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Open Access/APCs

vol. 28, No. 3, 2017, p. 391-519


The Challenge of Including Chemodiversity, and the Potential Economic Use of New Natural Compounds and Processes, in the BIOTA/FAPESP Program

Biological diversity, or biodiversity, is the term used to define the variety of life on Earth. It is the combination of life forms and their interactions with one another, and with the physical environment that has made Earth habitable for humans. Throughout the evolutionary process of the planet ecosystems, underpinned by biodiversity, provided the basic necessities for life in Earth. For mankind this support, currently named ecosystem services, provided and continue to provide from food production through pollination to soil stability, which reduces the possibility of landslides, as well as cultural and spiritual services. Thus, the loss of biodiversity constitutes a critical problem for the future of the Earth and for humankind. Therefore all kind of investments towards biodiversity science is amply recognized as a priority, and a flourishing area of scientific research in both the developed and developing countries.

(Read more at Editorial)

Special Issue BIOprospecTA - BIOTA

Editorial J. Braz. Chem. Soc. 2017, 28(3), 391-392

The Challenge of Including Chemodiversity, and the Potential Economic Use of New Natural Compounds and Processes, in the BIOTA/FAPESP Program

Carlos A. Joly; Vanderlan S. Bolzani

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Account J. Braz. Chem. Soc. 2017, 28(3), 393-401

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Mônica T. Pupo; Cameron R. Currie; Jon Clardy

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The fungus-growing ants multilateral symbiosis between three mutualists and one parasite as the rational guide for the discovery of natural products hits and leads.


Published online: October 25, 2016

Review J. Braz. Chem. Soc. 2017, 28(3), 402-414

The Influence of Brazilian Biodiversity on Searching for Human Use Pharmaceuticals

David J. Newman

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The microbial biosynthetic genes that produced the toxin in the blister beetle are almost the same as those that produced similar toxins in deep and shallow water sponges. Thus "Mother Nature" reuses useful genes apparently across kingdoms. Read the full story in the review.


Published online: August 3, 2016

J. Braz. Chem. Soc. 2017, 28(3), 415-426

Update: Biological and Chemical Aspects of Senna spectabilis

Denise M. Selegato; Afif F. Monteiro; Natália C. Vieira; Patrícia Cardoso; Victor D. Pavani; Vanderlan S. Bolzani; Ian Castro-Gamboa

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This review aims to provide an updated summary of the main features of Senna spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and associated microorganisms.


Published online: December 15, 2016

Articles J. Braz. Chem. Soc. 2017, 28(3), 427-434

An UPLC-MS/MS Method for Determination of Vicenin-2 and Lychnopholic Acid in Rat Plasma and its Application to a Pharmacokinetic Study

Dayana R. Gouvea; Gabriela A. Buqui; João Luis C. Lopes; Andrea Diniz; Norberto P. Lopes

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A validated UPLC-MS/MS methodology demonstrated that vicenin-2 and lychnofolic acid compounds were distributed and rapidly eliminated from the rat organism.


Published online: August 31, 2016

J. Braz. Chem. Soc. 2017, 28(3), 435-442

Evaluation of Chemical Defense and Chemical Diversity in the Exotic Bryozoan Amathia verticillata

Larissa A. H. dos Santos; Etiene E. G. Clavico; Lizbeth L. L. Parra; Roberto G. S. Berlinck; Antonio G. Ferreira; Valerie J. Paul; Renato C. Pereira

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Predation of the bryozoan Amathia verticillata by fishes in field assays showed variable results depending on the region where the bryozoan is found. The results indicate that A. verticillata indole alkaloids play no significant role as chemical defenses.


Published online: September 15, 2016

J. Braz. Chem. Soc. 2017, 28(3), 443-454

Identification of Triterpenoids from Schefflera systyla, Odontadenia puncticulosa and Conostegia speciosa and In Depth Investigation of Their in vitro and in vivo Antifungal Activities

Quentin Favre-Godal; Stephane Dorsaz; Laurence Marcourt; Valentina Bertini; Emmanuelle Dormia; Emilie Michellod; Francine Voinesco; Mahabir Gupta; Katia Gindro; Dominique Sanglard; Emerson F. Queiroz; Jean-Luc Wolfender

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Characterization of the antifungal triterpenoids isolated from Panamanian plants against Candida species.


Published online: October 5, 2016

J. Braz. Chem. Soc. 2017, 28(3), 455-464

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth. Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity

Rogério Grando; Vanessa H. Souza; Karin M. Monteiro; Ilza M. O. Sousa; Nubia C. A. Queiroz; João E. Carvalho; Humberto M. Spindola; Mary A. Foglio

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Data demonstrates the antinociceptive activity of aqueous P. pubescens fruit extract, with lower potency compared to dichloromethane P. pubescens fruit extract. Nevertheless the resulting data corroborates the species folk use.


Published online: October 21, 2016

J. Braz. Chem. Soc. 2017, 28(3), 465-474

Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Actinomadura sp. Collected at the Saint Peter and Saint Paul Archipelago (Brazil)

Amaro E. T. Silva; Larissa A. Guimarães; Elthon G. Ferreira; Maria da Conceição M. Torres; Alison B. da Silva; Paola C. Branco; Francisca Andréa S. Oliveira; Genivaldo G. Z. Silva; Diego V. Wilke; Edilberto R. Silveira; Otília Deusdenia L. Pessoa; Paula C. Jimenez; Leticia V. Costa-Lotufo

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Chemical studies and genome mining of Actinomadura sp. isolated from sediments collected at the St. Peter and St. Paul Archipelago led to the characterization of three cytotoxic prodiginine derivatives.


Published online: November 11, 2016

J. Braz. Chem. Soc. 2017, 28(3), 475-484

Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration

Marilia Valli; Wanessa Altei; Ricardo N. dos Santos; Emilio C. de Lucca Jr.; Marco A. Dessoy; Renan M. Pioli; Fernando Cotinguiba; Xavier Cachet; Sylvie Michel; Maysa Furlan; Luiz C. Dias; Adriano D. Andricopulo; Vanderlan S. Bolzani

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Natural product piperlongumine and synthetic analogue designed as inhibitor of breast cancer cell line migration.


Published online: November 17, 2016

J. Braz. Chem. Soc. 2017, 28(3), 485-491

Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis

Francisco C. L. Pinto; José Gustavo L. Almeida; Edilberto R. Silveira; Arinice M. Costa; Larissa A. Guimarães; Diego V. Wilke; Letícia V. Costa-Lotufo; Maria da Conceição M. Torres; Otília Deusdênia L. Pessoa

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Nine ergostan sterols, including two previously unknown, were isolated from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of all compounds were determined, particularly by 1D and 2D NMR data and HRESIMS.


Published online: December 15, 2016

Short Report J. Braz. Chem. Soc. 2017, 28(3), 492-497

Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae)

Thiago R. Morais; Ana Paula R. Coutinho; Fernanda F. Camilo; Tereza S. Martins; Patricia Sartorelli; Mariana H. Massaoka; Carlos R. Figueiredo; João Henrique G. Lago

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Microwave assisted extraction and ionic liquid was used to obtain cytotoxic metabolites from Schinus terebinthifolius.


Published online: July 19, 2016

J. Braz. Chem. Soc. 2017, 28(3), 498-504

Multiple Monohydroxylation Products from rac-Camphor by Marine Fungus Botryosphaeria sp. Isolated from Marine Alga Bostrychia radicans

Hugo C. R. de Jesus; Alex H. Jeller; Hosana M. Debonsi; Péricles B. Alves; André L. M. Porto

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Monohydroxylation of rac-camphor yielding hydroxylated diastereoisomers at positions C-3, C-5, C-6 and C-8.


Published online: September 26, 2016

J. Braz. Chem. Soc. 2017, 28(3), 505-511

Rosmarinic and Cinnamic Acid Derivatives of in vitro Tissue Culture of Plectranthus ornatus: Overproduction and Correlation with Antioxidant Activities

Héctor H. Medrado; Edlene O. dos Santos; Erika M. O. Ribeiro; Jorge M. David; Juceni P. David; José Fernando Araújo; Ademir E. do Vale; Moema C. Bellintani; Hugo N. Brandão; Paloma R. Meira

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Tissue culture of Plecthrantus ornatus on Murashige and Skoog (MS) medium with the addition of auxin and cytokinin promotes an overproduction of rosmarinic and caffeic acids.


Published online: November 17, 2016

J. Braz. Chem. Soc. 2017, 28(3), 512-519

Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation

Vivian E. Cornelio; Fernando V. Maluf; João B. Fernandes; Maria Fátima G. F. da Silva; Glaucius Oliva; Rafael V. C. Guido; Paulo C. Vieira

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Bioactivity-guided TcGAPDH assay leading to isolation of tiliroside from Spiranthera odoratissima extract.


Published online: December 7, 2016

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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