JBCS

1:56, Wed Nov 22

Open Access/APCs

vol. 24, No. 5, 2013, p. 707-890

 

Isatin, a Versatile Molecule: Studies in Brazil

Isatin was synthesised in 1840 before it was discovered in the nature. Its derivatives are found in the parotid gland secretions of the Bufo frog, in the egg masses of the Australian mollusc Dicathais orbita, in plants of the Isatis genus and in the species Couroupita guianensis, Aubl, Melochia tomentosa and Boronella koniamboensis. It is an important raw material for the synthesis of a wide spectrum of bioactive compounds. Its derivatives exhibit antiviral, anti-inflammatory, anticonvulsant and antitumor activities, among others. This account discusses studies performed by several Brazilian research groups, including the investigations of its structural changes, the design of biological assays and some novel synthesis routes. Details are presented in the Account Isatin, a Versatile Molecule: Studies in Brazil by Bárbara V. Silva on page 707.

(Read more at Editorial)


Cover Article
J. Braz. Chem. Soc. 2013, 24(5), 707-720

Isatin, a Versatile Molecule: Studies in Brazil

Bárbara V. Silva

How to cite this article

Isatin was synthesised in 1840 before it was discovered in the nature. Its derivatives are found in the parotid gland secretions of the Bufo frog, in the egg masses of the Australian mollusc Dicathais orbita, in plants of the Isatis genus and in the species Couroupita guianensis, Aubl, Melochia tomentosa and Boronella koniamboensis. It is an important raw material for the synthesis of a wide spectrum of bioactive compounds. Its derivatives exhibit antiviral, anti-inflammatory, anticonvulsant and antitumor activities, among others. This account discusses studies performed by several Brazilian research groups, including the investigations of its structural changes, the design of biological assays and some novel synthesis routes. Details are presented in the Account Isatin, a Versatile Molecule: Studies in Brazil by Bárbara V. Silva on page 707.

http://dx.doi.org/10.5935/0103-5053.20130089

Published online: April 10, 2013

Account J. Braz. Chem. Soc. 2013, 24(5), 707-720

Isatin, a Versatile Molecule: Studies in Brazil

Bárbara V. Silva

How to cite this article

 

Isatin is a small, versatile and widely applicable pharmacological molecule. Several Brazilian research groups have actively contributed to the development of novel synthetic routes to isatin derivatives, structural studies and the design of biological assays.

http://dx.doi.org/10.5935/0103-5053.20130089

Published online: April 10, 2013

Articles J. Braz. Chem. Soc. 2013, 24(5), 721-730

Adsorption and Release of Micronutrients by Humin Extracted from Peat Samples

Danielle Goveia; Camila de A. Melo; Lilian K. de Oliveira; Leonardo F. Fraceto; Julio Cesar Rocha; Newton Luiz Dias Filho; André Henrique Rosa

How to cite this article

 

Scheme of the analytical procedure used to determine the micronutrient adsorption/desorption capacity of humin extracted from peat samples. Conditions: ultrafiltration system (Sartorius Ultrasart X), 1 kDa polyethersulfone membrane (Gelman Pall-Filtron OMEGA).

http://dx.doi.org/10.5935/0103-5053.20130092

Published online: April 17, 2013

J. Braz. Chem. Soc. 2013, 24(5), 731-735

Use of Portable X-ray Fluorescence to Discriminate Brands of Nail Polishes: a Potential Forensic Tool

Gustavo G. Shimamoto; Juliana Terra; Maria Izabel M. S. Bueno

How to cite this article

 

The figure shows the steps to grouping nail polish samples depending on their brands to contribute as an useful evidence in forensic science. The proposed methodology is a quick, low cost and green alternative.

http://dx.doi.org/10.5935/0103-5053.20130093

Published online: April 17, 2013

J. Braz. Chem. Soc. 2013, 24(5), 736-742

FAAS Determination of Ag(I) in Water, Anode Slime, Rock and Cream Samples by Solid Phase Extraction Method based on Sepabeads SP207/5-(p-Dimethylaminobenzylidene) Rhodanine Combination

Emre Yavuz; Şerife Tokalıoğlu; Serkan Şahan

How to cite this article

 

5-(p-Dimethylaminobenzylidene) rhodanine (PDR) is a derivative of rhodanine that is especially suitable as a sensitive and highly selective reagent for silver. It forms slightly soluble red precipitate with Ag(I).

http://dx.doi.org/10.5935/0103-5053.20130094

Published online: April 17, 2013


J. Braz. Chem. Soc. 2013, 24(5), 743-748

Integrated Pressurized Solvent Extraction-Cleanup for the Rapid Determination of Polychlorinated Biphenyls in Meat Samples

Carla Toledo-Neira; Pedro Enríquez; Pablo Richter

How to cite this article

 

Integrated Pressurized liquid extraction (PLE) with solid phase extraction (SPE) cleanup method was developed for determination of polychlorinated biphenyls in chicken and pork meat samples. Extraction variables were optimized by experimental design and good analytical features were obtained.

http://dx.doi.org/10.5935/0103-5053.20130095

Published online: April 19, 2013

J. Braz. Chem. Soc. 2013, 24(5), 749-757

Determination of Gold by High-Resolution Continuum Source Atomic Absorption Spectrometry with Chemical Vapor Generation

Magdalena Krawczyk; Henryk Matusiewicz

How to cite this article

 

In this study, the analytical potential of chemical vapor generation (CVG) and high-resolution continuum source atomic absorption spectrometry (CVG HR-CS AAS) with quartz tube atomization in the determination of gold was evaluated.

http://dx.doi.org/10.5935/0103-5053.20130096

Published online: April 19, 2013

J. Braz. Chem. Soc. 2013, 24(5), 758-764

Dereplication of Phenolic Derivatives of Qualea grandiflora and Qualea cordata (Vochysiaceae) using Liquid Chromatography coupled with ESI-QToF-MS/MS

Fausto Carnevale Neto; Cristian D. Siquitelli; Alan C. Pilon; Dulce H. S. Silva; Vanderlan da S. Bolzani; Ian Castro-Gamboa

How to cite this article

 

A rational and selective method using HPLC-ESI-QToF-MS/MS was developed for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The dereplicated metabolites were selected by previous in vitro DPPH assay. Seven flavanones and one benzophenone derivative were detected.

http://dx.doi.org/10.5935/0103-5053.20130098

Published online: April 24, 2013


J. Braz. Chem. Soc. 2013, 24(5), 765-770

Antioxidant Activity of Brazilian Bean Cultivars

Sylvio V. Palombini; Swami A. Maruyama; Thiago Claus; Paula F. Montanher; Nilson E. de Souza; Jesuí V. Visentainer; Sandra Terezinha Marques Gomes; Makoto Matsushita

How to cite this article

 

Legumes of Brazilian origin remain underexplored from the chemical point of view. Thus, this work was aimed at the antioxidant capacity determination of bean cultivars planted in different Brazilian regions through the employment of assays paired with the Quencher procedure. Their fatty acids were also quantified.

http://dx.doi.org/10.5935/0103-5053.20130100

Published online: April 26, 2013

J. Braz. Chem. Soc. 2013, 24(5), 771-776

Chemometric Methods Applied to the Mineral Content Increase in Chocolate Cakes Containing Chia and Azuki

Aline K. Gohara; Aloisio H. P. Souza; Ângela C. Rodrigues; Gisely L. Stroher; Sandra T. M. Gomes; Nilson E. Souza; Jesuí V. Visentainer; Makoto Matsushita

How to cite this article

 

Experimental design and principal component analysis (PCA) are important chemometric tools that were used to study the increase in mineral contents in cakes due to the use of azuki and chia flours. The response surface and PCA graphs are very useful in facilitating the visualization of the optimal region.

http://dx.doi.org/10.5935/0103-5053.20130101

Published online: April 26, 2013

J. Braz. Chem. Soc. 2013, 24(5), 777-787

Multi-Element Analysis, Bioavailability and Fractionation of Herbal Tea Products

Anna Szymczycha-Madeja; Maja Welna; Wieslaw Zyrnicki

How to cite this article

 

The characteristic of macro (C, H, N, S, Ca, Mg, P) and micro (Al, Ba, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Sr, Ti, V) elements and investigations of organic matter in some herbal tea products (including infusions) using spectroscopic methods as well as bioavailabilities and fractionations of elements in teas were presented.

http://dx.doi.org/10.5935/0103-5053.20130102

Published online: April 26, 2013

J. Braz. Chem. Soc. 2013, 24(5), 788-796

Aporphine and Tetrahydroprotoberberine Alkaloids from the Leaves of Guatteria friesiana (Annonaceae) and their Cytotoxic Activities

Emmanoel Vilaça Costa; Pedro Ernesto O. da Cruz; Maria Lúcia B. Pinheiro; Francisco A. Marques; Ana Lúcia T. G. Ruiz; Gabriela M. Marchetti; Joăo Ernesto de Carvalho; Andersson Barison; Beatriz Helena L. N. S. Maia

How to cite this article

 

The phytochemical investigation of the leaves of Guatteria friesiana (Annonaceae) afforded three new isoquinoline alkaloids. Eight known alkaloids were also recovered, one of which was isolated as a natural product for the first time. The cytotoxic activity of the extracts, fractions and isolated compounds was evaluated against tumor cell lines.

http://dx.doi.org/10.5935/0103-5053.20130103

Published online: April 30, 2013


J. Braz. Chem. Soc. 2013, 24(5), 797-804

Antioxidant Capacity, Total Phenolic Content, Fatty Acids and Correlation by Principal Component Analysis of Exotic and Native Fruits from Brazil

Alessandra B. Ribeiro; Elton G. Bonafé; Beatriz C. Silva; Paula F. Montanher; Oscar O. Santos Júnior; Joana S. Boeing; Jesuí V. Visentainer

How to cite this article

 

Brazil is a country that has favorable geographical and climate characteristics for the production of edible fruits. In this study, the evaluation of exotic and native fruits from Brazil revealed the presence of antioxidant compounds and essential omega-3 and omega-6 fatty acids. Principal component analysis (PCA) helped to differentiate the fruit types.

http://dx.doi.org/10.5935/0103-5053.20130105

Published online: May 3, 2013

J. Braz. Chem. Soc. 2013, 24(5), 805-813

NMR Studies on 1,3-Dipolar Cycloaddition of Nitrile Oxides to Norbornenes

Mirosław Gucma; W. Marek Gołębiewski; Maria Krawczyk

How to cite this article

 

1,3-Dipolar cycloaddition of nitrile oxides to norbornenes substituted with an acrylate moiety occurs with a complete site-selectivity and exo selectivity.

http://dx.doi.org/10.5935/0103-5053.20130106

Published online: May 3, 2013


J. Braz. Chem. Soc. 2013, 24(5), 814-820

Synthesis of 4-Acryloylmorpholine-based Hydrogels and Investigation of their Drug Release Behaviors

Hülya Efe; Merve Bicen; Memet Vezir Kahraman; Nilhan Kayaman-Apohan

How to cite this article

 

The current study deals with the synthesis of 4-acryoylmorpholine (4-AcM) based hydrogels. Higher drug release was observed by increasing 4-AcM content, whereas the increase in crosslinking density due to PEG-DA content resulted in reduced diffusion of the drug.

http://dx.doi.org/10.5935/0103-5053.20130107

Published online: May 8, 2013

J. Braz. Chem. Soc. 2013, 24(5), 821-829

Chemical Composition and Stocks of Soil Organic Matter in a South Brazilian Oxisol under Pasture

Graciele S. Santana; Deborah P. Dick; Michely Tomazi; Cimélio Bayer; Aino V. A. Jacques

How to cite this article

 

Despite the complexity and heterogeneity of the soil organic matter (SOM), spectroscopic and thermogravimetric techniques have been effective tools to give information about its composition and the changes caused by soil use and management.

http://dx.doi.org/10.5935/0103-5053.20130108

Published online: May 8, 2013

J. Braz. Chem. Soc. 2013, 24(5), 830-836

Iron Porphyrins as Biomimetical Models for Disperse Azo Dye Oxidation

Valéria P. Barros; Marilda D. Assis

How to cite this article

 

This paper presents the oxidation of three azo dyes catalyzed by ironporphyrin. The products are resulted from the oxidation of the terminal amine, while the azo bond is left intact and similar products were verified in biological systems.

http://dx.doi.org/10.5935/0103-5053.20130110

Published online: May 10, 2013


J. Braz. Chem. Soc. 2013, 24(5), 837-846

Determination of Thymol and Carvacrol in Plasma and Milk of Dairy Cows using Solid-Phase Microextraction

Giovana Maria L. Fiori; Pierina Sueli Bonato; Maria Paula Marques Pereira; Silvia Helena T. Contini; Ana Maria S. Pereira

How to cite this article

 

Development of an analytical method for identification and quantification of thymol and carvacrol in plasma and milk of cows after administration of an intra-mammary phytoformulation of veterinary use containing plant essential oils rich in thymol and carvacrol.

http://dx.doi.org/10.5935/0103-5053.20130109

Published online: May 10, 2013

J. Braz. Chem. Soc. 2013, 24(5), 847-855

A Compact Miniaturized Flow System Based on Low-Temperature Co-fired Ceramic Technology Coupled to LED Mini-photometer for Determination of Dipyrone in Pharmaceutical Formulations

Willian T. Suarez; Osmundo D. Pessoa-Neto; Vagner B. dos Santos; Ana Rita de A. Nogueira; Ronaldo C. Faria; Orlando Fatibello-Filho; Julián A. Chamarro

How to cite this article

 

Photograph of a typical LTCC (low-temperature co-fired ceramic) device for microfluidic applications. The inlets are indicated by x, y and z, the outlet of the solutions by w and the optical flow cell by k. The cavities for coupling the brass tubes are also shown.

http://dx.doi.org/10.5935/0103-5053.20130112

Published online: May 15, 2013


J. Braz. Chem. Soc. 2013, 24(5), 856-864

Speciation and Preconcentration of Chromium from Water and Food Samples by Synthesized Chelating Resin

Gökhan Çimen; Şerife Tokalıoğlu; İsmail Özentürk; Cengiz Soykan

How to cite this article

 

The preparation of poly(N,N'-dipropionitrile methacrylamide-co-divinylbenzene-co-2-acrylamido-2-methyl-1-propanesulfonic acid) resin was carried out with a radical initiator in dimethylformamide solution.

http://dx.doi.org/10.5935/0103-5053.20130113

Published online: May 15, 2013


J. Braz. Chem. Soc. 2013, 24(5), 865-872

Removal of Mercury, Antimony, Cadmium and Lead from Aqueous Solution using 1,3,5-Trithiane as an Adsorbent

Özgen Ercan; Adnan Aydın

How to cite this article

 

1,3,5-Trithiane was used as a new adsorbent for removal of toxic metals such as mercury from wastewater. Adsorption isotherm models were applied to the experimental data

http://dx.doi.org/10.5935/0103-5053.20130114

Published online: May 17, 2013

Short Report J. Braz. Chem. Soc. 2013, 24(5), 873-879

Spatial Chemometric Analyses of Essential Oil Variability in Eugenia dysenterica

Eliane C. Vilela; Alessandra R. Duarte; Ronaldo V. Naves; Suzana C. Santos; José C. Seraphin; Pedro H. Ferri

How to cite this article

 

Spatial chemometric methods based on fitted models using variograms and probability maps characterized the spatial chemical structure of E. dysenterica essential oil. These methods may contribute as additional tools to establish in situ conservation areas or sampling areas for ex situ conservation based only on oil chemovariations.

http://dx.doi.org/10.5935/0103-5053.20130099

Published online: April 24, 2013


J. Braz. Chem. Soc. 2013, 24(5), 880-883

Talaroxanthone, a Novel Xanthone Dimer from the Endophytic Fungus Talaromyces sp. Associated with Duguetia stelechantha (Diels) R. E. Fries

Hector H. F. Koolen; Laís S. Menezes; Mayane P. Souza; Felipe M. A. Silva; Fabiana G. O. Almeida; Antonia Q. L. de Souza; Angelita Nepel; Andersson Barison; Flávio Henrique da Silva; Danilo Elton Evangelista; Afonso D. L. de Souza

How to cite this article

 

A novel dimeric xanthone related to the secalonic acids was isolated from the culture broth of Talaromyces sp., an endophytic fungus living in the healthy tissues of Duguetia stelechantha.

http://dx.doi.org/10.5935/0103-5053.20130104

Published online: April 30, 2013


J. Braz. Chem. Soc. 2013, 24(5), 884-890

Estimation of the Bioaccessibility of Metallic Elements in Chocolate Drink Powder using an in vitro Digestion Method and Spectrometric Techniques

Rafaella R. A. Peixoto; Elaine A. M. Mazon; Solange Cadore

How to cite this article

 

The in vitro simulation of the human digestive process occurring in the mouth, stomach and intestine with the preparation of synthetic digestive fluids containing natural enzymes was studied. This model showed to be a good strategy to assess the bioaccessibility of metallic elements in chocolate drink powder (figure adapted from http://www.aboutgastro.com/digestive-system).

http://dx.doi.org/10.5935/0103-5053.20130111

Published online: May 10, 2013

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil

Tel/Fax: +55.19.3521.3151
Free access

GN1