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The hydnocarpic acid isolated from Carpotroche brasiliensis seed oil was used to obtain a series of derivatives containing1,2,3-triazole ring. The derivative (R)-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl-11-(cyclopent-2-en-1-yl) undecanoate exhibited promising antiproliferative activity on the lung adenocarcinoma cell line by inhibiting cell cycle progression at G1 phase. Details are presented in the Article Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity by Liseth S. Osorio, Marisa Ionta, Antonio J. Demuner, Bianca L. de Sousa, Guilherme O. Ferraz, Eduardo V. V. Varejão, Guilherme A. F. Silva, Eduardo J. Pilau, Evandro Silva and Marcelo H. dos Santos on page 2500.
Liseth S. Osorio; Marisa Ionta; Antonio J. Demuner ; Bianca L. de Sousa ; Guilherme O. Ferraz; Eduardo V. V. Varejão; Guilherme A. Ferreira-Silva; Eduardo J. Pilau ; Evandro Silva ; Marcelo H. dos Santos
How to cite this articleThe hydnocarpic acid isolated from Carpotroche brasiliensis seed oil was used to obtain a series of derivatives containing1,2,3-triazole ring. The derivative (R)-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl-11-(cyclopent-2-en-1-yl) undecanoate exhibited promising antiproliferative activity on the lung adenocarcinoma cell line by inhibiting cell cycle progression at G1 phase. Details are presented in the Article Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity by Liseth S. Osorio, Marisa Ionta, Antonio J. Demuner, Bianca L. de Sousa, Guilherme O. Ferraz, Eduardo V. V. Varejão, Guilherme A. F. Silva, Eduardo J. Pilau, Evandro Silva and Marcelo H. dos Santos on page 2500.
Vinicius C. Costa; Diego V. Babos; Jeyne P. Castro; Daniel F. Andrade; Raimundo R. Gamela; Raquel C. Machado ; Marco A. Sperança; Alisson S. Araújo; José A. Garcia; Edenir R. Pereira-Filho
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Several calibration strategies have been reported in the literature over the last few years to improve quantitative analysis using laser-induced breakdown spectroscopy (LIBS).
Patricia M. A. Caetano ; Nathália M. Simões; Paula S. Pinto; Luis E. Fernandez‑Outon; Adriana S. Albuquerque; Waldemar A. A. Macedo; José D. Ardisson
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The adsorption and subsequent removal of amoxicillin from aqueous solution was investigated using nickel ferrite (NiFe2O4) nanoparticles.
Arthur C. C. Velho; José E. D. Martins
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(1S,2R)-Ephenamine was synthesized starting from commercially available chiral amino acid through straightforward procedures on a six-step methodology.
Fernanda B. Madeira; Victor G. P. Saide; Martha T. P. O. Castro; Cristina M. Barra; Sheisi F. L. S. Rocha; Vanessa G. K. Almeida; André V. S. Canuto; Gustavo G. Shimamoto; Matthieu Tubino ; José G. Rocha Jr.
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Gunshot residue (GSR) was analyzed with wavelength dispersion X-ray fluorescence spectrometry (WDXRF), discriminated according firearm/cartridge type by principal component analysis and classified as GSR and non-GSR by k-nearest neighbors (k-NN) method.
Woodland S. Oliveira; Josué C. C. Santos
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The fluorimetric method proved to be simple, rapid, and sensitive for determination of the total antioxidant capacity of drinks based on thiamine oxidation inhibition.
Érica S. Barbosa; Ane P. Cacique; Gevany P. de Pinho; Flaviano O. Silvério
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Representation of a valid methodology for determining CrIII and CrVI in sewage sludge samples by high performance liquid chromatography, inductively coupled plasma tandem mass spectrometry (HPLC-ICP-MS/MS).
Liseth S. Osorio; Marisa Ionta; Antonio J. Demuner ; Bianca L. de Sousa ; Guilherme O. Ferraz; Eduardo V. V. Varejão; Guilherme A. Ferreira-Silva; Eduardo J. Pilau ; Evandro Silva ; Marcelo H. dos Santos
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Conversion of hydnocarpic acid into a triazole compound 8 with antiproliferative activity (concentration able to inhibit 50% growth (IC50) = 63.96 ± 3.98 µM) against lung adenocarcinoma (A549).
Roberta da Silveira ; Patrícia D. S. dos Santos; Jessica S. Pizzo ; Nayane Mattos; Matheus C. de Castro; Oscar O. Santos ; Jesuí V. Visentainer
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Regarding the adulteration increase, it is essential to assess the guarantee levels declared by the manufacturers in the packaging of its products using analytical techniques.
Carla B. Vidal ; Pablo G. A. Barbosa; Germana P. Pessoa; Patrícia C. Buarque; José G. S. Nascimento; Antônio L. Farias Filho; Mário S. Paz; André B. dos Santos; Rivelino M. Cavalcante; Ronaldo F. Nascimento
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Solid phase extraction followed by high-performance liquid chromatography with diode array detection (SPE-HPLC-DAD) method was validated and applied to endocrine disruptors environmental monitoring detection; hormones, pharmaceuticals and plastic compounds were found in high concentration in sewage treatment plants in Ceará, Brazil; biological treatments showed some efficiency in removal of endocrine disruptors compounds, although a post-treatment step is necessary.
Banny S. B. Correia ; Gilberto G. D. Ortin; Natalia C. Mor; Maiara S. Santos; Raquel S. Torrinhas; Adalberto L. Val; Ljubica Tasic
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The evaluation of environmental effects on the lipids of Amazonian wild fishes is presented. Focus was given on seasonal dynamics of the river, eating habits, and tissue.
Dayse A. A. Silva; Diego M. da Costa; Larissa M. Oliveira; Hugo N. Brandão; Clayton Q. Alves; Aníbal F. Santos Jr. ; Manoelito C. dos Santos Jr.
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Identification of flavonoids as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein (ACP) reductase was evaluated by hierarchical virtual screening and intermolecular interactions contributed to the molecular recognition process.
Robson M. de Jesus; Geovani C. Brandão; Walter N. L. dos Santos; Leila O. dos Santos; Jailson B. de Andrade
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Hg is quantitatively extracted from the sediment using a new chelating reagent dithiothreitol.
Isabela F. B. Biscaia; Vitor Todeschini; Rafaela Z. C. de Meira; Camila Nogueira; Larissa S. Bernardi; Paulo R. de Oliveira
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First-order derivative spectrum of lamotrigine and nicotinamide allows the simultaneous assay of the drugs in cocrystals.
Suély Copini; Ana C. Micheletti ; Dênis P. de Lima ; Roberto S. Gomes ; Alisson Meza; Adilson Beatriz
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Twenty-eight novel organosulfur compounds were synthesized from a molecular combination of cardanol and glycerol derivatives, with excellent yields and employing more environmentally friendly processes.
Suzanny P. Carvalho; Rocio M. M. Dip; Elizabete F. Lucas
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Steps of the cleaning treatment for produced water aiming the analyses of the polymer by size-exclusion chromatography.
Emmely O. Trindade; Thalisson F. Dutra; Maria C. R. Brandão; Hermes Diniz Neto ; Edeltrudes O. Lima; Bruno F. Lira; Petrônio F. de Athayde-Filho; José M. Barbosa-Filho
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Fifteen new piperine derivatives were planned and synthesized. The new compounds were obtained through the substitution reaction between δ-chloro-esters and potassium piperate, and were evaluated through in silico study and in vitro for antimicrobial activity.
Tiago A. M. Lopes; Antonio C. Godoy; Nayane B. M. Sinosaki; Patrícia D. S. Santos; Lucas U. R. Chiavelli; Roberta Silveira ; Bruno H. Figueiredo; Jesuí V. Visentainer ; Oscar O. Santos
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The extraction of bioactive compounds present in rosemary (R. officinalis L.) using water as solvent comprises the context of green chemistry, as non-toxic solvent, high availability and low cost. It is necessary to optimize the extraction methods in order to obtain a high concentration of antioxidant compounds.
Hauster M. C. de Paula; Yara L. Coelho; Alan S. B. de Castro; Jaqueline P. Rezende; Ana C. S. Pires; Luis H. M. da Silva
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Bovine serum albumin (BSA) interacts with azure B (AZB) or azure A (AZA) through a transition complex. The formation of activated and thermodynamically stable complexes was entropy-driven at 25 °C.
Xuemei Fan ; Shumin Wang ; Zhejian Li ; Yimeng Wang; Xinhui Fan; Lingmin Yu
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A sensitive electrochemiluminescence biosensing platform for the detection of Hg2+ was designed via dual-amplification strategy.
Bolivar R. Amaro; Caio C. S. Alves; Gabriella F. Ferreira; Paloma E. Carvalho; Jeferson G. da Silva; Cleonice A. Souza; Oswaldo Cardoso Jr.; Alessandra P. Carli; Fabiana S. Machado; Ângelo M. L. Denadai; Sandra B. R. Castro
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Inclusion complexes of β-cyclodextrin/ofloxacin (βCD/OFLOX) and hydroxypropyl-β-cyclodextrin/ofloxacin (HPβCD/OFLOX) enhance the solubility and bioavailability with increased antitumor and apoptosis induction activity.
Corilagin docked into the binding site of coronavirus 2 (CoV-2) main protease.
Oscar C. da Silva Neto; Marla T. F. Teodoro; Bruna O. do Nascimento; Klauber V. Cardoso ; Eliane O. Silva ; Jorge M. David ; Juceni P. David
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Bergenin of Peltophorum dubium roots and its alkyl alcohol derivatives displayed moderate and good inhibitory effects on
Artemia salina, Staphylococcus aureus, and acetylcholinesterase (AChE).
Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
JBCS Editorial and Publishing Office
University of Campinas - UNICAMP
13083-970 Campinas-SP, Brazil
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