JBCS

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vol. 32, No. 12, 2021, p. 2153-2277

 

The CuAAC reaction was used to prepare a series of novel triazole cinnamides derivatives and a bis cinnamate. The antiproliferative and antimetastatic activities of the compounds were evaluated in vitro on a melanoma B16-F10 cell line. The most effective compound reduced the viability and influenced the metastatic behavior of melanoma cells by decreasing migration, invasion, and colony formation. Details are presented in the Article Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells by Fabíola S. Santos, Juliana A. do Vale, Lucas S. Santos, Talita B. Gontijo, Graziela D. A. Lima, Leandro L. de Oliveira, Mariana Machado-Neves, Róbson R. Teixeira and Rossimiriam P. de Freitas on page 2174.


Cover Article
J. Braz. Chem. Soc. 2021, 32(12), 2174-2185

Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells

Fabíola S. Santos; Juliana A. do Vale; Lucas S. Santos; Talita B. Gontijo; Graziela D. A. Lima; Leandro L. de Oliveira ; Mariana Machado-Neves; Róbson R. Teixeira ; Rossimiriam P. de Freitas

How to cite this article

The CuAAC reaction was used to prepare a series of novel triazole cinnamides derivatives and a bis cinnamate. The antiproliferative and antimetastatic activities of the compounds were evaluated in vitro on a melanoma B16-F10 cell line. The most effective compound reduced the viability and influenced the metastatic behavior of melanoma cells by decreasing migration, invasion, and colony formation. Details are presented in the Article Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells by Fabíola S. Santos, Juliana A. do Vale, Lucas S. Santos, Talita B. Gontijo, Graziela D. A. Lima, Leandro L. de Oliveira, Mariana Machado-Neves, Róbson R. Teixeira and Rossimiriam P. de Freitas on page 2174.

https://dx.doi.org/10.21577/0103-5053.20210109

Published online: August 3, 2021
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Articles J. Braz. Chem. Soc. 2021, 32(12), 2153-2159

Polycyclic Aromatic Hydrocarbon (PAHs) Analyses in Marine Tissues Using Accelerated Solvent Extraction (ASE) in Tandem with In-Cell Purification and GC-MS

Camilla V. G. Pinheiro; Renato S. Carreira ; Carlos G. Massone

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Fast and eco-friendly extraction method aligned with green-chemistry guidelines developed for polycyclic aromatic hydrocarbons (PAHs) extraction from marine tissues.

https://dx.doi.org/10.21577/0103-5053.20210107

Published online: July 28, 2021

 

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Total access: 983


J. Braz. Chem. Soc. 2021, 32(12), 2160-2173

A Reliable and Cost-Effective Method for Determination of Endocrine-Disrupting Compounds in Coastal Waters, Suspended Particulate Matter, and Sediments by Ultrafast Liquid Chromatography Coupled to Photodiode Array and Fluorescence Detectors

Gabriel C. de Souza ; Cristiane S. Fahning; Vanessa Hatje ; Gisele O. da Rocha

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Analytical methods for determining endocrine-disrupting compounds (EDCs) in coastal waters, suspended particles, and sediment were performed and applied in samples collected from Todos os Santos Bay (BTS), Bahia, Northeastern Brazil.

https://dx.doi.org/10.21577/0103-5053.20210108

Published online: July 28, 2021

 

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J. Braz. Chem. Soc. 2021, 32(12), 2174-2185

Synthesis of Novel Cinnamides and a Bis Cinnamate Bearing 1,2,3-Triazole Functionalities with Antiproliferative and Antimetastatic Activities on Melanoma Cells

Fabíola S. Santos; Juliana A. do Vale; Lucas S. Santos; Talita B. Gontijo; Graziela D. A. Lima; Leandro L. de Oliveira ; Mariana Machado-Neves; Róbson R. Teixeira ; Rossimiriam P. de Freitas

How to cite this article

 

Compound 6b decreased melanoma cell viability. It also caused cell cycle arrest and reduced migration, invasion and colony formation.

https://dx.doi.org/10.21577/0103-5053.20210109

Published online: August 3, 2021

 

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Total access: 1387


J. Braz. Chem. Soc. 2021, 32(12), 2186-2194

Detection of 2,4-Dinitrophenol and Bio-Imaging Application with Agaric-Based Nitrogen-Doped Carbon Quantum Dots (N-CQDs)

Jiao Zhao ; Xianhao Long; Zhihua Li; Yujiao Tu

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Green synthesis of high fluorescent carbon quantum dots from agarics.

https://dx.doi.org/10.21577/0103-5053.20210110

Published online: August 3, 2021

 

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J. Braz. Chem. Soc. 2021, 32(12), 2195-2205

Forced Degradation Study and Development of a Stability-Indicating Method for Amoxicillin Capsules According to ANVISA Guidelines

Margareth B. C. Gallo ; Diogo D. do Nascimento; Nelson M. Nunes; Flávia F. M. de Sousa; Janine Boniatti ; José L. N. de Aguiar; Juliana J. S. Medeiros ; Alessandra L. Esteves; Graça M. S. Guerra ; Luiz E. M. Ferreira; Lucas G. I. Regis; Rafael C. Seiceira; Fabiana M. S. U. Moncorvo; Marcelo H. C. Chaves

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Development and validation of a stability-indicating method for amoxicillin 500 mg capsules.

https://dx.doi.org/10.21577/0103-5053.20210111

Published online: August 5, 2021

 

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Total access: 1082


J. Braz. Chem. Soc. 2021, 32(12), 2206-2214

Phenolic Composition of Dipteryx alata Vogel Pulp + Peel and Its Antioxidant and Cytotoxic Properties

Érica O. Barizão; Joana S. Boeing ; Eliza M. Rotta ; Hélito Volpato; Celso V. Nakamura; Liane Maldaner ; Jesuí V. Visentainer

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Phenolic composition of Dipteryx alata Vogel pulp + peel extracted with different solvents and its antioxidant and cytotoxic properties were investigated for the first time.

https://dx.doi.org/10.21577/0103-5053.20210112

Published online: August 6, 2021

 

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Total access: 841


J. Braz. Chem. Soc. 2021, 32(12), 2215-2221

Arrays of Copper Microelectrodes from Disposable Chips: Fabrication and Characterization

Giane S. Higino ; Ítalo R. Machado; Gabriel F. Nascimento; Jairo J. Pedrotti

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Platforms with arrays of copper microelectrodes obtained from disposable electronic chips were fabricated and evaluated for electroanalytical applications.

https://dx.doi.org/10.21577/0103-5053.20210113

Published online: August 6, 2021

 

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Total access: 797


J. Braz. Chem. Soc. 2021, 32(12), 2222-2234

Synthesis of BODIPY-Amino Acids and the Potential Applications as Specific Dyes for the Cytoplasm of Langerhans β-Cells

Jorge A. Aguilera; Víctor García-González; Manuel Alatorre-Meda; Eustolia Rodríguez-Velázquez; Ignacio A. Rivero

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Synthetized 4,4-difluoro-4-bora-3a,4a-diazas-indacene bound to amino acids (BODIPY-AA) conjugates are a novel attractive tool for the specific staining of the cell cytoplasm.

https://dx.doi.org/10.21577/0103-5053.20210114

Published online: August 10, 2021

 

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Total access: 933


J. Braz. Chem. Soc. 2021, 32(12), 2235-2244

Novel Method for the Extraction of Cocaine from Oral Fluid by Means of Disposable Pipette Modified with Restricted Access Material

Ludmyla S. Tavares; Ricardo A. Bernardo; Anselmo E. de Oliveira; Boniek G. Vaz ; Andrea R. Chaves

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A new reliable extractive phase for disposable pipette extraction is developed, and its performance was evaluated in extractions of cocaine in saliva samples using high performance liquid chromatography coupled to mass spectrometry.

https://dx.doi.org/10.21577/0103-5053.20210115

Published online: August 11, 2021

 

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Total access: 992


J. Braz. Chem. Soc. 2021, 32(12), 2245-2256

Coal Fly Ash Waste, a Low-Cost Adsorbent for the Removal of Mordant Orange Dye from Aqueous Media

Teresa Rosa; Angela Martins ; Maria T. Santos; Teodoro Trindade; Nelson Nunes

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Adsorption of Mordant Orange dye by coal fly ash was studied. The influence of temperature and pH was analyzed through isotherm adsorption models.

https://dx.doi.org/10.21577/0103-5053.20210116

Published online: August 17, 2021

 

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Total access: 749


J. Braz. Chem. Soc. 2021, 32(12), 2257-2263

Radial Distribution Function for a Hard Sphere Liquid: A Modified Percus-Yevick and Hypernetted-Chain Closure Relations

Felipe S. Carvalho ; João Pedro Braga

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Radial distribution function for a hard sphere fluid from Ornstein-Zernike equations and closure relations.

https://dx.doi.org/10.21577/0103-5053.20210117

Published online: August 18, 2021

 

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Total access: 668


J. Braz. Chem. Soc. 2021, 32(12), 2264-2271

Study of Fe3O4/PS System in Degrading BPA in Aqueous Solution

Tie-Hong Song; Yan-Jiao Gao ; Su-Yan Pang; Rui-Hua Hu; Han-Bo Li

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A Fe3O4/persulfate system was used to remove bisphenol A, an emerging endocrine disruptor, in water. The effects of the pH value, reaction temperature, concentrations of Fe3O4, persulfate and bisphenol A on bisphenol A degradation were studied in detail. Free radicals scavenging experiments were performed and the intermediate products of bisphenol A degradation were identified.

https://dx.doi.org/10.21577/0103-5053.20210118

Published online: August 19, 2021

 

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Total access: 671


Additions and Corrections J. Braz. Chem. Soc. 2021, 32(12), 2272


 

https://dx.doi.org/10.21577/0103-5053.20210141

Published online: October 27, 2021

 

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Total access: 287


J. Braz. Chem. Soc. 2021, 32(12), 2273-2277

JBCS Reviewer List - 2021


 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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University of Campinas - UNICAMP
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