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Medicinal Chemistry Collection 2017-2018

Papers from 2018

Synthesis and Antibacterial Evaluation of 3,5-Diaryl-1,2,4-oxadiazole Derivatives

Felipe S. Cunha; Joseli M. R. Nogueira; Alcino P. de Aguiar*

 

Synthesis and Antimicrobial Activity of Glycosylated 2-Aryl-5-amidinobenzimidazoles

Thiago B. de Souza; Josidel C. Oliver; Ana Paula B. Gomes; Cícero Flávio S. Aragão; Leandro S. Ferreira; Fernando Henrique A. Nogueira; Amanda Latércia T. Dias; Ricardo J. Alves*

 

Synergism in the Antibacterial Action of Ternary Mixtures Involving Silver Nanoparticles, Chitosan and Antibiotics

Marcelo S. L. Brasil; Aline L. Filgueiras; Marina B. Campos; Mariana S. L. Neves; Mateus Eugênio; Lídia A. Sena; Celso B. Sant'Anna; Vânia L. da Silva; Cláudio G. Diniz; Antonio C. Sant'Ana*

 

Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based β-Amino Alcohol Derivatives

Bhaskar R. Manda; Avvari N. Prasad; Narendar R. Thatikonda; Valdemar Lacerda Jr.; Layla R. Barbosa; Heloa Santos; Wanderson Romão; Fernando R. Pavan; Camila M. Ribeiro; Edson A. dos Santos; Maria R. Marques; Dênis P. de Lima; Ana C. Micheletti*; Adilson Beatriz*

 

Virtual Screening for the Selection of New Candidates to Trypanosoma cruzi Farnesyl Pyrophosphate Synthase Inhibitors

Larissa M. Oliveira; Janay S. C. Araújo; David B. Costa Júnior; Manoelito C. dos Santos Junior; Aníbal F. Santos Júnior*; Franco H. A. Leite

 

Potential Antileishmanial Activity of 4-N-Acylhydrazone Pyrazolo[3,4-d]pyridazin-7-ones: Synthesis, in vitro Biological Evaluations and Computational Studies

Andrey P. Jacomini; Michael J. V. da Silva; Julia Poletto; Gessica M. Ribeiro; Jessica T. C. Yokoyama; Danielle L. Bidóia; Fávero R. Paula; Celso V. Nakamura; Maria Helena Sarragiotto; Fernanda A. Rosa*

 

Design of Novel N-Myristoyltransferase Inhibitors of Leishmania donovani Using Four-Dimensional Quantitative Structure-Activity Relationship Analysis

Letícia Santos-Garcia; Daniela R. Silva; Letícia C. Assis; Tamiris M. de Assis; Giovanna C. Gajo; Ítalo Antônio Fernandes; Teodorico C. Ramalho; Elaine F. F. da Cunha*

 

Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Eugenol Esters as Leishmanicidal Agents

Camila M. Coelho*; Thiago dos Santos; Poliany G. Freitas; Juliana B. Nunes; Marcos J. Marques; Camila G. D. Padovani; Wagner A. S. Júdice; Ihosvany Camps; Nelson J. F. da Silveira; Diogo T. Carvalho; Marcia P. Veloso

 

1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents

Paulo Pitasse-Santos; Vitor Sueth-Santiago; Marco E. F. Lima*

 

An in silico Study of Benzophenone Derivatives as Potential Non-Competitive Inhibitors of Trypanosoma cruzi and Leishmania Amazonensis Cysteine Proteinases

Poliany G. Freitas*; Thiago E. Castilho; Leticia de Almeida; Claudia M. Maciel-Rezende; Luciano T. Costa; Claudio Viegas Junior; Marcos J. Marques; Marcelo H. dos Santos; Nelson J. F. da Silveira

 

Synthesis of 3,5-Diarylisoxazole Derivatives and Evaluation of in vitro Trypanocidal Activity

Aline A. N. de Souza; Viviane F. Xavier; Gleicekelly S. Coelho; Policarpo A. Sales Junior; Alvaro J. Romanha; Silvane M. F. Murta; Claudia M. Carneiro; Jason G. Taylor*

 

Synthesis of New Conjugates 1H‑Pyrazolo[3,4-b]pyridine-phosphoramidate and Evaluation against Leishmania amazonensis

Antonia C. R. F. Medeiros; Julio C. Borges; Klaus M. Becker; Raquel F. Rodrigues; Leonor L. Leon; Marilene Canto-Cavalheiro; Alice M. R. Bernardino; Marcos C. de Souza; Leandro F. Pedrosa*

 

Anti-Parasite and Cytotoxic Activities of Chloro and Bromo L-Tyrosine Derivatives

Manuel Pastrana Restrepo; Elkin Galeano Jaramillo*; Alejandro Martínez Martínez; Ana Mesa Arango; Sara Robledo Restrepo

 

Synthesis, Characterization and Evaluation of in vitro Antitumor Activities of Novel Chalcone-Quinolinone Hybrid Compounds

Giulio D. C. d'Oliveira; Andrea F. Moura; Manoel O. de Moraes; Caridad N. Perez; Luciano M. Lião*

 

Structure/Activity of PtII/N,N-Disubstituted-N'-acylthiourea Complexes: Anti‑Tumor and Anti-Mycobacterium tuberculosis Activities

Ana M. Plutín*; Anislay Alvarez; Raúl Mocelo; Raúl Ramos; Osmar C. Sánchez; Eduardo E. Castellano; Monize M. da Silva; Wilmer Villarreal; Legna Colina-Vegas; Fernando R. Pavan; Alzir A. Batista*

 

Synthesis and in vitro Antiproliferative Activity of Flavone and 6‑Hydroxyflavone Oxime Ethers Derivatives

John E. Díaz; Diana C. Martinez; Lina V. López; Gina M. Mendez; Ricardo Vera; Alix E. Loaiza*

 

Design, Synthesis and Anticancer Biological Evaluation of Novel 1,4-Diaryl-1,2,3‑triazole Retinoid Analogues of Tamibarotene (AM80)

Mariana A. A. Aleixo; Taís M. Garcia; Diego B. Carvalho; Luiz H. Viana; Marcos S. Amaral; Najla M. Kassab; Marilin C. Cunha; Indiara C. Pereira; Palimécio G. Guerrero Jr.; Renata T. Perdomo; Maria F. C. Matos; Adriano C. M. Baroni*

 

Identification of Anti-Inflammatory and Anti-Hypertensive Drugs as Inhibitors of Bacterial Diguanylate Cyclases

Helton J. Wiggers*; Edson Crusca; Éverton E. D. Silva; Juliana Cheleski; Naiara U. Torres; Marcos V. A. S. Navarro

 

Synthesis, Antioxidant Activity, Acetylcholinesterase Inhibition and Quantum Studies of Thiosemicarbazones

Larissa Sens; Aldo S. de Oliveira*; Alessandra Mascarello; Inês M. C. Brighente; Rosendo A. Yunes; Ricardo J. Nunes

 

Two Novel Donepezil-Lipoic Acid Hybrids: Synthesis, Anticholinesterase and Antioxidant Activities and Theoretical Studies

Bruna S. Terra; Pedro H. C. da Silva; Anna Tramarin; Lucas L. Franco; Elaine F. F. da Cunha; Fernando Macedo Junior; Teodorico C. Ramalho; Manuela Bartolini; Maria L. Bolognesi; Ângelo de Fátima*

 

Papers from 2017

Improvement of Solubility and Antifungal Activity of a New Aminothiophene Derivative by Complexation with 2-Hydroxypropyl-β-cyclodextrin

Giovanna R. A. Eleamen; Silvana C. da Costa; Reginaldo G. Lima-Neto; Rejane P. Neves; Larissa A. Rolim; Pedro J. Rolim-Neto; Ricardo O. Moura; Thiago M. de Aquino; Edson S. Bento; Marcus T. Scotti; Francisco J. B. Mendonça-Junior; Elisangela A. M. Mendonça; Elquio E. Oliveira*

 

Antitubercular Activity Increase in Labdane Diterpenes from Copaifera Oleoresin through Structural Modification

Aline N. Silva; Ana Carolina F. Soares; Mirela M. W. Cabral; Alex R. P. de Andrade; Marilza B. M. da Silva; Carlos H. G. Martins; Rodrigo C. S. Veneziani; Sérgio R. Ambrósio; Jairo K. Bastos; Vladimir C. G. Heleno*

 

Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

Sara L. S. Gomes; Gardenia C. G. Militão; Arinice M. Costa; Cláudia Ó. Pessoa; Letícia V. Costa-Lotufo; Edézio F. Cunha-Junior; Eduardo C. Torres-Santos; Paulo R. R. Costa; Alcides J. M. da Silva*

 

Silver Nanocoatings at Large Length Scales: Influence of the AgNPs Morphology and Capping Agents on the Coating Chemical Stability and Antimicrobial Effect

Francisco A. Sousa; Victor T. Noronha; Terezinha F. Machado; José V. Silveira; Francisco A. Cunha; Pierre B. A. Fechine; Amauri J. Paula*

 

Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II) isonicotinoylhydrazones

Thais P. Gazzi; Mariane Rotta; Anne D. Villela; Valnês Rodrigues-Junior; Leonardo K. B. Martinelli; Francisco Adilson M. Sales; Eduardo Henrique Silva de Sousa; Maria Martha Campos; Luiz Augusto Basso; Diógenes S. Santos*; Pablo Machado*

 

Anti-Trypanosoma Activity and Synergistic Effects of Natural and Semi-Synthetic Triterpenes and Predominant Cell Death through Autophagy in Amastigote Forms

Gleison D. P. Bossolani; Tânia Ueda-Nakamura; Sueli O. Silva; Benedito P. Dias Filho; Tulio O. G. Costa; Raúl H. R. Quintanilla; Sabrina T. Martinez; Valdir F. Veiga-Junior; Angelo C. Pinto; Celso V. Nakamura*

 

 

Online version ISSN 1678-4790 Printed version ISSN 0103-5053
Journal of the Brazilian Chemical Society
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