JBCS

The influence of natural products on β-agonists/antagonists, anti-tumor and antiviral agents.

Limit metabolome space to drug space. Drug-like properties - Lipinski's rule-of-five. Use standards with known physicochemical properties to calibrate the column. Correlate log P to retention time (t_R).

Genes encoding the biosynthetic pathway for production of a valuable product (e.g., farnesene) in a native organism are expressed in a heterologous microbial host (e.g., yeast). The engineered yeast produces farnesene by commercial fermentation. Copyright c 2016 Amyris, inc. All rights reserved.

Elucidating the mode of action (MOA) and associated biomolecular targets of a natural product is often one of the bottlenecks in the drug discovery process. We present an overview of recent developments on an immunoaffinity fluorescent (IAF) approach that unites cellular microscopy with immunoaffinity target identification to rapidly characterize and subsequently validate the targets and cellular activity of natural products.

Highlighting the relevant literature from 1962 until 2015, on taxonomy, chemotaxonomy, traditional uses, pharmacological properties, chemical composition and ecological approach from Psychotria genus.

Benzoxazinoids constitute a diverse family of plant secondary metabolites with defensive roles against herbivores, pathogens, and competing plants. Their chemical properties and possible modes of action are discussed in the context of their biological activities.

Novel 1-substituted-phenyl-β-carbolines with an amino or guanidinium group-terminated side chain at C-3 were evaluated for in vitro anti-tuberculosis, antiproliferative properties and through in silico study.

Large scale purification process for steviol glycosides from a commercial crude extract of Stevia rebaudiana.

Replicons of Burkholderia thailandensis strains related to the production of three natural products (NPs). The biosynthetic gene clusters (BGCs) related to burkholdac were further analyzed and their side chain differentiation were tracked according to their genomes explaining the side chains modifications for this NP.

Workflow of the dereplication method: ¹H NMR data from F. oxyporum and F. solani extracts were subjected to principal component analysis (PCA) for the selection of important chemical shifts region (loading values), followed by dereplication algorithm that extracts real ¹H NMR peaks from the selected loading regions, enabling, through the comparison with an in-house NMR libraries and online databases, the identification of important bioactive metabolites in complex mixture.

This paper describes the isolation of the compounds ergosterol peroxide, monocerin, annularin I and annularin J of the biomass extracts of Exserohilum rostratum. The compounds annularin I and annularin J are new natural products.

The pericopine moth Scearctia figulina transforms pyrrolizidine alkaloids from their host plant Heliotropium transalpinum.

Medium composition modification locked verruculogen biosynthesis and addressed proline to the production of the cyclodepsipeptide JBIR 113 by the fungus P. brasilianum.

Volatiles from Dunaliella bardawil carotenoids produced by microwave irradiation and water bath controlled heating.

Phloea subquadrata (Heteroptera, Phloeidae) and two molecules of (E)-4-oxo-2-hexenal which dimerize in the scent gland.

Mining DNA coupled with networking and analytical tools is a new-fashioned strategy to guide dereplication and finding for new therapeutic targets.

Classification of authentic and commercial ginseng using multivariate statistical analysis with ultra-performance liquid chromatography (UPLC)-quadrupole time-of-flight (QTOF)-mass spectrometry.

Tissue specific volatile organic compounds (VOC) emissions from Oil Palm plantations into the atmosphere during fruit oil processing resulting in emissions of 6-methyl-5-hepten-2-one (MHO) as an oxidation biomarker of lycopene; pollinator attraction resulting in floral emissions of estragole, and leaf photosynthesis resulting in leaf emissions of isoprene. Individual tissue measurements of VOC emissions were made using plant enclosure methods while diurnal concentrations of ambient VOCs were made on a walkup flux tower at the plantation scale near Belém, Brazil.

Using LC-ESI-MS/MS analysis, five toxins ACTG-C, D, E and F, and AK-toxin II were identified in A. alternata, ACT-toxins appear to be absent.

This paper describes the structure elucidation of the male-produced sex pheromone of the soldier beetle Chauliognathus fallax through GC-EAD, GC-MS and GC-FTIR analyses, microderivatization and synthesis. The natural compound was identified as (Z)-tricos-11-ene.

Hybrids of plant phenolic natural products protocatechuic aldehyde, syringaldehyde or vanillin with (thio)urea were obtained and investigated for the potential as urease inhibitors of agricultural interest.