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vol. 32, No. 10, 2021, p. 1895-2021

 

The use of lipases in organic synthesis is a useful tool to obtain high value chiral compounds. However, the enzymatic resolution allows only 50% of maximum yield. To circumvent this issue the discovery of new racemization agents is desirable. In this unprecedented work, we observed that niobium phosphate could racemize chiral 1-phenylethanol. And this new reactivity of niobium led to the development of a DKR (dynamic kinetic resolution) protocol. Details are presented in the Article Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents by Vanessa M. Higa, Willian S. Rocha, Mirela Inês de Sairre and Álvaro T. Omori on page 1956.


Cover Article
J. Braz. Chem. Soc. 2021, 32(10), 1956-1962

Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents

Vanessa M. Higa ; Willian S. Rocha; Mirela Inês de Sairre; Álvaro T. Omori

How to cite this article

The use of lipases in organic synthesis is a useful tool to obtain high value chiral compounds. However, the enzymatic resolution allows only 50% of maximum yield. To circumvent this issue the discovery of new racemization agents is desirable. In this unprecedented work, we observed that niobium phosphate could racemize chiral 1-phenylethanol. And this new reactivity of niobium led to the development of a DKR (dynamic kinetic resolution) protocol. Details are presented in the Article Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents by Vanessa M. Higa, Willian S. Rocha, Mirela Inês de Sairre and Álvaro T. Omori on page 1956.

https://dx.doi.org/10.21577/0103-5053.20210086

Published online: June 14, 2021
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Review J. Braz. Chem. Soc. 2021, 32(10), 1895-1911

Iron Ore Tailings: Characterization and Applications

Ottávio R. Carmignano; Sara S. Vieira ; Ana Paula C. Teixeira; Fernando S. Lameiras; Paulo Roberto G. Brandão; Rochel M. Lago

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Iron ore tailings (IOT) are mainly composed of iron oxides, silica, and other minerals such as kaolinite. The IOT can be used for different applications related to the civil construction and a variety of technological applications.

https://dx.doi.org/10.21577/0103-5053.20210100

Published online: July 14, 2021

 

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Articles J. Braz. Chem. Soc. 2021, 32(10), 1912-1917

Estimating the Electrochemically Active Area: Revisiting a Basic Concept in Electrochemistry

Dyovani Coelho; Giuliana M. Luiz; Sergio A. S. Machado

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Roughness factors increase with platinization time, but cyclic voltammetry cannot detect it.

https://dx.doi.org/10.21577/0103-5053.20210080

Published online: May 27, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1918-1930

Spondias purpurea L. Stem Bark Extract: Antioxidant and in vitro Photoprotective Activities

Francisco Alessandro M. Rodrigues ; Priscylla S. Giffony; Sarah B. F. dos Santos ; Jhonyson A. C. Guedes ; Maria Elenir N. P. Ribeiro ; Tamara G. de Araújo; Larissa M. R. da Silva; Guilherme J. Zocolo ; Nágila M. P. S. Ricardo

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Chemical profile, the antioxidant capacity and in vitro photoprotective action of phenolic extracts of Spondias purpurea L. in sunscreen formulations.

https://dx.doi.org/10.21577/0103-5053.20210082

Published online: June 7, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1931-1942

Preparation, Spectral Characterization and Anticancer Potential of Cinnamic Esters

Renan O. Gonçalves ; Iolanda F. de Farias; Maria Francilene S. Silva; Cláudia Ó. Pessoa; Guilherme J. Zocolo ; Davila Zampieri; Telma Leda G. de Lemos; Francisco Jose Q. Monte

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Synthesis and characterization of esters derived from cinnamic acid through Steglich reaction and evaluated in tumor cells.

https://dx.doi.org/10.21577/0103-5053.20210084

Published online: June 11, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1943-1955

Molecular Docking Studies of Curcumin Analogues against SARS-CoV-2 Spike Protein

Jéssica R. Nogueira; Flávia A. Verza; Felipe Nishimura; Umashankar Das; Ícaro P. Caruso; Ana L. Fachin; Jonathan R. Dimmock; Mozart Marins

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Molecular docking studies reveals that curcumin analogues have the potential to inhibit severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike protein interaction with host receptor.

https://dx.doi.org/10.21577/0103-5053.20210085

Published online: June 11, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1956-1962

Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents

Vanessa M. Higa ; Willian S. Rocha; Mirela Inês de Sairre; Álvaro T. Omori

How to cite this article

 

Dynamic kinetic resolution of 1-phenylethanol by combination of niobium salts and lipase.

https://dx.doi.org/10.21577/0103-5053.20210086

Published online: June 14, 2021

 

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Total access: 1388


J. Braz. Chem. Soc. 2021, 32(10), 1963-1971

The Effects of the Solvents on the Macrocyclic Structures: From Rigid Pillararene to Flexible Crown Ether

Shuangshuang Wang ; Yanzhen Yin; Jian Gao; Xingtang Liang; Haixin Shi

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The four macrocyclic molecules were built and used for studying the effects of the solvents on the macrocyclic structures.

https://dx.doi.org/10.21577/0103-5053.20210088

Published online: June 15, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1972-1987

Chromogenic Chemosensors Based on Phenolic Imines for the Detection of Alkylamines and Lidocaine in Water and in the Vapor Phase

Eduardo A. Ribeiro; Vanderlei G. Machado

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Three phenolic imines were used as chromogenic chemosensors to detect alkylamines in water. The system allows the detection of vapors of alkylamines and quantification of lidocaine in water.

https://dx.doi.org/10.21577/0103-5053.20210089

Published online: June 18, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 1988-1996

New Potential Use of Protium spruceanum in Hyperglycemia: α-Glucosidase Inhibition and Protection against Oxidative Stress

Tatiane R. Amparo; Francine M. Djeujo; Débora S. da Silva; Janaina B. Seibert; Ivanildes V. Rodrigues; Orlando D. H. Santos; Geraldo C. Brandão; Paula M. A. Vieira; Guglielmina Froldi ; Gustavo H. B. de Souza

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Protium spruceanum branches: phytochemistry, anti-α-glucosidase activity, and cytoprotection against oxidative stress.

https://dx.doi.org/10.21577/0103-5053.20210090

Published online: June 21, 2021

 

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Total access: 720


J. Braz. Chem. Soc. 2021, 32(10), 1997-2008

Integration of Statistical Models and Computer Simulation in Environmental Accidents: A Study on Leakage of Red Mud in the Pará River, Amazon, Brazil

Pedro M. de Sousa Jr.; Simone F. P. Pereira; Ronaldo M. Rocha; Mateus H. D. Alves; Luciana S. Pinheiro; Daniel P. Nogueira; Orivan M. M. Teixeira; Auriane C. S. Gonçalves

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The graph is intended to illustrate how beneficial it is for environmental research to integrate individually recognized statistical and computer simulation models in the production of realistic scenarios and decision-making regarding the mitigation of environmental disasters.

https://dx.doi.org/10.21577/0103-5053.20210091

Published online: June 23, 2021

 

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J. Braz. Chem. Soc. 2021, 32(10), 2009-2016

Shelf Life of Bioactive Compounds from Acerola Pulp (Malpighia spp.) through Freeze-Drying and Microencapsulation

Bruno H. F. Saqueti; Eloize S. Alves; Matheus C. Castro ; Patrícia D. S. dos Santos; Nayane B. M. Sinosaki; Carlos E. R. Senes ; Jesuí V. Visentainer ; Oscar O. Santos

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The antioxidant activity, bioactive compounds, and storage stability of acerola pulp were evaluated using three different conservation methods: frozen (FAP), freeze-drying (LAP), and microencapsulated and freeze-drying (MLAP).

https://dx.doi.org/10.21577/0103-5053.20210096

Published online: July 5, 2021

 

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Short Report J. Braz. Chem. Soc. 2021, 32(10), 2017-2021

Octadecanal as the Male-Produced Aggregation Pheromone of the Coconut Weevil, Amerrhinus ynca (Coleoptera: Curculionidae)

Palmira L. dos Santos Neta; Carla F. Fávaro ; Sarah O. Macedo; José Inácio L. Moura; Jan E. Bello; Rândilla R. C. Santos;
Paulo H. G. Zarbin

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Amerrhinus ynca produces a male-specific compound, and by using chemical analysis of volatile extracts the molecule was identified as octadecanal. Indoor bioassays employing a synthetic sample suggested the molecule as being the aggregation pheromone of species.

https://dx.doi.org/10.21577/0103-5053.20210087

Published online: June 14, 2021

 

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Total access: 909

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
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