Isatin, a Versatile Molecule: Studies in Brazil
Bárbara V. SilvaHow to cite this article
Isatin was synthesised in 1840 before it was discovered in the nature. Its derivatives are found in the parotid gland secretions of the Bufo frog, in the egg masses of the Australian mollusc Dicathais orbita, in plants of the Isatis genus and in the species Couroupita guianensis, Aubl, Melochia tomentosa and Boronella koniamboensis. It is an important raw material for the synthesis of a wide spectrum of bioactive compounds. Its derivatives exhibit antiviral, anti-inflammatory, anticonvulsant and antitumor activities, among others. This account discusses studies performed by several Brazilian research groups, including the investigations of its structural changes, the design of biological assays and some novel synthesis routes. Details are presented in the Account Isatin, a Versatile Molecule: Studies in Brazil by Bárbara V. Silva on page 707.
Bárbara V. SilvaHow to cite this article
Isatin is a small, versatile and widely applicable pharmacological molecule. Several Brazilian research groups have actively contributed to the development of novel synthetic routes to isatin derivatives, structural studies and the design of biological assays.
Danielle Goveia; Camila de A. Melo; Lilian K. de Oliveira; Leonardo F. Fraceto; Julio Cesar Rocha; Newton Luiz Dias Filho; André Henrique RosaHow to cite this article
Scheme of the analytical procedure used to determine the micronutrient adsorption/desorption capacity of humin extracted from peat samples. Conditions: ultrafiltration system (Sartorius Ultrasart X), 1 kDa polyethersulfone membrane (Gelman Pall-Filtron OMEGA).
Gustavo G. Shimamoto; Juliana Terra; Maria Izabel M. S. BuenoHow to cite this article
The figure shows the steps to grouping nail polish samples depending on their brands to contribute as an useful evidence in forensic science. The proposed methodology is a quick, low cost and green alternative.
Emre Yavuz; Şerife Tokalıoğlu; Serkan ŞahanHow to cite this article
5-(p-Dimethylaminobenzylidene) rhodanine (PDR) is a derivative of rhodanine that is especially suitable as a sensitive and highly selective reagent for silver. It forms slightly soluble red precipitate with Ag(I).
Carla Toledo-Neira; Pedro Enríquez; Pablo RichterHow to cite this article
Integrated Pressurized liquid extraction (PLE) with solid phase extraction (SPE) cleanup method was developed for determination of polychlorinated biphenyls in chicken and pork meat samples. Extraction variables were optimized by experimental design and good analytical features were obtained.
Magdalena Krawczyk; Henryk MatusiewiczHow to cite this article
In this study, the analytical potential of chemical vapor generation (CVG) and high-resolution continuum source atomic absorption spectrometry (CVG HR-CS AAS) with quartz tube atomization in the determination of gold was evaluated.
Fausto Carnevale Neto; Cristian D. Siquitelli; Alan C. Pilon; Dulce H. S. Silva; Vanderlan da S. Bolzani; Ian Castro-GamboaHow to cite this article
A rational and selective method using HPLC-ESI-QToF-MS/MS was developed for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The dereplicated metabolites were selected by previous in vitro DPPH assay. Seven flavanones and one benzophenone derivative were detected.
Sylvio V. Palombini; Swami A. Maruyama; Thiago Claus; Paula F. Montanher; Nilson E. de Souza; Jesuí V. Visentainer; Sandra Terezinha Marques Gomes; Makoto MatsushitaHow to cite this article
Legumes of Brazilian origin remain underexplored from the chemical point of view. Thus, this work was aimed at the antioxidant capacity determination of bean cultivars planted in different Brazilian regions through the employment of assays paired with the Quencher procedure. Their fatty acids were also quantified.
Aline K. Gohara; Aloisio H. P. Souza; Ângela C. Rodrigues; Gisely L. Stroher; Sandra T. M. Gomes; Nilson E. Souza; Jesuí V. Visentainer; Makoto MatsushitaHow to cite this article
Experimental design and principal component analysis (PCA) are important chemometric tools that were used to study the increase in mineral contents in cakes due to the use of azuki and chia flours. The response surface and PCA graphs are very useful in facilitating the visualization of the optimal region.
Anna Szymczycha-Madeja; Maja Welna; Wieslaw ZyrnickiHow to cite this article
The characteristic of macro (C, H, N, S, Ca, Mg, P) and micro (Al, Ba, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Sr, Ti, V) elements and investigations of organic matter in some herbal tea products (including infusions) using spectroscopic methods as well as bioavailabilities and fractionations of elements in teas were presented.
Emmanoel Vilaça Costa; Pedro Ernesto O. da Cruz; Maria Lúcia B. Pinheiro; Francisco A. Marques; Ana Lúcia T. G. Ruiz; Gabriela M. Marchetti; Joăo Ernesto de Carvalho; Andersson Barison; Beatriz Helena L. N. S. MaiaHow to cite this article
The phytochemical investigation of the leaves of Guatteria friesiana (Annonaceae) afforded three new isoquinoline alkaloids. Eight known alkaloids were also recovered, one of which was isolated as a natural product for the first time. The cytotoxic activity of the extracts, fractions and isolated compounds was evaluated against tumor cell lines.
Alessandra B. Ribeiro; Elton G. Bonafé; Beatriz C. Silva; Paula F. Montanher; Oscar O. Santos Júnior; Joana S. Boeing; Jesuí V. VisentainerHow to cite this article
Brazil is a country that has favorable geographical and climate characteristics for the production of edible fruits. In this study, the evaluation of exotic and native fruits from Brazil revealed the presence of antioxidant compounds and essential omega-3 and omega-6 fatty acids. Principal component analysis (PCA) helped to differentiate the fruit types.
Mirosław Gucma; W. Marek Gołębiewski; Maria KrawczykHow to cite this article
1,3-Dipolar cycloaddition of nitrile oxides to norbornenes substituted with an acrylate moiety occurs with a complete site-selectivity and exo selectivity.
Hülya Efe; Merve Bicen; Memet Vezir Kahraman; Nilhan Kayaman-ApohanHow to cite this article
The current study deals with the synthesis of 4-acryoylmorpholine (4-AcM) based hydrogels. Higher drug release was observed by increasing 4-AcM content, whereas the increase in crosslinking density due to PEG-DA content resulted in reduced diffusion of the drug.
Graciele S. Santana; Deborah P. Dick; Michely Tomazi; Cimélio Bayer; Aino V. A. JacquesHow to cite this article
Despite the complexity and heterogeneity of the soil organic matter (SOM), spectroscopic and thermogravimetric techniques have been effective tools to give information about its composition and the changes caused by soil use and management.
Valéria P. Barros; Marilda D. AssisHow to cite this article
This paper presents the oxidation of three azo dyes catalyzed by ironporphyrin. The products are resulted from the oxidation of the terminal amine, while the azo bond is left intact and similar products were verified in biological systems.
Giovana Maria L. Fiori; Pierina Sueli Bonato; Maria Paula Marques Pereira; Silvia Helena T. Contini; Ana Maria S. PereiraHow to cite this article
Development of an analytical method for identification and quantification of thymol and carvacrol in plasma and milk of cows after administration of an intra-mammary phytoformulation of veterinary use containing plant essential oils rich in thymol and carvacrol.
Willian T. Suarez; Osmundo D. Pessoa-Neto; Vagner B. dos Santos; Ana Rita de A. Nogueira; Ronaldo C. Faria; Orlando Fatibello-Filho; Julián A. ChamarroHow to cite this article
Photograph of a typical LTCC (low-temperature co-fired ceramic) device for microfluidic applications. The inlets are indicated by x, y and z, the outlet of the solutions by w and the optical flow cell by k. The cavities for coupling the brass tubes are also shown.
Gökhan Çimen; Şerife Tokalıoğlu; İsmail Özentürk; Cengiz SoykanHow to cite this article
The preparation of poly(N,N'-dipropionitrile methacrylamide-co-divinylbenzene-co-2-acrylamido-2-methyl-1-propanesulfonic acid) resin was carried out with a radical initiator in dimethylformamide solution.
Özgen Ercan; Adnan AydınHow to cite this article
1,3,5-Trithiane was used as a new adsorbent for removal of toxic metals such as mercury from wastewater. Adsorption isotherm models were applied to the experimental data
Eliane C. Vilela; Alessandra R. Duarte; Ronaldo V. Naves; Suzana C. Santos; José C. Seraphin; Pedro H. FerriHow to cite this article
Spatial chemometric methods based on fitted models using variograms and probability maps characterized the spatial chemical structure of E. dysenterica essential oil. These methods may contribute as additional tools to establish in situ conservation areas or sampling areas for ex situ conservation based only on oil chemovariations.
Hector H. F. Koolen; Laís S. Menezes; Mayane P. Souza; Felipe M. A. Silva; Fabiana G. O. Almeida; Antonia Q. L. de Souza; Angelita Nepel; Andersson Barison; Flávio Henrique da Silva; Danilo Elton Evangelista; Afonso D. L. de SouzaHow to cite this article
A novel dimeric xanthone related to the secalonic acids was isolated from the culture broth of Talaromyces sp., an endophytic fungus living in the healthy tissues of Duguetia stelechantha.
Rafaella R. A. Peixoto; Elaine A. M. Mazon; Solange CadoreHow to cite this article
The in vitro simulation of the human digestive process occurring in the mouth, stomach and intestine with the preparation of synthetic digestive fluids containing natural enzymes was studied. This model showed to be a good strategy to assess the bioaccessibility of metallic elements in chocolate drink powder (figure adapted from http://www.aboutgastro.com/digestive-system).
Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil