The beginning: global responsibility in healthcare - with a focus on tropical disease
Special Issue Neglected and Rare Diseases
André S. de Oliveira; Milene L. da Silva; Ana Flávia C. S. Oliveira; Cynthia C. da Silva; Róbson R. Teixeira; Sérgio O. De PaulaHow to cite this article
Dengue virus enzymes are important targets for antiviral drug design.
Fábio R. Oliveira; Mariely C. Pessoa; Rosyana F. V. Albuquerque; Taysa R. Schalcher; Marta C. MonteiroHow to cite this article
This review summarizes the chemical structure of dapsone, a drug used mainly in the treatment of leprosy and dermatitis, and its metabolism leads to the formation of toxic metabolites that cause adverse reactions, such as methemoglobinemia, which occurs because of the inability of methemoglobin to bind oxygen, causing a state of functional anemia.
Eufrânio N. da Silva Júnior; Guilherme A. M. Jardim; Rubem F. S. Menna-Barreto; Solange L. de CastroHow to cite this article
The present review describes the synthesis of naphthoquinoidal compounds and their derivatives, their activities and mechanisms of action against Trypanosoma cruzi, the causative agent of Chagas disease.
Marcelo G. Lorenzo; Diogo M. Vidal; Paulo H. G. ZarbinHow to cite this article
The present review describes avenues recently explored for the search of behavior modifying compounds by means of high throughput methodologies. Specifically, examples of how such methodologies mediate the search for new repellents and attractants are described.
Izaltina Silva-Jardim; Otavio H. Thiemann; Fernanda F. AnibalHow to cite this article
The main form of treatment for leishmaniasis and Chagas disease is still chemotherapy. There is no effective vaccine available and the search for new drugs is a priority. This review outlines the current understanding of different drugs against leishmaniasis and Chagas disease and the search for new drugs.
Mirela F. Rabito; Mariana B. Almeida; Amanda L. Moreira; Amadeu H. Iglesias; Fernando de Paula; Bruna P. da Silva; Diógenes A. Cortez; Suzana L. Nixdorf; Izabel C. P. FerreiraHow to cite this article
This study aimed to develop and validate a liquid cromatographic method for simultaneous determination of two sesquiterpene lactones from Tanacetum parthenium. A potencial tool for quality control of this medicinal plant with in vitro and in vivo antileishmaniasis activities.
Lorena R. F. de Sousa; Suelem D. Ramalho; João B. Fernandes; Maria Fátima das G. F. da Silva; Mônica R. da C. Iemma; Caroindes J. Corrêa; Dulce H. F. de Souza; Maria I. S. Lima; Paulo C. VieiraHow to cite this article
Leishmanicidal galloylquinic acids from B. coccolobifolia showed as novel noncompetitive and mixed inhibitors of arginase from L. amazonensis.
Aline Coqueiro; Luis O. Regasini; Gabriel M. Leme; Luciana Polese; Camila T. Nogueira; Mayara L. Del Cistia; Marcia A. S. Graminha; Vanderlan da S. BolzaniHow to cite this article
Chemical composition of the hexane fractions from the leaves and branches of B. glaziovii that exhibited activity in the leishmanicidal tests as evaluated by high-resolution gas chromatography (HRGC) and GC- MS.
Carolina G. Oliveira; Pedro Ivo da S. Maia; Marcelo Miyata; Fernando R. Pavan; Clarice Q. F. Leite; Eduardo Tonon de Almeida; Victor M. DeflonHow to cite this article
CoIII complexes with a family of thiosemicarbazones were evaluated for their anti-Mycobacterium tuberculosis effect. Complex 5 exhibited good activity with high selectivity index.
Maíra Magalhães Trintinalia; Atecla Nunciata Lopes Alves; Liliam Fernandes; Etelvino Jose Henriques Bechara; Nilson Antonio AssunçãoHow to cite this article
HPLC profile of three amino acids representative of the biochemical alterations found in maple syrup rinue disease, a metabolic disorder.
Ricardo A. P. Pádua; Giovani P. Tomaleri; Renata A. G. Reis; Juliana S. David; Valeria C. Silva; Matheus P. Pinheiro; Maria Cristina NonatoHow to cite this article
Monitoring of flavin mononucleotide fluorescence when exposed to solvent upon protein unfolding was used to determine flavoprotein melting temperature (Tm). Interaction of ligands to flavoproteins induces a shift in Tm and this phenomenon can be used on the screening of compounds as a tool for hit identification during the process of drug development.
Getúlio G. Junqueira; Marcelo R. Carvalho; Peterson de Andrade; Carla D. Lopes; Zumira A. Carneiro; Renata Sesti-Costa; João S. Silva; Ivone CarvalhoHow to cite this article
Synthesis of galactose-containing triazol-arylsulfonamides and evaluation of Trypanosoma cruzi trans-sialidase inhibition, antitrypanosomal and cytotoxicity activities.
Gabriela B. Santos; Marília O. Almeida; Iara A. Cardoso; Viviane Manfrim; Fernanda O. Chagas; Juliano S. Toledo; Camila C. Pinzan; Alexandre Suman de Araujo; Angela K. Cruz; Monica T. Pupo; Flavio S. EmeryHow to cite this article
Preliminary evaluation demonstrated high leishmanicidal activity for aphidicolin and a new oxime derivative with selectivity for the L. braziliensis species.
Marcos Pivatto; Luciene R. Baccini; Abhinay Sharma; Myna Nakabashi; Amanda Danuello; Claudio Viegas Júnior; Celia R. S. Garcia; Vanderlan S. BolzaniHow to cite this article
Piperidine alkaloids (-)-cassine and (-)-spectaline isolated from the flowers of Senna spectabilids and semisynthetic derivatives (-)-3-O-acetylcassine and (-)-3-O-acetylspectaline were assessed for their antimalarial inhibitory activity by means of flow cytometry screening assay.
Mônica F. Z. J. Amaral; Daniel R. Callejon; Thalita B. Riul; Marcelo D. Baruffi; Fabiano T. Toledo; Norberto P. Lopes; Giuliano C. ClososkiHow to cite this article
Thiophene derivatives obtained by Negishi reaction induced cell death on Leishmania braziliensis without inducing toxicity on macrophage.
Fernanda B. Scalco; Maria Lúcia C. Oliveira; Ruth E. Simoni; Francisco R. Aquino NetoHow to cite this article
The survey presents the results obtained after diagnostic investigation of inborn errors of metabolism (IEM) in 8,000 patients from the state of Rio de Janeiro by qualitative and quantitative methods and the distribution of the diagnosed cases.
Michele G. S. C. Cypriani; Atecla N. L. Alves; Etelvino J. H. Bechara; Nilson A. AssunçãoHow to cite this article
High-performance liquid chromatography (HPLC)/fluorescence detection of porphyrins in a standard mixture of six porphyrinogens (black trace) and in the urine of a symptomatic carrier of acute intermittent porphyria (or porphyria cutanea tarda) (red trace). The excitation and emission wavelengths used were 400 and 620 nm, respectively.
Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil