JBCS

Dengue virus enzymes are important targets for antiviral drug design.

This review summarizes the chemical structure of dapsone, a drug used mainly in the treatment of leprosy and dermatitis, and its metabolism leads to the formation of toxic metabolites that cause adverse reactions, such as methemoglobinemia, which occurs because of the inability of methemoglobin to bind oxygen, causing a state of functional anemia.

The present review describes the synthesis of naphthoquinoidal compounds and their derivatives, their activities and mechanisms of action against Trypanosoma cruzi, the causative agent of Chagas disease.

The present review describes avenues recently explored for the search of behavior modifying compounds by means of high throughput methodologies. Specifically, examples of how such methodologies mediate the search for new repellents and attractants are described.

The main form of treatment for leishmaniasis and Chagas disease is still chemotherapy. There is no effective vaccine available and the search for new drugs is a priority. This review outlines the current understanding of different drugs against leishmaniasis and Chagas disease and the search for new drugs.

This study aimed to develop and validate a liquid cromatographic method for simultaneous determination of two sesquiterpene lactones from Tanacetum parthenium. A potencial tool for quality control of this medicinal plant with in vitro and in vivo antileishmaniasis activities.

Leishmanicidal galloylquinic acids from B. coccolobifolia showed as novel noncompetitive and mixed inhibitors of arginase from L. amazonensis.

Chemical composition of the hexane fractions from the leaves and branches of B. glaziovii that exhibited activity in the leishmanicidal tests as evaluated by high-resolution gas chromatography (HRGC) and GC- MS.

Co^III complexes with a family of thiosemicarbazones were evaluated for their anti-Mycobacterium tuberculosis effect. Complex 5 exhibited good activity with high selectivity index.

HPLC profile of three amino acids representative of the biochemical alterations found in maple syrup rinue disease, a metabolic disorder.

Monitoring of flavin mononucleotide fluorescence when exposed to solvent upon protein unfolding was used to determine flavoprotein melting temperature (Tm). Interaction of ligands to flavoproteins induces a shift in Tm and this phenomenon can be used on the screening of compounds as a tool for hit identification during the process of drug development.

Synthesis of galactose-containing triazol-arylsulfonamides and evaluation of Trypanosoma cruzi trans-sialidase inhibition, antitrypanosomal and cytotoxicity activities.

Preliminary evaluation demonstrated high leishmanicidal activity for aphidicolin and a new oxime derivative with selectivity for the L. braziliensis species.

Piperidine alkaloids (-)-cassine and (-)-spectaline isolated from the flowers of Senna spectabilids and semisynthetic derivatives (-)-3-O-acetylcassine and (-)-3-O-acetylspectaline were assessed for their antimalarial inhibitory activity by means of flow cytometry screening assay.

Thiophene derivatives obtained by Negishi reaction induced cell death on Leishmania braziliensis without inducing toxicity on macrophage.

The survey presents the results obtained after diagnostic investigation of inborn errors of metabolism (IEM) in 8,000 patients from the state of Rio de Janeiro by qualitative and quantitative methods and the distribution of the diagnosed cases.

High-performance liquid chromatography (HPLC)/fluorescence detection of porphyrins in a standard mixture of six porphyrinogens (black trace) and in the urine of a symptomatic carrier of acute intermittent porphyria (or porphyria cutanea tarda) (red trace). The excitation and emission wavelengths used were 400 and 620 nm, respectively.