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vol. 35, No. 2, 2024, p. 1-15

 

The artwork summarizes the drug discovery pathway, tracing the journey from the initial motivation to find a cure for a specific disease to the intricate development of novel lead compounds. It visually delineates the key steps, emphasizing the structure of a reported quinoline-thiazole hybrid and showcasing the in silico studies conducted in this research. Details are presented in the Article Design, Synthesis, and Molecular Docking Studies of New Quinoline‑Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents by Victor Facchinetti, Claudia Regina B. Gomes, Karoline C. L. Aboud, Rodolfo G. Fiorot, Guilherme G. C. de Carvalho, Carlos Roberto K. Paier, Claudia do Ó Pessoa, Anne Caroline C. Gomes, Marcus Vinícius N. de Souza and Thatyana R. A. Vasconcelos on e-20230139.


Cover Article
J. Braz. Chem. Soc. 2024, 35(2), 1-12

Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents

Victor Facchinetti; Claudia Regina B. Gomes; Karoline C. L. Aboud; Rodolfo G. Fiorot ; Guilherme G. C. de Carvalho;
Carlos Roberto K. Paier; Claudia do Ó Pessoa; Anne Caroline C. Gomes; Marcus Vinícius N. de Souza ; Thatyana R. A. Vasconcelos

How to cite this article

The artwork summarizes the drug discovery pathway, tracing the journey from the initial motivation to find a cure for a specific disease to the intricate development of novel lead compounds. It visually delineates the key steps, emphasizing the structure of a reported quinoline-thiazole hybrid and showcasing the in silico studies conducted in this research. Details are presented in the Article Design, Synthesis, and Molecular Docking Studies of New Quinoline‑Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents by Victor Facchinetti, Claudia Regina B. Gomes, Karoline C. L. Aboud, Rodolfo G. Fiorot, Guilherme G. C. de Carvalho, Carlos Roberto K. Paier, Claudia do Ó Pessoa, Anne Caroline C. Gomes, Marcus Vinícius N. de Souza and Thatyana R. A. Vasconcelos on e-20230139.

https://dx.doi.org/10.21577/0103-5053.20230139

Published online: August 17, 2023
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Articles J. Braz. Chem. Soc. 2024, 35(2), 1-12

Plectranthus amboinicus Essential Oil Incorporated into Fish Feed Shows Strong Antimicrobial Activity against Aeromonas hydrophila, an Opportunistic Bacterium of Aquaculture

Juliane M. S. Silva; Flávia C. R. Vilar; Gabriel A. B. Lima; Elizangela M. Souza; Livia M. Dutra; Jackson R. G. S. Almeida ;
Larissa A. Rolim; Norberto P. Lopes ; Ana P. Oliveira

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Plectranthus amboinicus extracts using carvacrol as a major compound bring out antibacterial activity against Aeromonas hydrophila strains isolated or incorporated into fish feed.

https://dx.doi.org/10.21577/0103-5053.20230087

Published online: May 31, 2023

 

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J. Braz. Chem. Soc. 2024, 35(2), 1-7

Canonical Unified Statistical Rate Constants Using a High-Level Composite Coupled Cluster Energy Scheme for the CH4 + CH Reaction

Jonas A. Leite Júnior ; Carlos M. R. Rocha ; Antonio G. S. de Oliveira-Filho

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High-level electronic structure and transition-state theory calculations lead to agreement with experimental rate constant measurements for the barrierless CH4 + CH gas-phase reaction.

https://dx.doi.org/10.21577/0103-5053.20230107

Published online: July 4, 2023

 

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J. Braz. Chem. Soc. 2024, 35(2), 1-10

Use of High-Efficiency Lignocellulose-Based Materials for Toxic Ions Removal: Impact of Surface Chemistry and Mathematical Modeling

Diego Q. Melo; Lucas F. Amorim; Juliene T. Oliveira; João A. N. da Cunha Junior; André H. B. de Oliveira; André G. de Oliveira;
Carla B. Vidal ; Ronaldo F. do Nascimento

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Turning agricultural waste into a value-added adsorbent promotes a positive environmental impact. Castor stalks waste is highly abundant and inexpensive, and alkali treatment boosted its adsorption capacity. Castor stalk showed to be a high-performance and low-cost adsorbent.

https://dx.doi.org/10.21577/0103-5053.20230108

Published online: July 6, 2023

 

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Total access: 707


J. Braz. Chem. Soc. 2024, 35(2), 1-14

What Can We Learn about Improvements in Air Quality During the COVID-19 Pandemic? A Case Study in Four Cities Located in the Same State but with Different Emission Profiles

Jonatas S. Carvalho ; Gabriel M. Ferraz; Hugo L. I. Betim; Rita de Kássia S. do Nascimento ; Caroline Scaramboni;
Roberta C. Urban

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With mobility restrictions in response to the coronavirus disease 2019 (COVID-19) pandemic, there was a reduction in vehicle and industrial emissions. However, there were also many fires in São Paulo State, which increased the concentrations of some air pollutants.

https://dx.doi.org/10.21577/0103-5053.20230110

Published online: July 7, 2023

 

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J. Braz. Chem. Soc. 2024, 35(2), 1-11

Design, Synthesis and Insecticidal Activity of Novel meta-Diamide Compounds Containing Methoxy Group

Limei Liang ; Minghui Wu; Pengmian Huang; Jiyong Liu

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Design, synthesis and insecticidal activity of novel meta-diamide compounds containing methoxy group.

https://dx.doi.org/10.21577/0103-5053.20230111

Published online: July 10, 2023

 

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Total access: 682


J. Braz. Chem. Soc. 2024, 35(2), 1-15

Evaluation of the Profiles of Essential and Potentially Toxic Elements Present in Grape Must Grown and Soil from the Region Submedium São Francisco, Brazil

Vanessa S. Santos; Rennan G. O. Araujo ; Tarcísio S. Almeida; Wagna P. C. dos Santos; Maria das Graças A. Korn

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The study evaluated the distribution of multi-element in grape must samples and in soil employing inductively coupled plasma optical emission spectrometry (ICP OES), to establish a profile of the different types of grapes and estimated contamination levels of the grape growing area through background values.

https://dx.doi.org/10.21577/0103-5053.20230112

Published online: July 10, 2023

 

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Total access: 591


J. Braz. Chem. Soc. 2024, 35(2), 1-11

Study of the Interference in Target Seed Germination Caused by Dienamides and Epoxy Derivatives, in the Search for New Herbicides

Danielle S. Ramos ; Elson S. Alvarenga ; Júnio G. Silva ; Cristiane I. Cerceau ; Suélen K. Sartori ; Vania M. T. Carneiro ; Denilson F. Oliveira

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Novel potential herbicides were synthesized from sorbic acid and their phytotoxic activities were evaluated against sorghum, onion, cucumber, lettuce, and beggartick seeds. Furthermore, the protein target of the most active substance in plants was identified in silico.

https://dx.doi.org/10.21577/0103-5053.20230113

Published online: July 11, 2023

 

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Total access: 679


J. Braz. Chem. Soc. 2024, 35(2), 1-12

Synthesis and Characterization of Ezetimibe Pharmaceutical Cocrystal: A Reaction Crystallization Method to Improve Physicochemical Properties and Hypolipemic Activity Evaluation

Débora F. V. Ronik; Andressa P. Hosni; Rafaela C. Brancalione; Isabela F. B. Biscaia; Larissa S. Bernardi; Paulo R. de Oliveira

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Ezetimibe pharmaceutical cocrystal was obtained by reaction crystallization method to increase drug solubility.

https://dx.doi.org/10.21577/0103-5053.20230114

Published online: July 13, 2023

 

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Total access: 690


J. Braz. Chem. Soc. 2024, 35(2), 1-7

Dye-Sensitized TiO2 as Heterogenous Visible Light Photocatalyst for the Hydroxylation of Aryl Boronic Acids

Juan E. Argüello ; Adrián A. Heredia ; Lydia M. Bouchet

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We report the preparation of a number of nanohybrids based on dye-sensitized TiO2 composites. Their application as heterogeneous photocatalyst for the oxidative hydroxylation of boronic acids and esters to synthesize phenols was investigated.

https://dx.doi.org/10.21577/0103-5053.20230115

Published online: July 17, 2023

 

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Total access: 672


J. Braz. Chem. Soc. 2024, 35(2), 1-11

Antiproliferative, Anti-Inflammatory and Anti-Microbial Activities of Synthesized Benzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine and Benzo[f]benzo[4,5]oxazolo[3,2-d][1,4]oxazepine Derivatives

Khalid M. Abu Khadra ; Huda A. AL-Saadi; Areej M. Assaf; Firas F. Awwadi; Shehadeh Mizyed

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Benzoxazepine derivatives with promising broad biological activities have been synthesized. X-ray crystal structure of compound (10,11-dimethyl-6,7-dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine) and compound (8,9-dihydrobenzo [4,5]imidazo[1,2-d]naphtho[1,2-f][1,4]oxazepine) were obtained.

https://dx.doi.org/10.21577/0103-5053.20230116

Published online: July 18, 2023

 

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Total access: 643


J. Braz. Chem. Soc. 2024, 35(2), 1-8

Green, Water-Based Synthesis of ZnO Nanostructures

Denise Criado ; Alejandro Zúñiga; Antonio Pepinelli

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ZnO nanostructures synthesized by simply immersing Zn plates in water.

https://dx.doi.org/10.21577/0103-5053.20230117

Published online: July 19, 2023

 

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Total access: 540


J. Braz. Chem. Soc. 2024, 35(2), 1-8

Monoaromatic Fluorescence Probe for Sensitive Alkaline Phosphatase Analysis by Regulating Intramolecular Hydrogen Bonding

Xiaoqing Zhang ; Yi Chen

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Sensitive and fluorimetric alkaline phosphatase (ALP) detection using monoaromatic probe via regulating intramolecular hydrogen bonding is proposed.

https://dx.doi.org/10.21577/0103-5053.20230119

Published online: July 24, 2023

 

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J. Braz. Chem. Soc. 2024, 35(2), 1-15

Effects of Pectinase Treatment on the Optimization and Extraction of Pigments from Bacupari, Tucumã, and Peach Palm Using Response Surface Methodology

Pedro H. S. Miranda; Rômulo A. Morais ; Hermanny M. S. Sousa; Larissa S. Gualberto; Barbara C. B. Freitas; Eduardo R. Asquieri; Glêndara A. S. Martins; Eduardo V. B. V. Boas; Clarissa Damiani

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Obtaining natural dyes combined with enzymatic processes is an alternative to traditional methods.

https://dx.doi.org/10.21577/0103-5053.20230124

Published online: July 28, 2023

 

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J. Braz. Chem. Soc. 2024, 35(2), 1-10

Stochastic Sensing of Organotin Compounds with Alpha-Hemolysin Nanopore

Artur A. R. Silva ; Janilson J. Silva Júnior; Dijanah C. Machado; Frederico J. S. Pontes; Laércio Pol-Fachin; Juliana P. Aguiara; Claudio G. Rodrigues

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Stochastic biosensing is based on the observation of individual events reversible binding between molecules of organotin compounds (OTCs) and a single nanopore α-hemolysin (αHL). These current traces are recorded and stored, creating a unique digital signature that allows identification of the molecule under study.

https://dx.doi.org/10.21577/0103-5053.20230127

Published online: August 3, 2023

 

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Total access: 590


J. Braz. Chem. Soc. 2024, 35(2), 1-7

Kinetics and Activation Parameters for Dyeing of Cellulose-Polyethylene Terephthalate Blends with a Reactive Dye Using a Convenient, Robust Dye Flow‑System

Shirley Possidonio ; Camila S. M. Iar; Luzia P. Novaki; Omar A. El Seoud

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Representation of the dyeing process for cellulose-polyethylene terephthalate (PET) blends with a reactive dye in an aqueous medium.

https://dx.doi.org/10.21577/0103-5053.20230129

Published online: August 7, 2023

 

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Total access: 637


J. Braz. Chem. Soc. 2024, 35(2), 1-12

Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents

Victor Facchinetti; Claudia Regina B. Gomes; Karoline C. L. Aboud; Rodolfo G. Fiorot ; Guilherme G. C. de Carvalho;
Carlos Roberto K. Paier; Claudia do Ó Pessoa; Anne Caroline C. Gomes; Marcus Vinícius N. de Souza ; Thatyana R. A. Vasconcelos

How to cite this article

 

Quinoline-thiazole hybrids show high cytotoxicity against K562 cells and may interact with BCR-ABL1 kinase.

https://dx.doi.org/10.21577/0103-5053.20230139

Published online: August 17, 2023

 

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Total access: 982


Short Report J. Braz. Chem. Soc. 2024, 35(2), 1-7

Gold Nanoparticles Supported on Triazole-Functionalized Biochar as Nanocatalyst for Hydrogen Evolution from Aqueous Solution

Renata P. Lopes ; Qiuxia Zhao; Sergio Moya; Marta M. Moro; Didier Astruc

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Biochar modified with triazole groups was used as a support of gold nanocatalyst for hydrogen evolution, leading to excellent results.

https://dx.doi.org/10.21577/0103-5053.20230122

Published online: July 26, 2023

 

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Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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