Recent Papers - Machine Learning Special Issue
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Several studies have reported the anticarcinogenic activity of conjugated linoleic acid (CLA) naturally found in the meat of ruminants (cattle, goats, and sheep) and in dairy products. The anticarcinogenic effect of the cis-9, trans-11 isomer of CLA was studied using two breast cancer (BC) cell lines, one positive (MCF-7) and the other negative (MDA-MB-231) for estrogen receptors. The nuclear magnetic resonance (NMR) metabolomics studies of intact BC cells demonstrate that CLA reduces the level of phosphocholine, a BC malignancy biomarker, in both cell lines. CLA also strongly interferes in acetone metabolism, mainly in the MCF-7 cell line, indicating an effect on fatty acid metabolism. Details are presented in the Communication Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy by Roberta M. Maria, Wanessa F. Altei, Napoleao F. Valadares, Richard C. Garratt, Adriano D. Andricopulo, Tiago Venâncio and Luiz A. Colnago on page 3.
Roberta M. Maria ; Wanessa F. Altei; Napoleao F. Valadares; Richard C. Garratt; Adriano D. Andricopulo; Tiago Venâncio; Luiz A. Colnago
Several studies have reported the anticarcinogenic activity of conjugated linoleic acid (CLA) naturally found in the meat of ruminants (cattle, goats, and sheep) and in dairy products. The anticarcinogenic effect of the cis-9, trans-11 isomer of CLA was studied using two breast cancer (BC) cell lines, one positive (MCF-7) and the other negative (MDA-MB-231) for estrogen receptors. The nuclear magnetic resonance (NMR) metabolomics studies of intact BC cells demonstrate that CLA reduces the level of phosphocholine, a BC malignancy biomarker, in both cell lines. CLA also strongly interferes in acetone metabolism, mainly in the MCF-7 cell line, indicating an effect on fatty acid metabolism. Details are presented in the Communication Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by 1H HR-MAS NMR Spectroscopy by Roberta M. Maria, Wanessa F. Altei, Napoleao F. Valadares, Richard C. Garratt, Adriano D. Andricopulo, Tiago Venâncio and Luiz A. Colnago on page 3.
Roberta M. Maria ; Wanessa F. Altei; Napoleao F. Valadares; Richard C. Garratt; Adriano D. Andricopulo; Tiago Venâncio; Luiz A. Colnago
The effects of cis-9, trans-11 conjugated linoleic acid (CLA) on the metabolic profile of MCF-7 and MDA-MB-231 breast cancer cells were evaluated using high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy.
Cibelle C. David; Antonio C. S. Lins; Tania M. S. Silva; Júlia F. Campos; Teresinha G. Silva; Gardenia C. G. Militao; Celso A. Camara
An efficient Knoevenagel condensation between aldehydes and lawsone was performed under new conditions showing good isolated yields in a short reaction time and simple conditions.
Luisa L. Marçal; Simon J. Garden
Substrate face controlled concerted oxidative rearrangement of N-acyltetrahydro-β-carbolines stereoselectively gives spiropyrrolidinyloxindoles.
André L. P. G. Lourenço; Percilene F. Vegi; Jéssica V. Faria; Gustavo S. P. Pinto; Maurício S. dos Santos ; Plínio C. Sathler; Max S. Saito; Marcos Santana; Tatiana P. P. Dutra; Carlos R. Rodrigues; Robson Q. Monteiro; Alice M. R. Bernardino; Helena C. Castro
Fourteen pyrazole compounds were synthesized and evaluated with regard to anticoagulant and antithrombotic activities. These derivatives were investigated through an integrated multiplex analysis virtual screening (IMA-VS) pipeline.
Caroline F. Grecco; Israel D. Souza; Vinicius R. Acquaro Junior; Maria E. C. Queiroz
Determination of parabens in breast milk samples by dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS).
Nayara A. dos Santos; Lilian V. Tose; Samantha R. C. da Silva; Michael Murgu; Ricardo M. Kuster; Rafael S. Ortiz; Flavio A. O. Camargo; Boniek G. Vaz; Valdemar Lacerda Jr. ; Wanderson Romao
Analysis of cannabinoid standards by ultra performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UPLC-ESI-QTOF-MS) and UPLC-ESI-travelling wave ion mobility (TWIM)-MS.
Sergiane S. Caldas; Jean Lucas O. Arias ; Caroline Rombaldi; Lucas L. Mello; Maristela B. R. Cerqueira; Ayrton F. Martins; Ednei G. Primel
Fifty-one compounds including PPCPs and pesticides were monitored from 2011 to 2014 in drinking and surface waters in Rio Grande do Sul State.
Rafaela G. M. da Costa; Francisco R. L. Farias; Luis Maqueira; Carlos Castanho Neto; Leonardo S. A. Carneiro; Joseany M. S. Almeida; Camilla D. Buarque; Ricardo Q. Aucélio; Jones Limberger
A series of triphenylamino (TPA)-chalcones and β-arylchalcones, displaying either D-π-D or D-π-A architecture, were synthesized and characterized. Photophysical and electrochemical properties of these compounds were evaluated.
Letícia T. Chendynski; Érica S. Romagnoli; Ana Carolina G. Mantovani; Marissa Kimura; Leonardo C. Marques; Dionisio Borsato
Influence of copper and metallic alloys on the biodiesel oxidation reaction.
Maria C. F. Dias; Thiago Q. Gularte; Róbson R. Teixeira ; Jorge A. N. Santos; Eduardo J. Pilau
; Tiago A. O. Mendes; Antônio J. Demuner; Marcelo H. dos Santos
The conversion of 4,4'-dihydroxybenzophenone into a series of 1,2,3-triazolic derivatives resulted in the identification of bis(4-(1-(4-iodobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)benzophenone with significant elastase inhibitory activity (IC50 = 16.6 ± 1.9 µM, inhibition constant (Ki) of 11.12 µM).
Thais T. Mingroni; Juliana Hamada; Alexsandra D. S. Xavier; Cleusa Cavalcante; Angerson N. do Nascimento
An in vitro evaluation of Ca, Cu, and Mg bioaccessibility in fresh and dried fruits was carried out, with results demonstrating that the dehydration process negatively affects bioaccessibility of Ca and Mg in dried fruits.
Manuel Pastrana Restrepo ; Verónica Surmay Surmay; Elkin Galeano Jaramillo; Sara Robledo Restrepo
Novel 3,5-diiodophenethyl-benzamides as new lead compounds for the development of new anti-parasites treatment.
Isabel Monreal; Mariano Sánchez-Castellanos; Karla Ramírez‑Gualito; Gabriel Cuevas; Karla A. Espinoza; Ignacio A. Rivero
The quinazolinones showed a large range diastereotopic effect that was studied through nuclear magnetic resonance (NMR) and computational calculations.
Daiane B. M. Lima; Anaí L. dos Santos; Ariel O. Celestino; Nayna Sampaio; Jéssica Baldez; Maria I. S. Melecchi; Thiago R. Bjerk; Laíza C. Krause; Elina B. Caramao
Sonication extraction from leaves and fruits using response surface methodology and analysis of the extracts by gas chromatography-mass spectrometry (GC-MS) showing as major compounds: octanoic acid, vitamin E, phytol and hydroxymethylfurfural.
Thábata L. A. B. Nascimento; Tiago L. S. Coelho; Cícero A. Lopes Júnior; Samuel A. A. Sousa; Herbert S. Barbosa
Optimization of sample preparation procedure in the extraction of cowpea proteins using the high-performance liquid chromatography (HPLC) technique as a comparative tool.
Valéria B. Riatto ; Mauricio M. Victor; Jaqueline F. Sousa; Carla Menegola
This work describes the first use of marine sponge Cliona varians as biocatalytic agents in the stereoselective reduction of α-keto esters and isatin.
Alicia A. Romero-Frías ; Diana C. Sinuco; José Maurício S. Bento
Volatile organic compounds released by Heilipus lauri (Coleoptera: Curculionidae).
Raíssa K. C. de Paiva; Jamerson F. da Silva; Hudieyllen A. Moreira; Osvaldo G. Pinto; Lilian T. F. M. Camargo; Plínio L. F. Naves; Ademir J. Camargo; Luciano Ribeiro; Luciana M. Ramos
The synthesis and antimicrobial activity of thiazolidine-2,4-dione derivatives are described. The structures of the synthesized compounds were confirmed by infrared and nuclear magnetic resonance. All compounds were evaluated for their in vitro antibacterial activity. Density functional theory and principal component analysis were used to discriminate the compounds.
Fernando Ratuchne; Ana C. Mora; Ricardo Celeste; Albérico B. F. da Silva
The polarization exponents (αw) vary with the atomic number (Z) for a sequence of atoms in a row with the same valence structure. Thus, αw can be obtained by interpolation.
Sandro Navickiene ; Luis F. S. Santos; Mônica C. Santos; Alain Gaujac
Evaluation of efficiency of coconut charcoal and menthone-thiosemicarbazone as alternative solid phase extraction adsorbent for the determination of alkaloids in ayahuasca beverage.
Helivaldo D. S. Souza; Roxana P. F. de Sousa; Bruno F. Lira; Raquel F. Vilela; Nathalie H. P. B. Borges; José P. de Siqueira‑Junior; Edeltrudes O. Lima; Jeane U. G. Jardim; Gracielle A. T. da Silva; José M. Barbosa‑Filho; Petrônio F. de Athayde‑Filho
The organoselenium compounds presented are prominent in medicinal chemistry; due to the increase of resistant fungi and bacteria, novel organoselenium compounds have been investigated as potent antimicrobials.
Iara S. Santos; Fabiana S. Guerra; Lucas F. Bernardino; Patrícia D. Fernandes; Lidilhone Hamerski; Bárbara V. Silva
It was synthesized a new isatinspirooxazine derivative with an half maximal inhibitory concentration (IC50) = 0.34 µM, more potent than the reference drug, doxorubicin (IC50 = 1.88 µM), in breast cancer line MDA-MB231.
Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil
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