4:49, Mon Jul 22

Open Access/APCs

vol. 27, No. 8, 2016, p. 1319-1519


5th BCNP and XXXI RESEM: a Tribute to Biodiversity

Dreamers make dreams come true said Fed Kavli a Norwegian who wanted to help scientists to make the world a better place for future generations (1927‑2013). His dreams relied on astrophysics, nanoscience and neuroscience because he believed these were the tools for the future. However in my dreams I have always thought that natural products were important because they can lead us anywhere in Science. They were the origin of our life and will be our end if we do not take care of them.
(Read more at Editorial)

Special Issue on the 5th Brazilian Conference on Natural Products and XXXI Meeting on Micromolecular Evolution, Systematics and Ecology

Editorial J. Braz. Chem. Soc. 2016, 27(8), 1319

5th BCNP and XXXI RESEM: a Tribute to Biodiversity

Anita Jocelyne Marsaioli

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Review J. Braz. Chem. Soc. 2016, 27(8), 1320-1333

Natural Product-Derived Drugs Based on β-Adrenergic Agents and Nucleosides

David J. Newman

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The influence of natural products on β-agonists/antagonists, anti-tumor and antiviral agents.


Published online: March 4, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1334-1338

Turning Metabolomics into Drug Discovery

Asmaa Boufridi; Ronald J. Quinn

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Limit metabolome space to drug space. Drug-like properties - Lipinski's rule-of-five. Use standards with known physicochemical properties to calibrate the column. Correlate log P to retention time (tR).


Published online: March 18, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1339-1345

Developing Commercial Production of Semi-Synthetic Artemisinin, and of β-Farnesene, an Isoprenoid Produced by Fermentation of Brazilian Sugar

Kirsten R. Benjamin; Iris R. Silva; João P. Cherubim; Derek McPhee; Chris J. Paddon

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Genes encoding the biosynthetic pathway for production of a valuable product (e.g., farnesene) in a native organism are expressed in a heterologous microbial host (e.g., yeast). The engineered yeast produces farnesene by commercial fermentation. Copyright © 2016 Amyris, inc. All rights reserved.


Published online: April 15, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1346-1354

Elucidating the Mode of Action of Marine Natural Products through an Immunoaffinity Fluorescent (IAF) Approach

James J. La Clair; William Fenical; Leticia V. Costa-Lotufo

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Elucidating the mode of action (MOA) and associated biomolecular targets of a natural product is often one of the bottlenecks in the drug discovery process. We present an overview of recent developments on an immunoaffinity fluorescent (IAF) approach that unites cellular microscopy with immunoaffinity target identification to rapidly characterize and subsequently validate the targets and cellular activity of natural products.


Published online: May 10, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1355-1378

The Genus Psychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties

Nivea O. Calixto; Meri Emili F. Pinto; Suelem D. Ramalho; Marcela C. M. Burger; Antonio F. Bobey; Maria Claudia Marx Young; Vanderlan S. Bolzani; Angelo C. Pinto

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Highlighting the relevant literature from 1962 until 2015, on taxonomy, chemotaxonomy, traditional uses, pharmacological properties, chemical composition and ecological approach from Psychotria genus.


Published online: May 10, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1379-1397

Benzoxazinoids: Reactivity and Modes of Action of a Versatile Class of Plant Chemical Defenses

Felipe C. Wouters; Jonathan Gershenzon; Daniel G. Vassão

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Benzoxazinoids constitute a diverse family of plant secondary metabolites with defensive roles against herbivores, pathogens, and competing plants. Their chemical properties and possible modes of action are discussed in the context of their biological activities.


Published online: June 9, 2016

Articles J. Braz. Chem. Soc. 2016, 27(8), 1398-1405

Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activities of Novel β-Carboline Derivatives

Flora M. F. Moreira; Julio Croda; Maria H. Sarragiotto; Mary A. Foglio; Ana L. T. G. Ruiz; João E. Carvalho; Anelise S. N. Formagio

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Novel 1-substituted-phenyl-β-carbolines with an amino or guanidinium group-terminated side chain at C-3 were evaluated for in vitro anti-tuberculosis, antiproliferative properties and through in silico study.


Published online: February 26, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1406-1412

Development of HPLC Analytical Techniques for Diterpene Glycosides from Stevia rebaudiana (Bertoni) Bertoni: Strategies to Scale-Up

Douglas L. Rodenburg; Kamilla Alves; Wilmer H. Perera; Taylor Ramsaroop; Raquel Carvalho; James D. McChesney

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Large scale purification process for steviol glycosides from a commercial crude extract of Stevia rebaudiana.


Published online: March 18, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1413-1420

An Insight Into the Intraspecific Variation of Biosynthetic Gene Clusters Between Strains of Burkholderia thailandensis spp.

João Luiz Baldim; Marisi Gomes Soares

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Replicons of Burkholderia thailandensis strains related to the production of three natural products (NPs). The biosynthetic gene clusters (BGCs) related to burkholdac were further analyzed and their side chain differentiation were tracked according to their genomes explaining the side chains modifications for this NP.


Published online: April 7, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1421-1431

New Dereplication Method Applied to NMR-Based Metabolomics on Different Fusarium Species Isolated from Rhizosphere of Senna spectabilis

Denise M. Selegato; Rafael T. Freire; Alberto Tannús; Ian Castro-Gamboa

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Workflow of the dereplication method: 1H NMR data from F. oxyporum and F. solani extracts were subjected to principal component analysis (PCA) for the selection of important chemical shifts region (loading values), followed by dereplication algorithm that extracts real 1H NMR peaks from the selected loading regions, enabling, through the comparison with an in-house NMR libraries and online databases, the identification of important bioactive metabolites in complex mixture.


Published online: May 5, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1432-1436

Annularins I and J: New Metabolites Isolated from Endophytic Fungus Exserohilum rostratum

Eduardo A. A. Pinheiro; Fabio C. Borges; Jeferson R. S. Pina; Leila R. S. Ferreira; Jorgeffson S. Cordeiro; Josiwander M. Carvalho; André O. Feitosa; Francinete R. Campos; Andersson Barison; Afonso D. L. Souza; Patrícia S. B. Marinho; Andrey M. R. Marinho

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This paper describes the isolation of the compounds ergosterol peroxide, monocerin, annularin I and annularin J of the biomass extracts of Exserohilum rostratum. The compounds annularin I and annularin J are new natural products.


Published online: May 5, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1437-1443

Pyrrolizidine Alkaloids in the Pericopine Moth Scearctia figulina (Erebidae: Arctiinae): Metabolism and Chemical Defense

Carlos H. Z. Martins; José R. Trigo

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The pericopine moth Scearctia figulina transforms pyrrolizidine alkaloids from their host plant Heliotropium transalpinum.


Published online: May 17, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1444-1451

Copper and Manganese Cations Alter Secondary Metabolism in the Fungus Penicillium brasilianum

Taícia Pacheco Fill; Heloisa Fassina Pallini; Luciana da Silva Amaral; José Vinicius da Silva; Danielle Lazarin Bidóia; Francieli Peron; Francielle Pelegrin Garcia; Celso Vataru Nakamura; Edson Rodrigues-Filho

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Medium composition modification locked verruculogen biosynthesis and addressed proline to the production of the cyclodepsipeptide JBIR 113 by the fungus P. brasilianum.


Published online: May 25, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1452-1458

Generation of Volatile Compounds from Carotenoids of Dunaliella bardawil Algae by Water Bath Heating and Microwave Irradiation

Natália A. B. Tinoco; Thais M. Uekane; Anna Tsukui; Paula F. de Aguiar; Cláudia M. L. L. Teixeira; Claudia M. Rezende

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Volatiles from Dunaliella bardawil carotenoids produced by microwave irradiation and water bath controlled heating.


Published online: June 1, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1459-1464

(E)-4-Oxo-2-hexenal Dimers in the Scent Glands of the Bark Bug Phloea subquadrata (Heteroptera, Phloeidae)

Francine S. A. da Fonseca; Marília Medeiros; Adriana T. Salomão; João Vasconcellos-Neto; Anita J. Marsaioli

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Phloea subquadrata (Heteroptera, Phloeidae) and two molecules of (E)-4-oxo-2-hexenal which dimerize in the scent gland.


Published online: June 10, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1465-1475

Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability

Célio F. F. Angolini; Ana B. Gonçalves; Renata Sigrist; Bruno S. Paulo; Markiyan Samborskyy; Pedro L. R. Cruz; Adriana F. Vivian; Eduardo M. Schmidt; Marcos N. Eberlin; Welington L. Araújo; Luciana G. de Oliveira

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Mining DNA coupled with networking and analytical tools is a new-fashioned strategy to guide dereplication and finding for new therapeutic targets.


Published online: June 10, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1476-1483

Chemical Profiling of Ginseng Species and Ginseng Herbal Products Using UPLC/QTOF-MS

Jimmy Yuk; Dhavalkumar N. Patel; Giorgis Isaac; Kerri Smith; Mark Wrona; Hernando J. Olivos; Kate Yu

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Classification of authentic and commercial ginseng using multivariate statistical analysis with ultra-performance liquid chromatography (UPLC)-quadrupole time-of-flight (QTOF)-mass spectrometry.


Published online: June 21, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1484-1492

Diurnal Pattern of Leaf, Flower and Fruit Specific Ambient Volatiles above an Oil Palm Plantation in Pará State, Brazil

Kolby J. Jardine; Bruno O. Gimenez; Alessandro C. Araújo; Roberto L. Cunha; Juliana Feitosa Felizzola; Luani R. Piva; Jeffrey Q. Chambers; Niro Higuchi

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Tissue specific volatile organic compounds (VOC) emissions from Oil Palm plantations into the atmosphere during fruit oil processing resulting in emissions of 6-methyl-5-hepten-2-one (MHO) as an oxidation biomarker of lycopene; pollinator attraction resulting in floral emissions of estragole, and leaf photosynthesis resulting in leaf emissions of isoprene. Individual tissue measurements of VOC emissions were made using plant enclosure methods while diurnal concentrations of ambient VOCs were made on a walkup flux tower at the plantation scale near Belém, Brazil.


Published online: June 28, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1493-1505

Rapid Detection of ACTG- and AK-Toxins in Alternaria alternata by LC-ESI-MS/MS Analysis and Antifungal Properties of Citrus Compounds

Kátia R. Prieto; Lívia S. de Medeiros; Marsele M. Isidoro; Leonardo Toffano; Maria Fátima G. F. da Silva; João B. Fernandes; Paulo C. Vieira; Moacir R. Forim; Edson Rodrigues-Filho; Rodrigo M. Stuart; Marcos A. Machado

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Using LC-ESI-MS/MS analysis, five toxins ACTG-C, D, E and F, and AK-toxin II were identified in A. alternata, ACT-toxins appear to be absent.


Published online: June 28, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1506-1511

Identification and Synthesis of the Male-Produced Sex Pheromone of the Soldier Beetle Chauliognathus fallax (Coleoptera: Cantharidae)

Diogo M. Vidal; Carla F. Fávaro; Matheus M. Guimarães; Paulo H. G. Zarbin

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This paper describes the structure elucidation of the male-produced sex pheromone of the soldier beetle Chauliognathus fallax through GC-EAD, GC-MS and GC-FTIR analyses, microderivatization and synthesis. The natural compound was identified as (Z)-tricos-11-ene.


Published online: July 1, 2016

J. Braz. Chem. Soc. 2016, 27(8), 1512-1519

Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

Lívia P. Horta; Yane C. C. Mota; Gisele Maria Barbosa; Taniris C. Braga; Ivanildo E. Marriel; Ângelo de Fátima; Luzia V. Modolo

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Hybrids of plant phenolic natural products protocatechuic aldehyde, syringaldehyde or vanillin with (thio)urea were obtained and investigated for the potential as urease inhibitors of agricultural interest.


Published online: July 13, 2016

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
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