JBCS

Alternative approaches by endiandric acids and kingianins from Endiandra kingiana can help to inhibit α-amylase and α-glucosidase activities and hence may considered for the development of new anti-diabetic agents.

In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the Streptococcus mutans in vitro and the acute toxicity of the better ones in vivo.

Benzothiazole and benzimidazole were urease inhibitors evaluated through enzymatic activity assays, molecular fluorescence techniques, and molecular modeling.

Discrimination of analysis of the chemical profile from pequi pericarp flour extracts using paper spray ionization.

Synthesis and molecular modeling studies on supramolecular arrangement of (6,5) bromo-2,3-dimethoxybenzaldehyde.

Thiopyrimidinone derivatives were synthesized and evaluated as inhibitors for the aldose reductase enzyme by in vitro and in silico studies, leading to candidates that showed half maximal inhibitory concentration (IC₅₀) from 2.0 to 14 micromolar.

In this work we developed a procedure using bar adsorptive microextraction (BAµE) associated with histamine-functionalized magnetic nanoparticles (HIS-MNP) as sorbent to determine parabens in water samples.

The obtained fluorescent π-conjugated molecules based on dithienopyrrole derivatives and pyrene exhibited the detection of herbicide mesotrione due to fluorescence quenching through fluorescence resonance energy transfer (FRET) mechanism, where synthesized π-conjugated molecules as donor chromophore transfer energy to mesotrione as acceptor chromophore through nonradiative dipole-dipole coupling.

Pretreatment of four lignocellulosic biomasses using the organosolv method with glycerol and FeCl₃, followed by filtration and enzymatic hydrolysis of the pretreated biomass, resulting in a liquid abundant in glucose.

A series of oxazolidinone derivatives 3a-3v were designed and synthesized. Compound 3g displayed the best inhibitory activity, with a half maximal inhibitory concentration (IC₅₀) value of 14.47 µM.