JBCS

Isatin is a small, versatile and widely applicable pharmacological molecule. Several Brazilian research groups have actively contributed to the development of novel synthetic routes to isatin derivatives, structural studies and the design of biological assays.

Scheme of the analytical procedure used to determine the micronutrient adsorption/desorption capacity of humin extracted from peat samples. Conditions: ultrafiltration system (Sartorius Ultrasart X), 1 kDa polyethersulfone membrane (Gelman Pall-Filtron OMEGA).

The figure shows the steps to grouping nail polish samples depending on their brands to contribute as an useful evidence in forensic science. The proposed methodology is a quick, low cost and green alternative.

5-(p-Dimethylaminobenzylidene) rhodanine (PDR) is a derivative of rhodanine that is especially suitable as a sensitive and highly selective reagent for silver. It forms slightly soluble red precipitate with Ag(I).

Integrated Pressurized liquid extraction (PLE) with solid phase extraction (SPE) cleanup method was developed for determination of polychlorinated biphenyls in chicken and pork meat samples. Extraction variables were optimized by experimental design and good analytical features were obtained.

In this study, the analytical potential of chemical vapor generation (CVG) and high-resolution continuum source atomic absorption spectrometry (CVG HR-CS AAS) with quartz tube atomization in the determination of gold was evaluated.

A rational and selective method using HPLC-ESI-QToF-MS/MS was developed for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The dereplicated metabolites were selected by previous in vitro DPPH assay. Seven flavanones and one benzophenone derivative were detected.

Legumes of Brazilian origin remain underexplored from the chemical point of view. Thus, this work was aimed at the antioxidant capacity determination of bean cultivars planted in different Brazilian regions through the employment of assays paired with the Quencher procedure. Their fatty acids were also quantified.

Experimental design and principal component analysis (PCA) are important chemometric tools that were used to study the increase in mineral contents in cakes due to the use of azuki and chia flours. The response surface and PCA graphs are very useful in facilitating the visualization of the optimal region.

The characteristic of macro (C, H, N, S, Ca, Mg, P) and micro (Al, Ba, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Sr, Ti, V) elements and investigations of organic matter in some herbal tea products (including infusions) using spectroscopic methods as well as bioavailabilities and fractionations of elements in teas were presented.

The phytochemical investigation of the leaves of Guatteria friesiana (Annonaceae) afforded three new isoquinoline alkaloids. Eight known alkaloids were also recovered, one of which was isolated as a natural product for the first time. The cytotoxic activity of the extracts, fractions and isolated compounds was evaluated against tumor cell lines.

Brazil is a country that has favorable geographical and climate characteristics for the production of edible fruits. In this study, the evaluation of exotic and native fruits from Brazil revealed the presence of antioxidant compounds and essential omega-3 and omega-6 fatty acids. Principal component analysis (PCA) helped to differentiate the fruit types.

1,3-Dipolar cycloaddition of nitrile oxides to norbornenes substituted with an acrylate moiety occurs with a complete site-selectivity and exo selectivity.

The current study deals with the synthesis of 4-acryoylmorpholine (4-AcM) based hydrogels. Higher drug release was observed by increasing 4-AcM content, whereas the increase in crosslinking density due to PEG-DA content resulted in reduced diffusion of the drug.

Despite the complexity and heterogeneity of the soil organic matter (SOM), spectroscopic and thermogravimetric techniques have been effective tools to give information about its composition and the changes caused by soil use and management.

This paper presents the oxidation of three azo dyes catalyzed by ironporphyrin. The products are resulted from the oxidation of the terminal amine, while the azo bond is left intact and similar products were verified in biological systems.

Development of an analytical method for identification and quantification of thymol and carvacrol in plasma and milk of cows after administration of an intra-mammary phytoformulation of veterinary use containing plant essential oils rich in thymol and carvacrol.

Photograph of a typical LTCC (low-temperature co-fired ceramic) device for microfluidic applications. The inlets are indicated by x, y and z, the outlet of the solutions by w and the optical flow cell by k. The cavities for coupling the brass tubes are also shown.

The preparation of poly(N,N'-dipropionitrile methacrylamide-co-divinylbenzene-co-2-acrylamido-2-methyl-1-propanesulfonic acid) resin was carried out with a radical initiator in dimethylformamide solution.

1,3,5-Trithiane was used as a new adsorbent for removal of toxic metals such as mercury from wastewater. Adsorption isotherm models were applied to the experimental data

Spatial chemometric methods based on fitted models using variograms and probability maps characterized the spatial chemical structure of E. dysenterica essential oil. These methods may contribute as additional tools to establish in situ conservation areas or sampling areas for ex situ conservation based only on oil chemovariations.

A novel dimeric xanthone related to the secalonic acids was isolated from the culture broth of Talaromyces sp., an endophytic fungus living in the healthy tissues of Duguetia stelechantha.

The in vitro simulation of the human digestive process occurring in the mouth, stomach and intestine with the preparation of synthetic digestive fluids containing natural enzymes was studied. This model showed to be a good strategy to assess the bioaccessibility of metallic elements in chocolate drink powder (figure adapted from http://www.aboutgastro.com/digestive-system).