JBCS

The synthesis of molecularly imprinted polymers (MIPs) for scopolamine via bulk polymerization, combined with a 3D-printed device, aims to remove the drug from contaminated drinks, thereby preventing unwanted ingestion and potential crimes facilitated by the drug.

A multi-step in silico pipeline was used to screen 821 lanostane triterpenes against the N-methyl-D-aspartate (NMDA) receptor, identifying three lead candidates with high affinity and potential as fast-acting antidepressants.

The integrated approach of genome mining with mass spectrometry sheds light on the biosynthesis pathway of oosporein (OOS) and analogous compounds in the culture of Arcopilus amazonicus.

The figure illustrates the in situ Raman spectroscopic monitoring of the Vilsmeier-Haack cyanation of pyrrole and indole. The visual flow represents the progression of the reaction through substrates, intermediates, and finally, the products, with Raman spectra evidencing the molecular transformations.

This study developed a Brazilian amphetamine hydrochloride certified reference material to support forensic analyses, in partnership with the University, Institute of Metrology, Quality and Technology (Inmetro), and the Federal Police.

A novel polytrimethylene ether glycol (PO3G) oligomer microwave assisted synthesis with attenuated total reflectance Fourier transformed infrared (ATR-FTIR) reaction monitoring, moving forward into the green chemistry.

Nonconventional extraction techniques, ultrasound-assisted and pressurized liquid extractions were compared to dynamic maceration, using ethanol as the solvent, to extract antioxidant compounds, especially ascorbic acid, from camu-camu fruits.

In silico analysis suggests that soy isoflavonoids such as 8-hydroxydaidzein and dihydrogenistein may inhibit androgen receptor signaling in prostate cancer, requiring further research.

Through a two-step deoxygenative olefination approach, we synthesized three stachene natural products from isosteviol, including the first reported synthesis of (+)-nidoanomalin.

Chamaerops humilis fruit pulp was hydrothermally carbonized and subsequently activated by H₃PO₄ to perform Methylene Blue adsorption using hydrochar-activated carbon (CHHAC). Material characterization (scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR)), adsorption experiments, and response surface methodology (RSM) modeling were carried out to optimize conditions, determine performance, and evaluate reusability.

This study reports the synthesis and biological evaluation of a series of 2-(quinolin-4-yloxy) acetamides as antitubercular agents. The work highlights the structure-activity relationships, cytotoxicity, and aqueous solubility of the most active derivatives, identifying compound 6o as a valuable scaffold for future medicinal chemistry efforts.

A new recycling route for polyethylene terephthalate (PET) waste was developed through its partial depolymerization with glycerol, yielding a material with potential adsorbent properties.

Secondary metabolites from species of the Spondias genus were evaluated as potential inhibitors of monoamine oxidase A (MAO-A) through molecular docking studies and in vitro assays. The results revealed high binding affinity and enzyme inhibition, suggesting promising candidates for the treatment of depression.

Natural organic residues enriched with Ca and Mg for application in lettuce grown in water depths demonstrated positive results in crop growth and development.

OncoTherad (MRB-CFI-1), a novel nanoimmunotherapy developed in Brazil, activates innate immune system toll like receptors pathways to enhance antitumor immunity. This cost-effective innovation exemplifies scalable immunotherapy from the Global South.

The physical and chemical stability of emulsions containing a piceatannol-rich extract from passion fruit seeds, a spilanthol-rich extract from paracress, and UV filters was assessed by UV-Vis, analytical centrifugation, thermal analyses, and exposure to temperature cycles.

Binding of ligands to the Chromobox 4 (CBX4) protein to prevent potential oxidative stress and noise-induced deafness.

Laser-induced breakdown spectroscopy (LIBS) and hyperspectral imaging enable real-time monitoring and control of metal leaching from e-waste, supporting efficient and sustainable resource recovery.

The polydimethylsiloxane/polyvinylidene fluoride (PDMS/PVDF) membrane had the best hydrophobicity (145.2°), and the separation efficiency could still reach 95.0% after 20 cycles.

In general, in the upper Doce River, the concentration of As, Cr, Cu, Fe, Mn, Ni, and Pb exceeds the maximum limits of the Brazilian Resolution in the rainy season.

Malt bagasse residue is converted by sustainable method into P-doped hydrochar and applied as support of Co-Ni nanocatalysts for H₂ evolution.

Melaleuca alternifolia essential oil nanoemulsion was developed for pharma cosmetic applications, with a detailed analysis of its components, thermal stability evaluation, and droplet size characterization.

Binding mode of compound 16d (potential inhibitor) in the active site of the dissimilatory adenosine 5'-phosphosulfate reductase (APSrAB).

Simulated UV-Vis absorption spectrum of probe and sulfite adduct based on PBE0/def2TZVPD method.

The figure presents the methodological flow of the study of the volatile chemical constituents of Myrciaria tenella. The botanical identification of the species was performed, followed by the extraction of volatile compounds by hydrodistillation. The samples were analyzed by gas chromatography coupled with mass spectrometry to identify (E)-caryophyllene, δ-cadinene, α-calacorene, caryophyllene oxide, and 1-epi-cubenol. Finally, the data obtained were subjected to multivariate statistical analyses.

Analysis of input files from Atmospheric Global Emission Inventory in the State of Rio de Janeiro.

Probing tailored interactions between doxorubicin and surface modified gold nanoparticles by surface-enhanced Raman scattering (SERS) spectroscopy.

Representation of the bacterial cellulose (BC) production process using pulp juice from Cereus jamacaru DC fruit fermented with Komagataeibacter hansenii. The steps include the raw fruit, preparation of the medium, and the wet and dry forms of BC.

Amino acid-modified branched polyethyleneimines enable safer and more efficient deoxyribonucleic acid (DNA) delivery via polyplex formation, offering novel possibilities, including ocular gene therapy.

Phytochemical study of Ocotea neesiana demolition wood led to the purification of eight compounds. The sesquiterpene α-cadinol and the diterpene 16-methylesteritol A exhibited antibacterial potential against Xanthomonas citri subsp. citri.

Cigarette filters were pyrolyzed to obtain bio-oil and biochar aiming at efficient CO₂ adsorption.

This study highlights the importance of combining in silico analysis with experimental techniques, emphasizing the need for careful handling of simvastatin, particularly concerning the formation of hydrolysis products, oxidation, and light exposure.

Lignin depolymerization was done using an Au/Pd@TiO₂ via three subsequent reactions (alcohol oxidation, photo-cleavage and hydrogenolysis) under light irradiation (UV or green light).

A low-cost, 3D-printed liquid handling robot enables autonomous calibration, precise analytical management, and advanced flow analysis, integrating electrochemical and colorimetric detection for unprecedented automation.

The platinum nanoparticles (Pt NPs)/MnWO₄ composite was synthesized and showed to be an efficient, reusable catalyst for H₂ generation via NaBH₄ hydrolysis.

A method was developed and validated, by the application of 3² factorial, for the monitoring of azithomycin (AZM) and its impurities.

A comprehensive review of the chemistry and biological activities of koningins and related fungal octaketides.

Application of ultrasound and conventional methods to alpaca fibers, demonstrating the absorption of the dyes Synozol Red K3BS and Novacron Navy FN-BN.

Flowchart summarizing the steps used to conduct virtual screening and identify potential selective inhibitors of Leishmania chagasi dihydrofolate reductase-thymidylate synthase (LcDHFR-TS).

Study of the energy content, fatty acid composition and cytokines tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) content in mature human milk at different breastfeeding intervals (foremilk, middle milk, and hindmilk).