjugation strategies applied to semiconductor quantum dots for biomedical / bioanalytical purposes.

The aim of this review is to provide insight into porphyrin chemistry research in Brazilian institutions, especially that involving catalytic purposes, and discuss some advances achieved in the topic with the collaboration of researchers from the Universidade de Aveiro, Portugal.

The symbiotic relation between vibrational spectroscopy and chemometrics in forensic chemistry contexts.

Representation of a Raman imaging experiment: the spectral array of data and the univariate/multivariate data treatment for the generation of chemical images.

This review celebrates the centenary of chemical investigations on Aspergillus niger. Structurally diverse secondary metabolites produced by this fungus, besides its potential on selective biotransformation of terpenes, are presented.

Magneto-responsive hydrogels are important platforms for biomedical applications, such as drug delivery, tissue engineering and cancer therapy, and for environmental applications.

Formation and biological effects of deoxyribonucleic acid (DNA) adducts from endogenous and exogenous aldehydes.

Illustration of the cross section of an oil pipeline showing the scale formed by sweet corrosion.

Capsaicin, piperine, gingerol and other pungent natural compounds are technologically developed bioproducts for civilian's self-defense proposes.

Natural deep eutectic solvents (NADES) comprise a new family of agro-based, eco-friendly reaction media that can replace traditional organic solvents in polymerization and polymer reactions. A review of the current progress in this exciting new field is given in this article.

This review on the RM1 model presents improvements to the methodology as well as a wide range of its applications to theoretical, organic, physical, analytical, and inorganic chemistry, along with their interfaces with medicine, biology, and materials science.

Concise syntheses of bis-Strychnos alkaloids (-)-sungucine, (-)-isosungucine, and (-)-strychnogucine B have been accomplished from (-)-strychnine. Computational chemistry was employed to rationalize the regiochemical course of key transformations therein.

Typical water-based oil sands extraction process in northern Alberta, Canada and macroscopic schematic for settling tests on mature fine tailings (MFT) after treatment with polymer flocculants.