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vol. 35, No. 1, 2024, p. 1-32

 

This image represents a review article that summarizes the development and application of new compounds in the control of breast cancer. Three distinct chemical classes are highlighted: photosensitizers, caged xanthones, and thiosemicarbazones. The review emphasizes progress in drug development, covering design, structure-activity relationships, and the anti-cancer attributes of each chemical class, which represents potential alternatives to current treatment limitations. Details are presented in the Review Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives by Douglas D. S. Oliveira, Thibault J. W. Jacques Dit Lapierre, Fernanda C. Silva, Ieda V. Cunha, Rafael A. C. Souza, Patrícia A. Matos, Gustavo M. Almeida, Carolina G. Oliveira, Thaise G. Araújo, Tayana M. Tsubone and Celso O. Rezende Jr. on e-20230128.


Cover Article
J. Braz. Chem. Soc. 2024, 35(1), 1-32

Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives

Douglas D. S. Oliveira; Thibault J. W. Jacques Dit Lapierre ; Fernanda C. Silva; Ieda V. Cunha; Rafael A. C. Souza;
Patrícia A. Matos ; Gustavo M. Almeida; Carolina G. Oliveira ; Thaise G. Araújo; Tayana M. Tsubone ; Celso O. Rezende Jr.

How to cite this article

This image represents a review article that summarizes the development and application of new compounds in the control of breast cancer. Three distinct chemical classes are highlighted: photosensitizers, caged xanthones, and thiosemicarbazones. The review emphasizes progress in drug development, covering design, structure-activity relationships, and the anti-cancer attributes of each chemical class, which represents potential alternatives to current treatment limitations. Details are presented in the Review Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives by Douglas D. S. Oliveira, Thibault J. W. Jacques Dit Lapierre, Fernanda C. Silva, Ieda V. Cunha, Rafael A. C. Souza, Patrícia A. Matos, Gustavo M. Almeida, Carolina G. Oliveira, Thaise G. Araújo, Tayana M. Tsubone and Celso O. Rezende Jr. on e-20230128.

https://dx.doi.org/10.21577/0103-5053.20230128

Published online: August 4, 2023
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Editorial J. Braz. Chem. Soc. 2024, 35(1), 1

Welcome to 2024

Paulo Cezar Vieira

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https://dx.doi.org/10.21577/0103-5053.20230198

Total access: 210


Account J. Braz. Chem. Soc. 2024, 35(1), 1-18

The Art of Scientific Writing and Ethical Use of Artificial Intelligence

Brenno Amaro D. Neto ; Marcos N. Eberlin

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Scientific writing from first words to publication, as well as its challenges, including ethical aspects, are presented and discussed in this opinion manuscript.

https://dx.doi.org/10.21577/0103-5053.20230121

Published online: July 26, 2023

 

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Review J. Braz. Chem. Soc. 2024, 35(1), 1-32

Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives

Douglas D. S. Oliveira; Thibault J. W. Jacques Dit Lapierre ; Fernanda C. Silva; Ieda V. Cunha; Rafael A. C. Souza;
Patrícia A. Matos ; Gustavo M. Almeida; Carolina G. Oliveira ; Thaise G. Araújo; Tayana M. Tsubone ; Celso O. Rezende Jr.

How to cite this article

 

This review presents the principal aspects of the drug discovery process targeting breast cancer and highlights the most promising derivatives of caged xanthones and thiosemicarbazones explored in conventional therapy. Also, it presents details of photodynamic therapy and the action of photosensitizers as an alternative therapy for breast cancer.

https://dx.doi.org/10.21577/0103-5053.20230128

Published online: August 4, 2023

 

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Total access: 1745


J. Braz. Chem. Soc. 2024, 35(1), 1-18

Biochar and Hydrochar in the Development and Application of Electrochemical Devices in the Sensing and Degradation of Target Compounds: A Mini-Review of the Recent Contributions of 2020-2023

Jonatas O. S. Silva ; Honnara S. Granja ; José F. dos Santos ; Lisiane S. Freitas ; Eliana M. Sussuchi

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We discuss the use of biochars and hydrochars in electrodes applied in the electrochemical sensing and degradation of target compounds.

https://dx.doi.org/10.21577/0103-5053.20230143

Published online: August 22, 2023

 

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J. Braz. Chem. Soc. 2024, 35(1), 1-16

The World of Cave Microbiomes: Biodiversity, Ecological Interactions, Chemistry, and the Multi-Omics Integration

Natália N. Kato; Gabriel S. Arini; Ricardo Roberto Silva; Maria Elina Bichuette; José Augusto P. Bitencourt; Norberto P. Lopes

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The cave ecosystem hosts a high diversity of microorganisms with complex strategies to survive in limited environmental conditions. Here, we highlight the biology and chemistry of cave microbiomes with multi-omics perspectives.

https://dx.doi.org/10.21577/0103-5053.20230148

Published online: September 1, 2023

 

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Articles J. Braz. Chem. Soc. 2024, 35(1), 1-9

Anaerobically Treated Leachate from a Composting Plant: Characterization and Evaluation as a Biofertilizer

Rita de Cássia M. Freire; Adalin Cezar M. de Aguiar; Mayra Aparecida Nascimento; Felipe S. O. Cruz; Ann H. Mounteer; Antônio Alberto Silva; Renata P. Lopes

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This work presents a compost effluent that has been successfully applied as biofertilizer in lettuce crops.

https://dx.doi.org/10.21577/0103-5053.20230085

Published online: May 30, 2023

 

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Total access: 978


J. Braz. Chem. Soc. 2024, 35(1), 1-12

Corrosion Behavior of NdFeB Magnets in Different Aqueous Solutions

Ana-Maria Popescu; Jose M. Calderon-Moreno; Kazimir Yanushkevish; Alexei Aplevich; Olga Demidenko; Elena Ionela Neacsu; Virgil Constantin

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A comprehensive study on the corrosion behavior of NdFeB magnets in different electrolytes.

https://dx.doi.org/10.21577/0103-5053.20230089

Published online: June 2, 2023

 

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Total access: 1003


J. Braz. Chem. Soc. 2024, 35(1), 1-12

In silico and Experimental Assessments Applied to Preliminary Identification of New Illicit Substances Structures

Karen P. S. Lopes; Maria C. C. Lucena; Thiago Inacio B. Lopes; Ámison R. L. da Silva ; Leonardo P. da Silva ; Norberto K. V. Monteiro ; Pedro de Lima-Neto ; Nágila M. P. S. Ricardo

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Study of infrared in silico data as a standard database in preliminary method for new synthetic seized drugs.

https://dx.doi.org/10.21577/0103-5053.20230090

Published online: June 6, 2023

 

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Total access: 1000


J. Braz. Chem. Soc. 2024, 35(1), 1-13

Microstructural, Morphological, and Optical Study of Synthesis of ZnO and Pt‑ZnO Nanoparticles by a Simple Method Using Different Precipitating Agents

Ruby S. Gines-Palestino ; Carlos Montalvo-Romero; Guadalupe Luna-Solano; Luis P. Amador-Gómez; Denis Cantú-Lozano

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In this research, ZnO and Pt-ZnO were synthesized by a simple method using two different precursors (KOH and NaOH).

https://dx.doi.org/10.21577/0103-5053.20230092

Published online: June 6, 2023

 

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J. Braz. Chem. Soc. 2024, 35(1), 1-8

Synthesis, in vitro Toxicity, and Antitrypanosomal Activity of Arylated and Diarylated Thiazoles

Kelly L. Figueira; Roberson D. Girão ; Krislayne N. da Costa; Ana C. R. Barreto; Maria de Nazaré C. Soeiro; Jones Limberger

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Synthesis of pyridyl-substituted arylthiazoles with low toxic potential and highly active against Trypanosoma cruzi (half maximal effective concentration (EC50) = 1-2 µM).

https://dx.doi.org/10.21577/0103-5053.20230094

Published online: June 13, 2023

 

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Total access: 1299


J. Braz. Chem. Soc. 2024, 35(1), 1-12

Revisiting the Synthesis of Gibbsite, a Precursor for Li/Al LDH Synthesis and Its Use as a Support for Porphyrin Immobilization

Gabriela Bosa; Caroline G. Silva; Bianca R. Brito; Carolina M. Terzi; Fernando Wypych ; Shirley Nakagaki

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Some of the synthesis methods already reported for aluminum(III) hydroxide compounds with layered structure of the gibbsite polytype are revisited. The obtained gibbsite material was used as an Al precursor for the synthesis of a lithium/aluminum layered double hydroxide (LDH) and the LDH was used for the immobilization of an anionic porphyrin.

https://dx.doi.org/10.21577/0103-5053.20230095

Published online: June 13, 2023

 

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Total access: 967


J. Braz. Chem. Soc. 2024, 35(1), 1-13

Evaluation of Free- and Bound-Carbonyl Compounds in Craft Beers

Marinice S. S. Acácio; Eliete C. Alves; Jailson B. de Andrade ; Jeancarlo P. dos Anjos

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Carbonyl compounds can be present in beer in free and bound forms. All craft beer samples showed bound-carbonyl compounds, which can negatively influence on the quality of the beverage.

https://dx.doi.org/10.21577/0103-5053.20230100

Published online: June 21, 2023

 

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Total access: 806


J. Braz. Chem. Soc. 2024, 35(1), 1-7

Mucuna cinerea Seeds: Levodopa Extraction Using Deep Eutectic Solvent and Its Mammalian Cell Activity

Bruna T. Silva; Antonio J. Demuner ; Daiane E. Blank; Mateus G. Campos; Tiago A. O. Mendes

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Levodopa (L-dopa) of Mucuna cinerea was extracted using deep eutectic solvents (DES). Three extracts L-dopa/DES presented control of Parkinson's disease in human glandular kallikrein-1 gene (hGK3) and G protein-coupled receptor kinase-6 gene (GRK6).

https://dx.doi.org/10.21577/0103-5053.20230101

Published online: June 22, 2023

 

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J. Braz. Chem. Soc. 2024, 35(1), 1-16

Impact of Conservation Processes on the Lipid Profile and Immunological Factors IL-10 and TGF-β1 in Whey Separated from Discarded Human Milk

Eloize S. Alves; Matheus C. Castro; Bruno H. F. Saqueti; Luciana P. Manin ; Josiane B. Alencar; Joana M. V. Zacarias; Andressa R. S. Bruni; Grasiele S. Madrona; Jeane E. L. Visentainer; Marcelo Cristianini; Oscar O. Santos ; Jesui V. Visentainer

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Different processes were evaluated under the lipid and immunological quality of whey human, and the search for the guarantee of nutrients was facilitated. Thus, adapting the processed human whey for use as a complementary product for infant food introduction.

https://dx.doi.org/10.21577/0103-5053.20230102

Published online: June 26, 2023

 

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J. Braz. Chem. Soc. 2024, 35(1), 1-8

Polymer-Supported Dibutylstannyl Azide: An Efficient and Recoverable Reagent in the One-Pot Synthesis of Aryl Azides and 5-Aryl 1H-tetrazoles

Leonela Godoy Prieto; María T. Lockhart; Marcos J. Lo Fiego

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An efficient polymer-supported organotin azide in the synthesis of aryl azides and 5-aryl 1H-tetrazoles.

https://dx.doi.org/10.21577/0103-5053.20230104

Published online: June 27, 2023

 

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Total access: 733


J. Braz. Chem. Soc. 2024, 35(1), 1-8

Investigating the Expression of Genes Involved in Apoptosis and Mutation in Ovarian Cancer Cell Line and Possible Hepatotoxicity in Rats Induced by New Green Synthesized Ag-NPs

Fang Fang; Xiaoyan Zhang; Rongrong Bai; Bing Wang ; Mostafa Heidari Majd

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Silver nanoparticles synthesized by Moringa peregrina leaves extract increase the expression of genes involved in apoptosis in both intrinsic and extrinsic pathways. It also prevents cancer mutation.

https://dx.doi.org/10.21577/0103-5053.20230105

Published online: June 27, 2023

 

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J. Braz. Chem. Soc. 2024, 35(1), 1-11

Supramolecular Assembly between Cationic Pyridinium-Pillararene and Aminosalicylate Drug

Willian Demos; Lizandra C. B. Micke; Luis H. S. Lacerda ; Bruno S. Souza ; Adriana P. Gerola ; Ricardo F. Affeldt

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Fluorescence quenching of mesalazine drug due to interaction with positive-charged pillararene macrocycle at neutral pH.

https://dx.doi.org/10.21577/0103-5053.20230106

Published online: June 30, 2023

 

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Total access: 832


Short Report J. Braz. Chem. Soc. 2024, 35(1), 1-5

Gas-Phase Fragmentation Reactions of Protonated Pumiliotoxin (+)-251D and Allopumiliotoxin (+)-267A in ESI-MS/MS

Basil Minder ; Jacqueline N. Mendonça; Taran Grant ; Norberto P. Lopes

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The analysis of gas phase fragmentation reactions in electrospray ionization tandem mass spectrometry (ESI-MS/MS) allowed for the first time to elucidate all ions originating from protonated pumiliotoxin (+)-251D and allopumiliotoxin (+)-267A.

https://dx.doi.org/10.21577/0103-5053.20230099

Published online: June 20, 2023

 

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Total access: 1002

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

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