JBCS

This work describes the synthesis of a novel isatin-type 5'-(4-alkyl/aryl-1H-1,2,3-triazoles) series whose derivatives are promising candidates for the treatment of different illnesses, including cancer and neglected diseases, among others.

The anti-asthmatic compound CMI-977 (LDP-977) was prepared in 9 steps from p-fluorophenol. The key steps involve a Mukaiyama oxidative cyclization, which provides the trans-THF unit, and a Seyferth-Gilbert homologation to construct the triple bond in the target molecule.

Nanoparticles are introduced in many materials composition to enhance its performance. Poly-lactic acid enclosing gold nanoparticles (AuNP), superparamgnetic iron oxide nanoparticles (SPION) and SPION@AuNP presented in this work are examples of materials with synergistic properties

3D QSAR models with high internal and external consistency and predictive power were integrated with molecular docking and molecular dynamics to provide insights into the structural basis for selective inhibition of the Trypanosoma brucei aldolase enzyme.

Safe, recyclable, easily handleable and inexpensive tribromo- and trichloroisocyanuric acids react with cinnamic acids in NaOH/H₂O/Et₂O at room temperature to produce (E)-2-halostyrenes regioselectively in 25-95% yield, through an electrophilic mechanism.

This novel benzoquinoxaline exists as the enol-imine rather than the keto-amine tautomer in the solid state and in solution. DFT calculations on the tautomers of related compounds showed that the relative stabilities are dominated by the degree of aromaticity or solvation effects.

The phytochemical study of flowers and green fruits of Senna spectabilis has furnished a new 2,6-dialkylpiperidin-3-ol alkaloid, named (-)-7-hydroxycassine, along with five known chemical constituents β-sitosterol, luteolin, 3-methoxyluteolin, betulinic acid and trans-cinnamic acid, that are being reported for the first time in this species.

Theoretical tools were used to study spectroscopic properties of the conjugate Microcystin-LR-europium cryptate. The theoretical quantum yield of luminescence (23%) suggests this luminescent system as an excellent conjugate to be used in the ELISA assay for detection by luminescence of the Microcystin-LR in water.

The added-salt dependent growth of sodium lauryl ether sulfate (SLES) micelles, determined by time-resolved fluorescence quenching, is distinct from that of sodium alkyl sulfate micelles, consistent with a larger headgroup size of SLES.

The present work presents the vertical distributions of the metals Al, Cu, Co, Cr, Fe, Mn, Ni, Pb and Zn in two sediment cores from the Macela Reservoir, located in Sergipe State in Northeast Brazil.

Simple anionic nucleophiles react with alkoxysilanes in the gas-phase by formation of a hypervalent siliconate species that can undergo further elimination by different channels leading to the formation of carbanions or siloxide-type anions.

A new hybrid material based on biogenic silver nanoparticles strongly adsorbed in layered double hydroxides (LDHs) exhibited antimicrobial activity and no cytotoxic effect on fibroblast cell cultures demonstrating to be an interesting nanobiocomposite for biomedical and cosmetic applications.

Particles can be lifted in electric fields. It is shown that the lifting of charged hydrophobic particles is consistent with a model for insulating particles, but the lifting of hydrophilic particles is consistent with a model for insulating particles at low humidity and a model for conducting particles at high humidity.

SEM (scanning electron microscopy) images of Bi₂S₃ prepared by refluxing (a-b) and sonochemical methods (c-d) show that in both cases flower-like superstructures are formed. Sonochemical method yields these flower-like superstructures with better morphological homogeneity.

An advance in the magnetic control of bioelectrochemical reactions, by construction of a system containing simultaneously a magnetic particle (for controlled driving), an enzyme (for biocatalysis) and a redox mediator (for mediation of electron transfer) is reported.

The graphical abstract shows that mixing cellulose pulp with a solvent composed by NaOH/H₂O and some additives such as surfactant molecules and/or salts it is possible to obtain a nice and clear solution without undissolved material as seen by the inserted optical micrograph.

The hydrogel absorbs and retains a huge amount of water. When applied to soil it increases the water-holding and/or nutrient retention capacity, and improves plant growth. An efficient use of water is promoted contributing to water sustainability.

Used frying oil has produced biobased resins, which were successfully employed as binder in printing ink (offset or typographic printers) formulations.

2D Hetero-spectral ¹³C nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) (ΔB = 80 mT, g ca. 2, s derivative mode) correlation spectrum of the studied mined and natural soil samples. The data suggest uronic acid interacting with the hard acid metal ion VO²⁺, and not cathecol or salicylic acid structures as is pointed normally for the complexation of hard acid metal ion with natural organic matter (NOM).

Safrole Oxide (SO) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microparticles were obtained using solution enhanced dispersion by supercritical fluid (SEDS). Different shapes were observed for coprecipitated SO/PHBV, and were dependent on the experimental-processing conditions.

This work describes an approach to the growth of lead sulfide (PbS) micro and nanocrystals in poly(acrylic acid) (PAA) ultrathin film. The morphology of the composite formed can be adjusted by controlling the Pb²⁺ and thioacetamide (TAA) concentrations and the pH value of the TAA solution.

During the preparation of the activated carbon-supported magnetite from coconut shells, iron nitrate fills the pores where it is converted to hematite upon heating under air flow. At 450 ºC, carbon monoxide is produced and then reduces the hematite to produce magnetite particles with a hematite core.

Babassu nuts, Orbignya phalerata Martius (Arecaceae), were collected from different regions of Maranhão State, Brazil. The extracted babassu oils were analyzed by gas chromatography-mass spectrometry (GC-MS) after derivatization and the relative composition of the fatty acids was used to perform a discriminating analysis of the biodiversity of O. phalerata from Maranhão.