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Cyclic imides have a wide range of important biological activities, which include anticancer, analgesic, antibacterial and antifungal activities. The synthesized compounds were obtained from safrole and showed antifungal activity against Candida and Cryptococcus strains. A conformational study was carried out, attributing the stereochemistry of one of the compounds. Details are presented in the Article Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole by Raquel F. Vilela, Normando A. S. Costa, Helivaldo D. S. Souza, Luiz E. G. Cruz, Kelyonara M. S. de Assis, Edeltrudes O. Lima, Laísa V. Cordeiro, Bruno F. Lira, Petronio F. de Athayde-Filho, Gerd B. Rocha and José M. Barbosa-Filho on page 2091.
Raquel F. Vilela; Normando A. S. Costa; Helivaldo D. S. Souza ; Luiz E. G. Cruz; Kelyonara M. S. de Assis; Edeltrudes O. Lima; Laísa V. Cordeiro; Bruno F. Lira; Petronio F. de Athayde-Filho; Gerd B. Rocha; José M. Barbosa-Filho
How to cite this articleCyclic imides have a wide range of important biological activities, which include anticancer, analgesic, antibacterial and antifungal activities. The synthesized compounds were obtained from safrole and showed antifungal activity against Candida and Cryptococcus strains. A conformational study was carried out, attributing the stereochemistry of one of the compounds. Details are presented in the Article Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole by Raquel F. Vilela, Normando A. S. Costa, Helivaldo D. S. Souza, Luiz E. G. Cruz, Kelyonara M. S. de Assis, Edeltrudes O. Lima, Laísa V. Cordeiro, Bruno F. Lira, Petronio F. de Athayde-Filho, Gerd B. Rocha and José M. Barbosa-Filho on page 2091.
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The chemists from Latin-America need to do more to achieve equality in the scientific world and gain greater recognition by the broader chemical community. For this, we should rethink our strategy to fight for a more inclusive science, not only internationally but also within our region. Raise your hands and take actions to support this movement. The content of this Letter appears as Editorial jointly published in the American Chemical Society journals Organic Letters, The Journal of Organic Chemistry, Organometallics , and Inorganic Chemistry.
Alex S. Torquato; Paulo R. S. Bittencourt ; Fernando R. Scremin; Rosana A. da Silva-Buzanello; Thays R. Gonçalves; Makoto Matsushita
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The chemical reactions accompanying any thermal treatment of soybean oil or palm olein must be carefully monitored in the food industries, to ensure the quality and healthiness of processed foods.
Ariele C. Moreira; Renato L. Carneiro; Mariana F. Fracola; Kelli C. Micocci; Odair C. Bueno; Dulce H. F. Souza
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Analysis of the chitin synthase expression during Atta sexdens developmental stages.
Mariane B. R. de Ávila; Lêda R. A. Faroni; Fernanda F. Heleno; Maria Eliana L. R. de Queiroz ; Rodrigo I. Almeida
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It was studied the dissipation of insecticides residues in rice and the translocation of these insecticide residues in husked rice for 35 days. For that, the solid-liquid extraction methods with low temperature partition (SLE/LTP) method followed by gas chromatography with electron capture detection (GC-ECD) for unhulled and husked rice were optimized and validated.
Josane C. de Jesus; Grazielly J. Silva; Ben-Hur R. F. Gonçalves; Marcelo R. de Souza; Leandro S. Santos; Sibelli P. B. Ferrão
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Use of Fourier transform infrared spectroscopy combined with multivariate analysis to identify the maturation time of Minas artisanal cheese.
Taís Felix ; Luís O. B. Benetoli; Susana Sério; Marta E. R. Dotto; Nito A. Debacher
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Polymeric samples were exposed to non-thermal plasma, and roughness patterns were formed as a function of time. After extensive statistical analysis, it was observed that the patterns were repeated, and growth models could be proposed.
Jhéssica C. S. Golveia ; Maria Teresa F. Bara ; Mariângela F. Santiago ; Luiza C. Campos ; Fernando Schimidt
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Biodegradation of 17-α-ethinylestradiol with laccase from fungi, using cocoa agro-industrial residue as inductor replacing the xylidine.
Arthur L. Macedo ; Lucas H. Martorano ; Ana Carolina F. de Albuquerque; Rodolfo G. Fiorot ; José W. M. Carneiro ; Vinicius R. Campos ; Thatyana R. A. Vasconcelos ; Alessandra L. Valverde ; Davyson L. Moreira ; Fernando M. dos Santos Jr.
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Determination of the absolute configuration of (−)-cubebin by means of a robust combination of theoretical and experimental methods.
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Marco A. G. Valente Jr. ; Luís M. Gonçalves ; Juliano Passaretti Filho; Arnaldo A. Cardoso; José A. Rodrigues; Cecilio S. Fugivara; Assis V. Benedetti
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A new methodology involving the gas diffusion microextraction was used for the analysis of volatile corrosion inhibitors. The inhibition efficiencies were evaluated by mass loss measurements using deliquescence NaCl crystal test.
Ariane C. Ribicki; Mayara L. Sperandio; Viviane J. Van Haandel; Ruben A. Estrada; Sérgio T. Fujiwara
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Possible mechanisms involved in Cu2+, Cd2+ and Ni2+ adsorption on 3-n-propylimidazolium silsesquioxane chloride (SiImi+Cl-).
Ichraf Slimani; Ahlem Chakchouk-Mtibaa; Lotfi Mellouli; Lamjed Mansour; Ismail Ozdemir; Nevin Gürbüz; Naceur Hamdi
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In this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j) and their AgI complexes (3a-3j).
Xiaosheng Tang; Aiping Xiao; Shiyong Mei; Ping Tang; Licheng Ren; Liangliang Liu
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Four screened xanthine oxidase inhibitors could effectively enhance cell viability and protect injury of gastric epithelial cell lines (GES-1 cells) from oxidative stress.
Raimundo R. Gamela; Vinicius C. Costa; Matheus L. de Mello; Julia C. Romero; Fábio A. C. Amorim ; Edenir R. Pereira-Filho
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Cocoa beans analysis for the determination of inorganic constituents using inductively coupled plasma optical emission spectrometry (ICP OES) and previous sample preparation optimization employing multivariate analysis.
Raquel F. Vilela; Normando A. S. Costa; Helivaldo D. S. Souza ; Luiz E. G. Cruz; Kelyonara M. S. de Assis; Edeltrudes O. Lima; Laísa V. Cordeiro; Bruno F. Lira; Petronio F. de Athayde-Filho; Gerd B. Rocha; José M. Barbosa-Filho
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Starting from safrole, after three steps, we obtained cyclic imides with antifungal activity with minimum inhibitory concentration (MIC) of 0.17 µmol mL-1.
Jéssica O. Costa; Rodolfo S. Barboza ; Ligia M. M. Valente ; Thiago Wolff ; Mário Gomes ; Blanca Gallo; Luis A. Berrueta ; Iris P. Guimarães-Andrade; Daniel Gavino-Leopoldino; Iranaia Assunção-Miranda
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Three anti-dengue active monoterpene indole alkaloids were isolated in just one-step directly from the leaf MeOH extract of Psychotria leiocarpa.
Anderson A. V. Pinheiro ; Renata P. C. Barros; Edileuza B. de Assis; Mayara S. Maia; Diego I. A. F. de Araújo; Kaio A. Sales; Luciana Scotti ; Josean F. Tavares ; Marcus T. Scotti ; Marcelo S. da Silva
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Virtual screening of a Velloziaceae family bank against Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Salmonella sp., using computational tools.
Dandan Ge ; Ying Gao; Yunxin Cao; Enrui Dai; Lin Yuan
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A polymeric deep eutectic solvent composed of DL-menthol and polyethylene glycol 400 was prepared and used as extraction solvent in vortex-assisted liquid-liquid microextraction method combined with high performance liquid chromatography-diode array detector for the determination of parabens.
Dayanne M. Bordin; Samara G. C. Latgé; Graham Pyke; John Kalman; Philip Doble; Fernando A. Genta; Lucas Blanes
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Illustration of the separation of the three main sugars found in nectar samples: fructose, glucose and sucrose by capillary electrophoresis.
Mariacaterina Lianza; Maria Helena Verdan; Jean Paulo de Andrade; Ferruccio Poli; Larissa C. de Almeida; Leticia V. Costa-Lotufo; Álvaro Cunha Neto; Sarah C. C. Oliveira; Jaume Bastida; Andrea N. L. Batista; João M. Batista Jr. ; Warley S. Borges
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Cytotoxic isoquinoline alkaloids were isolated from Hippeastrum goianum and had their absolute configurations determined by using vibrational circular dichroism (VCD).
Matheus Gallimberti; Bruno A. Rocha ; Vanessa C. O. Souza; Andres D. Campiglia; Fernando Barbosa Jr
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Fast determination of bisphenol A in paper samples and estimation of exposure via handling papers.
Yan Chen ; Yong Fang; Jinglong Pan; Hao Fu; Wen Cao
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By means of density functional theory (DFT) calculations, the investigation on the mechanism of the hydrogenation of diphenylacetylene (DPA) over Pd clusters was carried out at a molecular level.
Ricardo D. Huelsmann ; Francielle C. Turazzi; Guilherme M. O. Barra; Eduardo Carasek
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A fast and effective method for the determination of 18 organic micro-pollutants of five different classes in environmental waters by disposable pipette extraction (DPX) using polypyrrole (PPy) as extraction phase and gas chromatography-mass spectrometry (GC-MS) for separation and detection is developed.
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