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vol. 31, No. 10, 2020, p. 1965-2173

 

Cyclic imides have a wide range of important biological activities, which include anticancer, analgesic, antibacterial and antifungal activities. The synthesized compounds were obtained from safrole and showed antifungal activity against Candida and Cryptococcus strains. A conformational study was carried out, attributing the stereochemistry of one of the compounds. Details are presented in the Article Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole by Raquel F. Vilela, Normando A. S. Costa, Helivaldo D. S. Souza, Luiz E. G. Cruz, Kelyonara M. S. de Assis, Edeltrudes O. Lima, Laísa V. Cordeiro, Bruno F. Lira, Petronio F. de Athayde-Filho, Gerd B. Rocha and José M. Barbosa-Filho on page 2091.



Cover Article
J. Braz. Chem. Soc. 2020, 31(10), 2091-2103

Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole

Raquel F. Vilela; Normando A. S. Costa; Helivaldo D. S. Souza ; Luiz E. G. Cruz; Kelyonara M. S. de Assis; Edeltrudes O. Lima; Laísa V. Cordeiro; Bruno F. Lira; Petronio F. de Athayde-Filho; Gerd B. Rocha; José M. Barbosa-Filho

How to cite this article

Cyclic imides have a wide range of important biological activities, which include anticancer, analgesic, antibacterial and antifungal activities. The synthesized compounds were obtained from safrole and showed antifungal activity against Candida and Cryptococcus strains. A conformational study was carried out, attributing the stereochemistry of one of the compounds. Details are presented in the Article Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole by Raquel F. Vilela, Normando A. S. Costa, Helivaldo D. S. Souza, Luiz E. G. Cruz, Kelyonara M. S. de Assis, Edeltrudes O. Lima, Laísa V. Cordeiro, Bruno F. Lira, Petronio F. de Athayde-Filho, Gerd B. Rocha and José M. Barbosa-Filho on page 2091.

The cover image is adapted from https://togotv.dbcls.jp/togopic.2017.49.html TogoTV (©2016 DBCLS TogoTV) by Wakana Sasaki, licensed by Creative Commons Attribution 4.0 International

https://dx.doi.org/10.21577/0103-5053.20200110

Published online: June 9, 2020
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Letter J. Braz. Chem. Soc. 2020, 31(10), 1965-1970

Action Items for Latin-American Chemists and Chemical Societies to Improve Equity and Diversity in Science

Daniel G. Rivera

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The chemists from Latin-America need to do more to achieve equality in the scientific world and gain greater recognition by the broader chemical community. For this, we should rethink our strategy to fight for a more inclusive science, not only internationally but also within our region. Raise your hands and take actions to support this movement. The content of this Letter appears as Editorial jointly published in the American Chemical Society journals Organic Letters, The Journal of Organic Chemistry, Organometallics , and Inorganic Chemistry.

https://dx.doi.org/10.21577/0103-5053.20200156

Published online: August 17, 2020

 

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Articles J. Braz. Chem. Soc. 2020, 31(10), 1971-1978

Kinetic Parameters of the Thermal Oxidation and Degradation Reactions in Soybean Oil and Palm Olein

Alex S. Torquato; Paulo R. S. Bittencourt ; Fernando R. Scremin; Rosana A. da Silva-Buzanello; Thays R. Gonçalves; Makoto Matsushita

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The chemical reactions accompanying any thermal treatment of soybean oil or palm olein must be carefully monitored in the food industries, to ensure the quality and healthiness of processed foods.

https://dx.doi.org/10.21577/0103-5053.20200087

Published online: May 15, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 1979-1990

Analysis of the Gene Expression and RNAi-Mediated Knockdown of Chitin Synthase from Leaf-Cutting Ant Atta sexdens

Ariele C. Moreira; Renato L. Carneiro; Mariana F. Fracola; Kelli C. Micocci; Odair C. Bueno; Dulce H. F. Souza

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Analysis of the chitin synthase expression during Atta sexdens developmental stages.

https://dx.doi.org/10.21577/0103-5053.20200098

Published online: May 26, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 1991-1999

A Simple and Efficient Optimized Solid-Liquid Extraction with Low Temperature Partition Procedure for Dissipation and Translocation Study of Pesticide Residues in Rice Grains

Mariane B. R. de Ávila; Lêda R. A. Faroni; Fernanda F. Heleno; Maria Eliana L. R. de Queiroz ; Rodrigo I. Almeida

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It was studied the dissipation of insecticides residues in rice and the translocation of these insecticide residues in husked rice for 35 days. For that, the solid-liquid extraction methods with low temperature partition (SLE/LTP) method followed by gas chromatography with electron capture detection (GC-ECD) for unhulled and husked rice were optimized and validated.

https://dx.doi.org/10.21577/0103-5053.20200099

Published online: May 26, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2000-2011

Quick Identification of the Time of Maturation of Artisanal Minas Cheese by FTIR‑ATR Spectroscopy and Multivariate Techniques

Josane C. de Jesus; Grazielly J. Silva; Ben-Hur R. F. Gonçalves; Marcelo R. de Souza; Leandro S. Santos; Sibelli P. B. Ferrão

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Use of Fourier transform infrared spectroscopy combined with multivariate analysis to identify the maturation time of Minas artisanal cheese.

https://dx.doi.org/10.21577/0103-5053.20200100

Published online: May 26, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2012-2022

Temporal Evolution of Roughness Development on Polymer Surfaces Exposed to Non-Thermal Plasma

Taís Felix ; Luís O. B. Benetoli; Susana Sério; Marta E. R. Dotto; Nito A. Debacher

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Polymeric samples were exposed to non-thermal plasma, and roughness patterns were formed as a function of time. After extensive statistical analysis, it was observed that the patterns were repeated, and growth models could be proposed.

https://dx.doi.org/10.21577/0103-5053.20200101

Published online: May 27, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2023-2029

Cocoa Agro-Industrial Residue (Theobroma cacao) as Inducer of the Production of Fungal Laccase and Kojic Acid for Application in the Biodegradation of 17-α-Ethinylestradiol

Jhéssica C. S. Golveia ; Maria Teresa F. Bara ; Mariângela F. Santiago ; Luiza C. Campos ; Fernando Schimidt

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Biodegradation of 17-α-ethinylestradiol with laccase from fungi, using cocoa agro-industrial residue as inductor replacing the xylidine.

https://dx.doi.org/10.21577/0103-5053.20200102

Published online: May 29, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2030-2037

Absolute Configuration of (−)-Cubebin, a Classical Lignan with Pharmacological Potential, Defined by Means of Chiroptical Spectroscopy

Arthur L. Macedo ; Lucas H. Martorano ; Ana Carolina F. de Albuquerque; Rodolfo G. Fiorot ; José W. M. Carneiro ; Vinicius R. Campos ; Thatyana R. A. Vasconcelos ; Alessandra L. Valverde ; Davyson L. Moreira ; Fernando M. dos Santos Jr.

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Determination of the absolute configuration of (−)-cubebin by means of a robust combination of theoretical and experimental methods.

https://dx.doi.org/10.21577/0103-5053.20200103

Published online: May 29, 2020

 

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Crystal Data (CIF)

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J. Braz. Chem. Soc. 2020, 31(10), 2038-2048

Corrosion Protection of Steel by Volatile Corrosion Inhibitors: Vapor Analysis by Gas-Diffusion Microextraction and Mass Loss and Electrochemical Impedance in NaCl Deliquescence Tests

Marco A. G. Valente Jr. ; Luís M. Gonçalves ; Juliano Passaretti Filho; Arnaldo A. Cardoso; José A. Rodrigues; Cecilio S. Fugivara; Assis V. Benedetti

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A new methodology involving the gas diffusion microextraction was used for the analysis of volatile corrosion inhibitors. The inhibition efficiencies were evaluated by mass loss measurements using deliquescence NaCl crystal test.

https://dx.doi.org/10.21577/0103-5053.20200104

Published online: June 1, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2049-2057

Synthesis and Characterization of Hybrid Polymer Based on Functionalized Silica as Efficient Adsorbent for Heavy Metal Ions from Aqueous Solution

Ariane C. Ribicki; Mayara L. Sperandio; Viviane J. Van Haandel; Ruben A. Estrada; Sérgio T. Fujiwara

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Possible mechanisms involved in Cu2+, Cd2+ and Ni2+ adsorption on 3-n-propylimidazolium silsesquioxane chloride (SiImi+Cl-).

https://dx.doi.org/10.21577/0103-5053.20200105

Published online: June 1, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2058-2070

Novel N-Heterocyclic Carbene Silver(I) Complexes: Synthesis, Structural Characterization, Antimicrobial and Cytotoxicity Potential Studies

Ichraf Slimani; Ahlem Chakchouk-Mtibaa; Lotfi Mellouli; Lamjed Mansour; Ismail Ozdemir; Nevin Gürbüz; Naceur Hamdi

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In this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j) and their AgI complexes (3a-3j).

https://dx.doi.org/10.21577/0103-5053.20200107

Published online: June 3, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2071-2081

Pueraria lobata Root Constituents as Xanthine Oxidase Inhibitors and Protective Agents against Oxidative Stress Induced in GES-1 Cells

Xiaosheng Tang; Aiping Xiao; Shiyong Mei; Ping Tang; Licheng Ren; Liangliang Liu

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Four screened xanthine oxidase inhibitors could effectively enhance cell viability and protect injury of gastric epithelial cell lines (GES-1 cells) from oxidative stress.

https://dx.doi.org/10.21577/0103-5053.20200108

Published online: June 5, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2082-2090

Multivariate Analysis: Use of Doehlert Design (DD) for Optimization of a Simple Sample Preparation Procedure for the Determination of Inorganic Constituents in Cocoa Beans Employing Microwave Acid Digestion and ICP OES

Raimundo R. Gamela; Vinicius C. Costa; Matheus L. de Mello; Julia C. Romero; Fábio A. C. Amorim ; Edenir R. Pereira-Filho

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Cocoa beans analysis for the determination of inorganic constituents using inductively coupled plasma optical emission spectrometry (ICP OES) and previous sample preparation optimization employing multivariate analysis.

https://dx.doi.org/10.21577/0103-5053.20200109

Published online: June 9, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2091-2103

Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole

Raquel F. Vilela; Normando A. S. Costa; Helivaldo D. S. Souza ; Luiz E. G. Cruz; Kelyonara M. S. de Assis; Edeltrudes O. Lima; Laísa V. Cordeiro; Bruno F. Lira; Petronio F. de Athayde-Filho; Gerd B. Rocha; José M. Barbosa-Filho

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Starting from safrole, after three steps, we obtained cyclic imides with antifungal activity with minimum inhibitory concentration (MIC) of 0.17 µmol mL-1.

https://dx.doi.org/10.21577/0103-5053.20200110

Published online: June 9, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2104-2113

One-Step Isolation of Monoterpene Indole Alkaloids from Psychotria leiocarpa Leaves and Their Antiviral Activity on Dengue Virus Type-2

Jéssica O. Costa; Rodolfo S. Barboza ; Ligia M. M. Valente ; Thiago Wolff ; Mário Gomes ; Blanca Gallo; Luis A. Berrueta ; Iris P. Guimarães-Andrade; Daniel Gavino-Leopoldino; Iranaia Assunção-Miranda

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Three anti-dengue active monoterpene indole alkaloids were isolated in just one-step directly from the leaf MeOH extract of Psychotria leiocarpa.

https://dx.doi.org/10.21577/0103-5053.20200111

Published online: June 10, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2114-2119

Virtual Screening of Secondary Metabolites of the Family Velloziaceae J. Agardh with Potential Antimicrobial Activity

Anderson A. V. Pinheiro ; Renata P. C. Barros; Edileuza B. de Assis; Mayara S. Maia; Diego I. A. F. de Araújo; Kaio A. Sales; Luciana Scotti ; Josean F. Tavares ; Marcus T. Scotti ; Marcelo S. da Silva

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Virtual screening of a Velloziaceae family bank against Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Salmonella sp., using computational tools.

https://dx.doi.org/10.21577/0103-5053.20200112

Published online: June 10, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2120-2128

Preparation of a New Polymeric Deep Eutectic Solvent and Its Application in Vortex-Assisted Liquid-Liquid Microextraction of Parabens in Foods, Cosmetics and Pharmaceutical Products

Dandan Ge ; Ying Gao; Yunxin Cao; Enrui Dai; Lin Yuan

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A polymeric deep eutectic solvent composed of DL-menthol and polyethylene glycol 400 was prepared and used as extraction solvent in vortex-assisted liquid-liquid microextraction method combined with high performance liquid chromatography-diode array detector for the determination of parabens.

https://dx.doi.org/10.21577/0103-5053.20200113

Published online: June 12, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2129-2134

A Simple Approach to Analyze Sugar Nectar Composition in Flowers Using Capillary Electrophoresis and Enzymatic Assays

Dayanne M. Bordin; Samara G. C. Latgé; Graham Pyke; John Kalman; Philip Doble; Fernando A. Genta; Lucas Blanes

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Illustration of the separation of the three main sugars found in nectar samples: fructose, glucose and sucrose by capillary electrophoresis.

https://dx.doi.org/10.21577/0103-5053.20200114

Published online: June 16, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2135-2145

Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

Mariacaterina Lianza; Maria Helena Verdan; Jean Paulo de Andrade; Ferruccio Poli; Larissa C. de Almeida; Leticia V. Costa-Lotufo; Álvaro Cunha Neto; Sarah C. C. Oliveira; Jaume Bastida; Andrea N. L. Batista; João M. Batista Jr. ; Warley S. Borges

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Cytotoxic isoquinoline alkaloids were isolated from Hippeastrum goianum and had their absolute configurations determined by using vibrational circular dichroism (VCD).

https://dx.doi.org/10.21577/0103-5053.20200116

Published online: June 17, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2146-2154

Determination of Bisphenol A in Paper Products by Synchronous Fluorescence Spectroscopy and Estimation of Daily Exposure

Matheus Gallimberti; Bruno A. Rocha ; Vanessa C. O. Souza; Andres D. Campiglia; Fernando Barbosa Jr

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Fast determination of bisphenol A in paper samples and estimation of exposure via handling papers.

https://dx.doi.org/10.21577/0103-5053.20200117

Published online: June 17, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2155-2163

Theoretical Calculations on the Mechanism of Hydrogenation of Diphenylacetylene over Pdn (n = 1-4) Clusters

Yan Chen ; Yong Fang; Jinglong Pan; Hao Fu; Wen Cao

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By means of density functional theory (DFT) calculations, the investigation on the mechanism of the hydrogenation of diphenylacetylene (DPA) over Pd clusters was carried out at a molecular level.

https://dx.doi.org/10.21577/0103-5053.20200118

Published online: June 18, 2020

 

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J. Braz. Chem. Soc. 2020, 31(10), 2164-2173

Exploring Polypyrrole as Extraction Phase for Disposable Pipette Extraction Method for Multiclass Organic Micro-Pollutant Determination in River and Tap Water Using Gas Chromatography-Mass Spectrometry

Ricardo D. Huelsmann ; Francielle C. Turazzi; Guilherme M. O. Barra; Eduardo Carasek

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A fast and effective method for the determination of 18 organic micro-pollutants of five different classes in environmental waters by disposable pipette extraction (DPX) using polypyrrole (PPy) as extraction phase and gas chromatography-mass spectrometry (GC-MS) for separation and detection is developed.

https://dx.doi.org/10.21577/0103-5053.20200119

Published online: June 18, 2020

 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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